Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology

• Published in: Cancer research (Chicago, Ill.) Vol. 69; no. 23; pp. 9065 - 9072
• Main Authors: Gravendeel, Lonneke A.M., Kouwenhoven, Mathilde C.M., Gevaert, Olivier, de Rooi, Johan J., Stubbs, Andrew P., Duijm, J. Elza, Daemen, Anneleen, Bleeker, Fonnet E., Bralten, Linda B.C., Kloosterhof, Nanne K., De Moor, Bart, Eilers, Paul H.C., van der Spek, Peter J., Kros, Johan M., Sillevis Smitt, Peter A.E., van den Bent, Martin J., French, Pim J.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.12.2009
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Child; Cluster Analysis; Female; Gene Expression Profiling; Glioma - genetics; Glioma - pathology; Humans; Male; Medical sciences; Middle Aged; Neurology; Pharmacology. Drug treatments; Prognosis; Reproducibility of Results; Survival Rate; Tumors; Tumors of the nervous system. Phacomatoses; Young Adult; Nervous system diseases; Glioma; Central nervous system disease; Tumor; Histology; Predictive factor; Survival; Gene expression profile

Gliomas are the most common primary brain tumors with heterogeneous morphology and variable prognosis. Treatment decisions in patients rely mainly on histologic classification and clinical parameters. However, differences between histologic subclasses and grades are subtle, and classifying gliomas i...