Intramuscular gentamicin improves the efficacy of ciprofloxacin as an antibiotic prophylaxis for transrectal prostate biopsy
Infection-related complications after transrectal ultrasound guided prostatic biopsy (TRPB) could be life threatening. Our centre observed sepsis after TRPB despite prophylactic oral ciprofloxacin. We reviewed all cases of post-TRPB sepsis with their bacteriology and evaluated if the addition of int...
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Published in | Annals of the Academy of Medicine, Singapore Vol. 38; no. 3; pp. 212 - 216 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Singapore
01.03.2009
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Abstract | Infection-related complications after transrectal ultrasound guided prostatic biopsy (TRPB) could be life threatening. Our centre observed sepsis after TRPB despite prophylactic oral ciprofloxacin. We reviewed all cases of post-TRPB sepsis with their bacteriology and evaluated if the addition of intramuscular (I/M) gentamicin to standard prophylaxis before TRPB could reduce its incidence.
In a single urological centre, we performed an interventional study that compared a prospective group with retrospective control. The latter is known as the "cipro-only" group included consecutive patients who underwent TRPB between 1 September 2003 and 31 August 2004. The addition of I/M gentamicin 80 mg half an hour before TRPB started on 1 September 2004. All subsequent patients who underwent TRPB until 31 August 2005 were included in the "cipro+genta" group. Patients who did not receive the studied antibiotics were excluded.
There were 374 patients in the "cipro+genta" group and 367 patients in the "cipro-only" group with comparable profiles. There were 12 cases of post-TRPB sepsis in the "cipro-only" group and 5 cases in the "cipro+genta" group. Ciprofloxacin-resistant Escherichia coli (E. coli) was the only pathogen isolated in both groups. In the "cipro-only" group, 9 patients had positive blood cultures and 8 were sensitive to gentamicin. In the "cipro+genta" group, the only positive E. coli was gentamicin-resistant. One patient in the "cipro+genta" group was admitted to the intensive care unit with septicaemia.
The addition of I/M gentamicin to oral ciprofloxacin is a safe and effective prophylactic antibiotic regime in reducing the incidence of post-TRPB sepsis. |
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AbstractList | INTRODUCTIONInfection-related complications after transrectal ultrasound guided prostatic biopsy (TRPB) could be life threatening. Our centre observed sepsis after TRPB despite prophylactic oral ciprofloxacin. We reviewed all cases of post-TRPB sepsis with their bacteriology and evaluated if the addition of intramuscular (I/M) gentamicin to standard prophylaxis before TRPB could reduce its incidence. MATERIALS AND METHODSIn a single urological centre, we performed an interventional study that compared a prospective group with retrospective control. The latter is known as the "cipro-only" group included consecutive patients who underwent TRPB between 1 September 2003 and 31 August 2004. The addition of I/M gentamicin 80 mg half an hour before TRPB started on 1 September 2004. All subsequent patients who underwent TRPB until 31 August 2005 were included in the "cipro+genta" group. Patients who did not receive the studied antibiotics were excluded. RESULTSThere were 374 patients in the "cipro+genta" group and 367 patients in the "cipro-only" group with comparable profiles. There were 12 cases of post-TRPB sepsis in the "cipro-only" group and 5 cases in the "cipro+genta" group. Ciprofloxacin-resistant Escherichia coli (E. coli) was the only pathogen isolated in both groups. In the "cipro-only" group, 9 patients had positive blood cultures and 8 were sensitive to gentamicin. In the "cipro+genta" group, the only positive E. coli was gentamicin-resistant. One patient in the "cipro+genta" group was admitted to the intensive care unit with septicaemia. CONCLUSIONThe addition of I/M gentamicin to oral ciprofloxacin is a safe and effective prophylactic antibiotic regime in reducing the incidence of post-TRPB sepsis. Introduction: Infection-related complications after transrectal ultrasound guided prostatic biopsy (TRPB) could be life threatening. Our centre observed sepsis after TRPB despite prophylactic oral ciprofloxacin. We reviewed all cases of post-TRPB sepsis with their bacteriology and evaluated if the addition of intramuscular (I/M) gentamicin to standard prophylaxis before TRPB could reduce its incidence. Materials and Methods: In a single urological centre, we performed an interventional study that compared a prospective group with retrospective control. The latter is known as the “cipro-only” group included consecutive patients who underwent TRPB between 1 September 2003 and 31 August 2004. The addition of I/M gentamicin 80mg half an hour before TRPB started on 1 September 2004. All subsequent patients who underwent TRPB until 31 August 2005 were included in the “cipro+genta” group. Patients who did not receive the studied antibiotics were excluded. Results: There were 374 patients in the “cipro+genta” group and 367 patients in the “cipro-only” group with comparable profiles. There were 12 cases of post-TRPB sepsis in the “cipro-only” group and 5 cases in the “cipro+genta” group. Ciprofloxacin-resistant Escherichia coli (E. coli) was the only pathogen isolated in both groups. In the “cipro-only” group, 9 patients had positive blood cultures and 8 were sensitive to gentamicin. In the “cipro+genta” group, the only positive E. coli was gentamicin-resistant. One patient in the “cipro+genta” group was admitted to the intensive care unit with septicaemia. Conclusion: The addition of I/M gentamicin to oral ciprofloxacin is a safe and effective prophylactic antibiotic regime in reducing the incidence of post-TRPB sepsis. Key words: Antibiotics, Infection, Prophylaxis, Prostate Biopsy Infection-related complications after transrectal ultrasound guided prostatic biopsy (TRPB) could be life threatening. Our centre observed sepsis after TRPB despite prophylactic oral ciprofloxacin. We reviewed all cases of post-TRPB sepsis with their bacteriology and evaluated if the addition of intramuscular (I/M) gentamicin to standard prophylaxis before TRPB could reduce its incidence. In a single urological centre, we performed an interventional study that compared a prospective group with retrospective control. The latter is known as the "cipro-only" group included consecutive patients who underwent TRPB between 1 September 2003 and 31 August 2004. The addition of I/M gentamicin 80 mg half an hour before TRPB started on 1 September 2004. All subsequent patients who underwent TRPB until 31 August 2005 were included in the "cipro+genta" group. Patients who did not receive the studied antibiotics were excluded. There were 374 patients in the "cipro+genta" group and 367 patients in the "cipro-only" group with comparable profiles. There were 12 cases of post-TRPB sepsis in the "cipro-only" group and 5 cases in the "cipro+genta" group. Ciprofloxacin-resistant Escherichia coli (E. coli) was the only pathogen isolated in both groups. In the "cipro-only" group, 9 patients had positive blood cultures and 8 were sensitive to gentamicin. In the "cipro+genta" group, the only positive E. coli was gentamicin-resistant. One patient in the "cipro+genta" group was admitted to the intensive care unit with septicaemia. The addition of I/M gentamicin to oral ciprofloxacin is a safe and effective prophylactic antibiotic regime in reducing the incidence of post-TRPB sepsis. |
Author | Ho, Henry S S Tan, Yeh Hong Ng, Lay Guat Cheng, Christopher W S Yeo, Mavis |
Author_xml | – sequence: 1 givenname: Henry S S surname: Ho fullname: Ho, Henry S S email: ho.henry.s.s@gmail.com organization: Department of Urology, Singapore General Hospital, Singapore. ho.henry.s.s@gmail.com – sequence: 2 givenname: Lay Guat surname: Ng fullname: Ng, Lay Guat – sequence: 3 givenname: Yeh Hong surname: Tan fullname: Tan, Yeh Hong – sequence: 4 givenname: Mavis surname: Yeo fullname: Yeo, Mavis – sequence: 5 givenname: Christopher W S surname: Cheng fullname: Cheng, Christopher W S |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19347074$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1046/j.1464-410x.2002.02991.x 10.1016/s0090-4295(98)00313-6 10.1097/00005392-199812010-00045 10.1046/j.1464-410x.2000.00576.x 10.1016/s0022-5347(17)38664-0 10.1007/s00345-005-0024-4 10.1016/s0090-4295(98)00296-9 10.1097/00005392-200004000-00004 10.1097/01.ju.0000061280.23447.29 10.1097/00005392-199901000-00066 10.1097/00005392-200007000-00019 10.1016/s0090-4295(02)01958-1 10.1111/j.1442-2042.2007.01869.x 10.1002/jcu.20168 10.1046/j.1464-410x.1997.00146.x 10.1097/00005392-200209000-00028 |
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Snippet | Infection-related complications after transrectal ultrasound guided prostatic biopsy (TRPB) could be life threatening. Our centre observed sepsis after TRPB... Introduction: Infection-related complications after transrectal ultrasound guided prostatic biopsy (TRPB) could be life threatening. Our centre observed sepsis... INTRODUCTIONInfection-related complications after transrectal ultrasound guided prostatic biopsy (TRPB) could be life threatening. Our centre observed sepsis... |
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SubjectTerms | Administration, Oral Adult Aged Antibiotic Prophylaxis - methods Biopsy Ciprofloxacin - administration & dosage Ciprofloxacin - therapeutic use Drug Resistance, Bacterial Escherichia coli - drug effects Escherichia coli - isolation & purification Gentamicins - administration & dosage Humans Injections, Intramuscular Male Middle Aged Prospective Studies Prostate - diagnostic imaging Prostate - pathology Rectum Ultrasonography |
Title | Intramuscular gentamicin improves the efficacy of ciprofloxacin as an antibiotic prophylaxis for transrectal prostate biopsy |
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