Multilayered regulations of RIG-I in the anti-viral signaling pathway

• Published in: The Journal of Microbiology Vol. 54; no. 9; pp. 583 - 587
• Main Authors: Kim, Nari, Now, Hesung, Nguyen, Nhung T. H., Yoo, Joo-Yeon
• Format: Journal Article Book Review
• Language: English
• Published: Seoul The Microbiological Society of Korea 01.09.2016; Springer Nature B.V; 한국미생물학회
• Subjects: Animals; Biomedical and Life Sciences; DEAD Box Protein 58 - genetics; DEAD Box Protein 58 - immunology; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Life Sciences; Microbiology; Minireview; Protein Binding; Receptors, Immunologic; Signal Transduction; Virus Diseases - genetics; Virus Diseases - immunology; Virus Diseases - virology; Viruses - genetics; Viruses - immunology; 생물학; RIG-I; protein-protein interaction; antiviral signaling; post-translational modification; RNA virus
• ISSN: 1225-8873; 1976-3794
• DOI: 10.1007/s12275-016-6322-2

RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an antiviral signaling that induces the production of interferons and proinflammatory cytokines. Because inappropriate RIG-I signaling affects either viral clearance or immune toxicity, multiple regulations of RIG-I have been investigated since its discovery as the viral RNA detector. In this review, we describe the recent progress in research on the regulation of RIG-I activity or abundance. Specifically, we focus on the mechanism that modulates RIG-I-dependent antiviral response through post-translational modifications of or protein-protein interactions with RIG-I.