Effects of allergic diseases and age on the composition of serum IgG glycome in children

• Published in: Scientific reports Vol. 6; no. 1; p. 33198
• Main Authors: Pezer, Marija, Stambuk, Jerko, Perica, Marija, Razdorov, Genadij, Banic, Ivana, Vuckovic, Frano, Gospic, Adrijana Miletic, Ugrina, Ivo, Vecenaj, Ana, Bakovic, Maja Pucic, Lokas, Sandra Bulat, Zivkovic, Jelena, Plavec, Davor, Devereux, Graham, Turkalj, Mirjana, Lauc, Gordan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.09.2016; Nature Publishing Group
• Subjects: 631/1647/296; 631/250/2152/2153/1291; 631/337/458/1524; 631/45/221; 692/308/3187; 82/47; 82/58; Affinity chromatography; Age Factors; Allergens; Allergic diseases; Allergies; Carbohydrate Sequence; Case-Control Studies; Child; Child, Preschool; Children; Chromatography; Female; Glycomics; Glycopeptides; Glycosylation; Humanities and Social Sciences; Humans; Hypersensitivity; Hypersensitivity - blood; Hypersensitivity - immunology; Immunoglobulin E; Immunoglobulin G; Immunoglobulin G - blood; Ionization; Ions; Liquid chromatography; Male; Mass spectrometry; Mass spectroscopy; multidisciplinary; Polysaccharides; Protein G; Protein Processing, Post-Translational; Science

It is speculated that immunoglobulin G (IgG) plays a regulatory role in allergic reactions. The glycans on the Fc region are known to affect IgG effector functions, thereby possibly having a role in IgG modulation of allergic response. This is the first study investigating patients’ IgG glycosylatio...