Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

• Published in: Journal of Alzheimer's disease Vol. 55; no. 3; pp. 1083 - 1099
• Main Authors: Nilson, Ashley N., English, Kelsey C., Gerson, Julia E., Barton Whittle, T., Nicolas Crain, C., Xue, Judy, Sengupta, Urmi, Castillo-Carranza, Diana L., Zhang, Wenbo, Gupta, Praveena, Kayed, Rakez
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2017
• Subjects: Age Factors; Animals; Astrocytes - metabolism; Astrocytes - pathology; Calcium-Binding Proteins - metabolism; Cytokines - metabolism; Disease Models, Animal; Encephalitis - etiology; Encephalitis - metabolism; Gene Expression Regulation - genetics; Glial Fibrillary Acidic Protein - metabolism; HMGB1 Protein - metabolism; Mice; Mice, Transgenic; Microfilament Proteins - metabolism; Mutation - genetics; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - genetics; Neurons - metabolism; Neurons - pathology; Retinitis - etiology; Retinitis - metabolism; Retinitis - pathology; tau Proteins - genetics; tau Proteins - metabolism; retinal degeneration; tauopathy; Alzheimer’s disease; neuroinflammation; oligomer; tau protein; frontotemporal lobar dementia

It is well-established that inflammation plays an important role in Alzheimer’s disease (AD) and frontotemporal lobar dementia (FTLD). Inflammation and synapse loss occur in disease prior to the formation of larger aggregates, but the contribution of tau to inflammation has not yet been thoroughly i...