An efficient algorithm to identify the optimal one-bit perturbation based on the basin-of-state size of Boolean networks

• Published in: Scientific reports Vol. 6; no. 1; p. 26247
• Main Authors: Hu, Mingxiao, Shen, Liangzhong, Zan, Xiangzhen, Shang, Xuequn, Liu, Wenbin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.05.2016; Nature Publishing Group
• Subjects: 631/114/2114; 631/114/2397; Algorithms; Humanities and Social Sciences; multidisciplinary; Science

Boolean networks are widely used to model gene regulatory networks and to design therapeutic intervention strategies to affect the long-term behavior of systems. In this paper, we investigate the less-studied one-bit perturbation, which falls under the category of structural intervention. Previous w...