A Defective Interfering Influenza RNA Inhibits Infectious Influenza Virus Replication in Human Respiratory Tract Cells: A Potential New Human Antiviral

• Published in: Viruses Vol. 8; no. 8; p. 237
• Main Authors: Smith, Claire, Scott, Paul, O’Callaghan, Christopher, Easton, Andrew, Dimmock, Nigel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 22.08.2016; MDPI AG
• Subjects: Administration, Intranasal; Animals; antiviral; Antiviral Agents - administration & dosage; Antiviral Agents - metabolism; defective interfering; Defective Viruses - genetics; Disease Models, Animal; Epithelial Cells - virology; Ferrets; Fibroblasts - virology; human respiratory cells; Humans; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - physiology; influenza virus; Mice; Orthomyxoviridae Infections - prevention & control; RNA, Viral - administration & dosage; RNA, Viral - metabolism; Virus Replication - drug effects; defective interfering; influenza virus; human respiratory cells; antiviral

Defective interfering (DI) viruses arise during the replication of influenza A virus and contain a non-infective version of the genome that is able to interfere with the production of infectious virus. In this study we hypothesise that a cloned DI influenza A virus RNA may prevent infection of human...