Serum FGF21 levels are associated with brown adipose tissue activity in humans

The obesity pandemic has spurred a need for novel therapies to prevent and treat metabolic complications. The recent rediscovery of brown adipose tissue (BAT) in humans made this tissue a possible therapeutic target, due to its potentially substantial contributions to energy homeostasis. Fibroblast...

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Published inScientific reports Vol. 5; no. 1; p. 10275
Main Authors Hanssen, Mark J.W., Broeders, Evie, Samms, Ricardo J., Vosselman, Maarten J., van der Lans, Anouk A.J.J., Cheng, Christine C., Adams, Andrew C., van Marken Lichtenbelt, Wouter D., Schrauwen, Patrick
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 18.05.2015
Nature Publishing Group
Subjects
59/78
631/443/319/1642/2037
631/443/319/2723
692/163/2743/2037
Acclimation
Acclimatization
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - physiology
Adult
Animal behavior
Cold
Cold acclimation
Computed tomography
Diabetes mellitus
Dyslipidemia
Energy balance
Energy Metabolism
Female
Fibroblast growth factors
Fibroblast Growth Factors - blood
Homeostasis
Humanities and Social Sciences
Humans
Male
Metabolism
multidisciplinary
Obesity
Pandemics
Positron-Emission Tomography
Science
Temperature effects
Thermogenesis
Tomography, X-Ray Computed
Young Adult
Online AccessGet full text

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Abstract The obesity pandemic has spurred a need for novel therapies to prevent and treat metabolic complications. The recent rediscovery of brown adipose tissue (BAT) in humans made this tissue a possible therapeutic target, due to its potentially substantial contributions to energy homeostasis. Fibroblast growth factor 21 (FGF21) has been identified as a facilitator of cold-induced thermogenesis in humans. Furthermore, pre-clinical studies revealed that FGF21 administration leads to improvement in the metabolic consequences of obesity, such as dyslipidemia and type 2 diabetes. Here we studied plasma FGF21 levels in two cohorts of human subjects, in whom BAT activity was determined using an individualized cooling protocol by [ 18 F]FDG-PET/CT scan. Importantly, we found that circulating FGF21 levels correlated with BAT activity during acute cold exposure in male subjects. In addition, FGF21 levels were related to the change in core temperature upon acute cold exposure, indicating a role for FGF21 in maintaining normothermia, possibly via activation of BAT. Furthermore, cold acclimation increased BAT activity in parallel with increased FGF21 levels. In conclusion, our results demonstrate that FGF21 levels in humans are related to BAT activity, suggesting that FGF21 may represent a novel mechanism via which BAT activity in humans may be enhanced.
AbstractList The obesity pandemic has spurred a need for novel therapies to prevent and treat metabolic complications. The recent rediscovery of brown adipose tissue (BAT) in humans made this tissue a possible therapeutic target, due to its potentially substantial contributions to energy homeostasis. Fibroblast growth factor 21 (FGF21) has been identified as a facilitator of cold-induced thermogenesis in humans. Furthermore, pre-clinical studies revealed that FGF21 administration leads to improvement in the metabolic consequences of obesity, such as dyslipidemia and type 2 diabetes. Here we studied plasma FGF21 levels in two cohorts of human subjects, in whom BAT activity was determined using an individualized cooling protocol by [18 F]FDG-PET/CT scan. Importantly, we found that circulating FGF21 levels correlated with BAT activity during acute cold exposure in male subjects. In addition, FGF21 levels were related to the change in core temperature upon acute cold exposure, indicating a role for FGF21 in maintaining normothermia, possibly via activation of BAT. Furthermore, cold acclimation increased BAT activity in parallel with increased FGF21 levels. In conclusion, our results demonstrate that FGF21 levels in humans are related to BAT activity, suggesting that FGF21 may represent a novel mechanism via which BAT activity in humans may be enhanced.
The obesity pandemic has spurred a need for novel therapies to prevent and treat metabolic complications. The recent rediscovery of brown adipose tissue (BAT) in humans made this tissue a possible therapeutic target, due to its potentially substantial contributions to energy homeostasis. Fibroblast growth factor 21 (FGF21) has been identified as a facilitator of cold-induced thermogenesis in humans. Furthermore, pre-clinical studies revealed that FGF21 administration leads to improvement in the metabolic consequences of obesity, such as dyslipidemia and type 2 diabetes. Here we studied plasma FGF21 levels in two cohorts of human subjects, in whom BAT activity was determined using an individualized cooling protocol by [ 18 F]FDG-PET/CT scan. Importantly, we found that circulating FGF21 levels correlated with BAT activity during acute cold exposure in male subjects. In addition, FGF21 levels were related to the change in core temperature upon acute cold exposure, indicating a role for FGF21 in maintaining normothermia, possibly via activation of BAT. Furthermore, cold acclimation increased BAT activity in parallel with increased FGF21 levels. In conclusion, our results demonstrate that FGF21 levels in humans are related to BAT activity, suggesting that FGF21 may represent a novel mechanism via which BAT activity in humans may be enhanced.
ArticleNumber 10275
Author Cheng, Christine C.
van Marken Lichtenbelt, Wouter D.
Samms, Ricardo J.
van der Lans, Anouk A.J.J.
Schrauwen, Patrick
Vosselman, Maarten J.
Hanssen, Mark J.W.
Broeders, Evie
Adams, Andrew C.
Author_xml – sequence: 1
  givenname: Mark J.W.
  surname: Hanssen
  fullname: Hanssen, Mark J.W.
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  givenname: Evie
  surname: Broeders
  fullname: Broeders, Evie
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  givenname: Ricardo J.
  surname: Samms
  fullname: Samms, Ricardo J.
  organization: Lilly Research Laboratories, Lilly Corporate Center
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  givenname: Maarten J.
  surname: Vosselman
  fullname: Vosselman, Maarten J.
  organization: Department of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism,Maastricht University Medical Centre+(MUMC+)
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  givenname: Anouk A.J.J.
  surname: van der Lans
  fullname: van der Lans, Anouk A.J.J.
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– sequence: 6
  givenname: Christine C.
  surname: Cheng
  fullname: Cheng, Christine C.
  organization: Lilly Research Laboratories, Lilly Corporate Center
– sequence: 7
  givenname: Andrew C.
  surname: Adams
  fullname: Adams, Andrew C.
  organization: Lilly Research Laboratories, Lilly Corporate Center
– sequence: 8
  givenname: Wouter D.
  surname: van Marken Lichtenbelt
  fullname: van Marken Lichtenbelt, Wouter D.
  organization: Department of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism,Maastricht University Medical Centre+(MUMC+)
– sequence: 9
  givenname: Patrick
  surname: Schrauwen
  fullname: Schrauwen, Patrick
  organization: Department of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism,Maastricht University Medical Centre+(MUMC+)
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ContentType Journal Article
Copyright The Author(s) 2015
Copyright Nature Publishing Group May 2015
Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited
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Snippet The obesity pandemic has spurred a need for novel therapies to prevent and treat metabolic complications. The recent rediscovery of brown adipose tissue (BAT)...
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SubjectTerms 59/78
631/443/319/1642/2037
631/443/319/2723
692/163/2743/2037
Acclimation
Acclimatization
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - physiology
Adult
Animal behavior
Cold
Cold acclimation
Computed tomography
Diabetes mellitus
Dyslipidemia
Energy balance
Energy Metabolism
Female
Fibroblast growth factors
Fibroblast Growth Factors - blood
Homeostasis
Humanities and Social Sciences
Humans
Male
Metabolism
multidisciplinary
Obesity
Pandemics
Positron-Emission Tomography
Science
Temperature effects
Thermogenesis
Tomography, X-Ray Computed
Young Adult
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Title Serum FGF21 levels are associated with brown adipose tissue activity in humans
URI https://link.springer.com/article/10.1038/srep10275
https://www.ncbi.nlm.nih.gov/pubmed/25985218
https://www.proquest.com/docview/1899505310
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https://pubmed.ncbi.nlm.nih.gov/PMC4434994
Volume 5
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