Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport

• Published in: Scientific reports Vol. 6; no. 1; p. 32105
• Main Authors: Fernández-Suárez, María E., Escolà-Gil, Joan C., Pastor, Oscar, Dávalos, Alberto, Blanco-Vaca, Francisco, Lasunción, Miguel A., Martínez-Botas, Javier, Gómez-Coronado, Diego
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.09.2016; Nature Publishing Group
• Subjects: 13; 14; 14/19; 14/34; 14/63; 17β-Estradiol; 38; 38/77; 631/45/287/1191; 64; 64/60; 692/163; 82; 82/1; 82/16; 82/29; 82/80; ABCA1 protein; Acetyl-CoA C-Acetyltransferase - antagonists & inhibitors; Animals; Antiestrogens; Apolipoprotein A; Apolipoprotein A-I; Apolipoprotein A-I - metabolism; ATP Binding Cassette Transporter 1 - biosynthesis; ATP Binding Cassette Transporter 1 - genetics; ATP Binding Cassette Transporter, Sub-Family G - biosynthesis; ATP Binding Cassette Transporter, Sub-Family G - genetics; ATP-binding protein; Biological Transport - drug effects; Cholesterol; Cholesterol - analysis; Cholesterol - blood; Cholesterol - metabolism; Cholesterol Esters - metabolism; Diet, Western; Esterification - drug effects; Estradiol - analogs & derivatives; Estradiol - pharmacology; Estrogen receptors; Estrogens; Feces - chemistry; High density lipoprotein; Homeostasis; Humanities and Social Sciences; Humans; Lipoproteins, HDL - metabolism; Lipoproteins, LDL - metabolism; Liver; Liver - chemistry; Liver - drug effects; Low density lipoprotein; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; multidisciplinary; Protein transport; Raloxifene; Raloxifene Hydrochloride - pharmacology; Science; Science (multidisciplinary); Selective estrogen receptor modulators; Selective Estrogen Receptor Modulators - pharmacology; Tamoxifen; Tamoxifen - pharmacology; THP-1 Cells; Toremifene; Toremifene - pharmacology

Selective estrogen receptor modulators (SERMs) are widely prescribed drugs that alter cellular and whole-body cholesterol homeostasis. Here we evaluate the effect of SERMs on the macrophage-specific reverse cholesterol transport (M-RCT) pathway, which is mediated by HDL. Treatment of human and mouse...