Construction of integrated gene logic-chip

• Published in: Nature nanotechnology Vol. 13; no. 10; pp. 933 - 940
• Main Authors: Masubuchi, Takeya, Endo, Masayuki, Iizuka, Ryo, Iguchi, Ayaka, Yoon, Dong Hyun, Sekiguchi, Tetsushi, Qi, Hao, Iinuma, Ryosuke, Miyazono, Yuya, Shoji, Shuichi, Funatsu, Takashi, Sugiyama, Hiroshi, Harada, Yoshie, Ueda, Takuya, Tadakuma, Hisashi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2018; Nature Publishing Group
• Subjects: 639/766/747; 639/925/926/1048; Automation; Chemistry and Materials Science; Circuit design; Circuits; Crosstalk; Deoxyribonucleic acid; DNA; DNA-directed RNA polymerase; Enzymes; Gene expression; Genes; Information processing; Letter; Logic circuits; Materials Science; miRNA; Nanotechnology; Nanotechnology and Microengineering; Ribonucleic acid; RNA; RNA polymerase; Signal processing; Substrates

In synthetic biology, the control of gene expression requires a multistep processing of biological signals. The key steps are sensing the environment, computing information and outputting products 1 . To achieve such functions, the laborious, combinational networking of enzymes and substrate-genes i...