Myosin light chain kinase controls voltage-dependent calcium channels in vascular smooth muscle

• Published in: Pflügers Archiv Vol. 466; no. 7; pp. 1377 - 1389
• Main Authors: Martinsen, A., Schakman, O., Yerna, X., Dessy, C., Morel, N.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2014; Springer Nature B.V
• Subjects: Animals; Arginine Vasopressin - pharmacology; Biomedical and Life Sciences; Biomedicine; Calcium - metabolism; Calcium Channels, L-Type - genetics; Calcium Channels, L-Type - metabolism; Calcium Channels, T-Type - genetics; Calcium Channels, T-Type - metabolism; Cell Biology; Cell Line; Human Physiology; Ion Channels; Male; Molecular Medicine; Muscle Contraction; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - physiology; Myosin-Light-Chain Kinase - genetics; Myosin-Light-Chain Kinase - metabolism; Neurosciences; Norepinephrine - pharmacology; Potassium Chloride - pharmacology; Rats; Rats, Wistar; Receptors; Receptors and Transporters; RNA, Messenger - genetics; RNA, Messenger - metabolism; Vasoconstriction; Voltage-dependent calcium channels; Resistance mesenteric artery; Myosin light chain kinase; A7r5

The Ca 2+ -dependent kinase myosin light chain kinase (MLCK) is the activator of smooth muscle contraction. In addition, it has been reported to be involved in Ca 2+ channel regulation in cultured cells, and we previously showed that the MLCK inhibitor ML-7 decreases arginine vasopressin (AVP)-induc...