The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis

Purpose The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. Methods The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed...

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Published inEuropean journal of nutrition Vol. 55; no. 6; pp. 2163 - 2176
Main Authors Jamka, Małgorzata, Woźniewicz, Małgorzata, Walkowiak, Jarosław, Bogdański, Paweł, Jeszka, Jan, Stelmach-Mardas, Marta
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2016
Springer Nature B.V
Subjects
25-hydroxycholecalciferol
Adolescent
Adult
Aged
biomarkers
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Chemistry
Chemistry and Materials Science
Databases, Factual
Dietary Supplements
Humans
interleukin-6
Interleukin-6 - blood
meta-analysis
Middle Aged
Nutrition
Obesity - blood
Original Contribution
overweight
Overweight - blood
randomized clinical trials
Randomized Controlled Trials as Topic
systematic review
tumor necrosis factor-alpha
Tumor Necrosis Factor-alpha - blood
Vitamin D - administration & dosage
Vitamin D - blood
vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - diagnosis
vitamin supplements
Young Adult
Obesity
C-reactive protein
Vitamin D
Cytokines
Adipokines
Dietary supplements
Online AccessGet full text
ISSN1436-6207
1436-6215
1436-6215
DOI10.1007/s00394-015-1089-5

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Abstract Purpose The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. Methods The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle–Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed. Results The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences −0.11; 95 % CI −0.27–0.04; p  = 0.15), TNF-α (std. mean differences −0.13; 95 % CI −0.38–0.12; p  = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI −0.43–0.63; p  = 0.71). Conclusions This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.
AbstractList The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle-Ottawa scale was used, and a high-quality study was defined by a threshold of greater than or equal to 7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF- alpha ) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed. The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences -0.11; 95 % CI -0.27-0.04; p = 0.15), TNF- alpha (std. mean differences -0.13; 95 % CI -0.38-0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI -0.43-0.63; p = 0.71). This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.
Purpose The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. Methods The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle–Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed. Results The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences −0.11; 95 % CI −0.27–0.04; p  = 0.15), TNF-α (std. mean differences −0.13; 95 % CI −0.38–0.12; p  = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI −0.43–0.63; p  = 0.71). Conclusions This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.
Purpose The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. Methods The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle-Ottawa scale was used, and a high-quality study was defined by a threshold of [greater than or equal to]7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-[alpha]) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed. Results The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences -0.11; 95 % CI -0.27-0.04; p = 0.15), TNF-[alpha] (std. mean differences -0.13; 95 % CI -0.38-0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI -0.43-0.63; p = 0.71). Conclusions This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.
The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle-Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed. The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences -0.11; 95 % CI -0.27-0.04; p = 0.15), TNF-α (std. mean differences -0.13; 95 % CI -0.38-0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI -0.43-0.63; p = 0.71). This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.
PURPOSE: The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects. METHODS: The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle–Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed. RESULTS: The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences −0.11; 95 % CI −0.27–0.04; p = 0.15), TNF-α (std. mean differences −0.13; 95 % CI −0.38–0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI −0.43–0.63; p = 0.71). CONCLUSIONS: This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.
The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects.PURPOSEThe objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects.The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle-Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed.METHODSThe search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle-Ottawa scale was used, and a high-quality study was defined by a threshold of ≥7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed.The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences -0.11; 95 % CI -0.27-0.04; p = 0.15), TNF-α (std. mean differences -0.13; 95 % CI -0.38-0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI -0.43-0.63; p = 0.71).RESULTSThe baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences -0.11; 95 % CI -0.27-0.04; p = 0.15), TNF-α (std. mean differences -0.13; 95 % CI -0.38-0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI -0.43-0.63; p = 0.71).This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.CONCLUSIONSThis meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.
Author Woźniewicz, Małgorzata
Walkowiak, Jarosław
Bogdański, Paweł
Jeszka, Jan
Stelmach-Mardas, Marta
Jamka, Małgorzata
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  fullname: Walkowiak, Jarosław
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  fullname: Bogdański, Paweł
  organization: Department of Education and Obesity Treatment and Metabolic Disorders, Poznan University of Medical Sciences
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  email: stelmach@dife.de
  organization: Department of Paediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26538075$$D View this record in MEDLINE/PubMed
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Issue 6
Keywords Obesity
C-reactive protein
Vitamin D
Cytokines
Adipokines
Dietary supplements
Language English
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PublicationTitle European journal of nutrition
PublicationTitleAbbrev Eur J Nutr
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PublicationYear 2016
Publisher Springer Berlin Heidelberg
Springer Nature B.V
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References_xml – reference: HozoSPDjulbegovicBHozoIEstimating the mean and variance from the median, range, and the size of a sampleBMC Med Res Methodol200551310.1186/1471-2288-5-13
– reference: BallouSPLozanskiFBHodderSQuantitative and qualitative alterations of acute-phase proteins in healthy elderly personsAge Ageing1996252242301:STN:280:DyaK28zisVahtA%3D%3D10.1093/ageing/25.3.224
– reference: HarrisSSPittasAGPalermoNJA randomized, control-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African AmericansDiabetes Obes Metab20121497897941:CAS:528:DC%2BC38XhtFOmsLbK10.1111/j.1463-1326.2012.01605.x
– reference: Jamka M, Woźniewicz M, Bogdański P, Stelmach-Mardas M (2015) Effect of vitamin D supplementation on inflammatory cytokines, adipokines and C-reactive protein in obese subjects. PROSPERO: CRD4201501641. http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015016416. Accessed 4 Feb 2015
– reference: ZittermannAFrischSBertholdHKGöttingCKuhnJKleesiekKVitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markersAm J Clin Nutr2009895132113271:CAS:528:DC%2BD1MXlt1Ortr8%3D10.3945/ajcn.2008.27004
– reference: von HurstPRStonehouseWCoadJVitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient: a randomised, placebo-controlled trialBr J Nutr2010103454955510.1017/S0007114509992017
– reference: ParkHSParkJYYuRRelationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6Diabetes Res Clin Pract200569129351:CAS:528:DC%2BD2MXlt1Giu7c%3D10.1016/j.diabres.2004.11.007
– reference: Stelmach-MardasMMardasMWalkowiakJBoeingHLong-term weight status in regainers after weight loss by lifestyle intervention: status and challengesProc Nutr Soc2014739450951810.1017/S0029665114000718
– reference: International Diabetes Federation (2006) The IDF consensus worldwide definition of the metabolic syndrome. http://www.idf.org/webdata/docs/IDF_Meta_def_final.pdf. Accessed 9 Mar 2015
– reference: Pereira-SantosMCostaPRAssisAMSantosCASantosDBObesity and vitamin D deficiency: a systematic review and meta-analysisObes Rev20151643413491:CAS:528:DC%2BC2MXksF2jt7w%3D10.1111/obr.12239
– reference: BelliaAGarcovichCD’AdamoMLombardoMTesauroMDonadelGSerum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjectsIntern Emerg Med201381334010.1007/s11739-011-0559-x
– reference: ShahSWilsonDMBachrachLKLarge doses of vitamin D fail to increase 25-hydroxyvitamin D levels or to alter cardiovascular risk factors in obese adolescents: a pilot studyJ Adolesc Health2015571192310.1016/j.jadohealth.2015.02.006
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SecondaryResourceType review_article
Snippet Purpose The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and...
The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight...
Purpose The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and...
PURPOSE: The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and...
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springer
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SubjectTerms 25-hydroxycholecalciferol
Adolescent
Adult
Aged
biomarkers
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Chemistry
Chemistry and Materials Science
Databases, Factual
Dietary Supplements
Humans
interleukin-6
Interleukin-6 - blood
meta-analysis
Middle Aged
Nutrition
Obesity - blood
Original Contribution
overweight
Overweight - blood
randomized clinical trials
Randomized Controlled Trials as Topic
systematic review
tumor necrosis factor-alpha
Tumor Necrosis Factor-alpha - blood
Vitamin D - administration & dosage
Vitamin D - blood
vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - diagnosis
vitamin supplements
Young Adult
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Title The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis
URI https://link.springer.com/article/10.1007/s00394-015-1089-5
https://www.ncbi.nlm.nih.gov/pubmed/26538075
https://www.proquest.com/docview/1815923833
https://www.proquest.com/docview/1816634183
https://www.proquest.com/docview/1827910289
https://www.proquest.com/docview/2000293154
Volume 55
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