In situ remineralization of white-spot enamel lesions by 500 and 1,100 ppm F dentifrices

• Published in: Clinical oral investigations Vol. 16; no. 4; pp. 1007 - 1014
• Main Authors: Mensinkai, Poornima K., Ccahuana-Vasquez, Renzo A., Chedjieu, Irene, Amaechi, Bennett T., Mackey, Allen C., Walker, Trenton J., Blanken, Douglas D., Karlinsey, Robert L.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2012; Springer Nature B.V
• Subjects: Adolescent; Adult; Biocompatible Materials - administration & dosage; Biocompatible Materials - therapeutic use; Calcium Phosphates - administration & dosage; Calcium Phosphates - therapeutic use; Cariostatic Agents - administration & dosage; Cariostatic Agents - therapeutic use; Cross-Over Studies; Dental Caries - pathology; Dental Caries - therapy; Dental Enamel - drug effects; Dental Enamel - pathology; Dentifrices - therapeutic use; Dentistry; Female; Hardness; Humans; Male; Medicine; Microradiography; Middle Aged; Minerals - analysis; Original Article; Silicic Acid - administration & dosage; Silicic Acid - therapeutic use; Sodium Fluoride - administration & dosage; Sodium Fluoride - therapeutic use; Tooth Remineralization - methods; Toothbrushing - methods; Toothpastes - administration & dosage; Toothpastes - therapeutic use; Young Adult; Dentifrice; Caries; Fluoride; fTCP; Remineralization
• ISSN: 1432-6981; 1436-3771; 1436-3771
• DOI: 10.1007/s00784-011-0591-2

The aim of this study was to evaluate the remineralization potential of three silica-containing NaF dentifrice systems in an intraoral model. Subjects ( N  = 30) in this randomized, three-phase, 28-day, crossover study served as their own control. Each participant wore a customized orthodontic appliance attached to a mandibular molar and contained one tooth block with caries-like lesion. For each phase, participants engaged in twice-daily brushing for 2 min with one of the following dentifrices: 500 ppm F, 500 ppm F plus functionalized β-tricalcium phosphate (fTCP), and a clinically proven 1,100 ppm F. After each phase, appliances were removed, and specimens were analyzed using surface microhardness (SMH), transverse microradiography (TMR), and cross-sectional microhardness (CSMH). Statistically significant ( p  < 0.05) remineralization of white-spot lesions relative to baseline occurred for each dentifrice as determined with SMH and TMR. No significant differences ( p  > 0.05) in SMH were found among the three groups, but trending revealed the 500 ppm F plus fTCP produced 26% and 27% greater SMH recovery relative to 500 and 1,100 ppm F, respectively. Similarly, no significant differences ( p  > 0.05) in TMR were found among the groups. However, the 500 ppm F plus fTCP dentifrice produced 10% and 38% greater mineral recovery relative to 500 and 1,100 ppm F, respectively, while reducing the lesion depth 30% and 52%, respectively. Significant differences ( p  < 0.05) in CSMH existed among the three dentifice groups at different enamel depths, but statistical differences ( p  < 0.05) in relative lesion size were only found between 500 ppm F plus fTCP and 500 ppm F. The combination of fTCP and fluoride in a single-compartment, water-based dentifrice can cooperate with fluoride to produce significant remineralization. These results suggest that the combination of 500 ppm F with fTCP may provide comparable anticaries benefits relative to a 1,100 ppm F dentifrice.