The Implication of Serum Autoantibodies in Prognosis of Canine Mammary Tumors
Canine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery. Identification of serum prognostic biomarkers holds the potential to facilitate prediction of disease outcomes. We have identified CMT-associated...
Saved in:
| Published in | Animals (Basel) Vol. 12; no. 18; p. 2463 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
18.09.2022
MDPI |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Canine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery. Identification of serum prognostic biomarkers holds the potential to facilitate prediction of disease outcomes. We have identified CMT-associated autoantibodies against thymidylate synthetase (TYMS), insulin-like growth factor-binding protein 5 (IGFBP5), hyaluronan and proteoglycan link protein 1 (HAPLN1), and anterior gradient 2 (AGR2), i.e., TYMS-AAb, IGFBP5-AAb, HAPLN1-AAb, and AGR2-AAb, respectively, by conducting serological enzyme-linked immunosorbent assays (ELISA). Herein we assessed serum AAb levels in 11 MMT dogs before and after surgery, demonstrating that IGFBP5-AAb and HAPLN1-AAb significantly decrease at 3- and 12-months post-surgery (p < 0.05). We evaluated the correlation between the presurgical AAb level and overall survival (OS) of 90 CMT dogs after surgery. Kaplan-Meier survival analysis reveals that IGFBP5-AAbHIgh and TYMS-AAbHigh are significantly correlated with worse OS (p = 0.017 and p = 0.029, respectively), while AGR2-AAbLow is correlated with somewhat poorer OS (p = 0.086). Areas under a time-dependent receiver operating characteristic curve (AUC) of IGFBP5-AAb and TYMS-AAb in predicting OS of MMT dogs are 0.611 and 0.616, respectively. Notably, MMT dogs presenting TYMS-AAbHigh/IGFBP5-AAbHigh/AGR2-AAbLow have worst OS (p = 0.0004). This study reveals an association between the serum AAb level and CMT prognosis. |
|---|---|
| AbstractList | Canine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery. Identification of serum prognostic biomarkers holds the potential to facilitate prediction of disease outcomes. We have identified CMT-associated autoantibodies against thymidylate synthetase (TYMS), insulin-like growth factor-binding protein 5 (IGFBP5), hyaluronan and proteoglycan link protein 1 (HAPLN1), and anterior gradient 2 (AGR2), i.e., TYMS-AAb, IGFBP5-AAb, HAPLN1-AAb, and AGR2-AAb, respectively, by conducting serological enzyme-linked immunosorbent assays (ELISA). Herein we assessed serum AAb levels in 11 MMT dogs before and after surgery, demonstrating that IGFBP5-AAb and HAPLN1-AAb significantly decrease at 3- and 12-months post-surgery (p < 0.05). We evaluated the correlation between the presurgical AAb level and overall survival (OS) of 90 CMT dogs after surgery. Kaplan-Meier survival analysis reveals that IGFBP5-AAbHIgh and TYMS-AAbHigh are significantly correlated with worse OS (p = 0.017 and p = 0.029, respectively), while AGR2-AAbLow is correlated with somewhat poorer OS (p = 0.086). Areas under a time-dependent receiver operating characteristic curve (AUC) of IGFBP5-AAb and TYMS-AAb in predicting OS of MMT dogs are 0.611 and 0.616, respectively. Notably, MMT dogs presenting TYMS-AAbHigh/IGFBP5-AAbHigh/AGR2-AAbLow have worst OS (p = 0.0004). This study reveals an association between the serum AAb level and CMT prognosis.Canine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery. Identification of serum prognostic biomarkers holds the potential to facilitate prediction of disease outcomes. We have identified CMT-associated autoantibodies against thymidylate synthetase (TYMS), insulin-like growth factor-binding protein 5 (IGFBP5), hyaluronan and proteoglycan link protein 1 (HAPLN1), and anterior gradient 2 (AGR2), i.e., TYMS-AAb, IGFBP5-AAb, HAPLN1-AAb, and AGR2-AAb, respectively, by conducting serological enzyme-linked immunosorbent assays (ELISA). Herein we assessed serum AAb levels in 11 MMT dogs before and after surgery, demonstrating that IGFBP5-AAb and HAPLN1-AAb significantly decrease at 3- and 12-months post-surgery (p < 0.05). We evaluated the correlation between the presurgical AAb level and overall survival (OS) of 90 CMT dogs after surgery. Kaplan-Meier survival analysis reveals that IGFBP5-AAbHIgh and TYMS-AAbHigh are significantly correlated with worse OS (p = 0.017 and p = 0.029, respectively), while AGR2-AAbLow is correlated with somewhat poorer OS (p = 0.086). Areas under a time-dependent receiver operating characteristic curve (AUC) of IGFBP5-AAb and TYMS-AAb in predicting OS of MMT dogs are 0.611 and 0.616, respectively. Notably, MMT dogs presenting TYMS-AAbHigh/IGFBP5-AAbHigh/AGR2-AAbLow have worst OS (p = 0.0004). This study reveals an association between the serum AAb level and CMT prognosis. Canine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery. Identification of serum prognostic biomarkers holds the potential to facilitate prediction of disease outcomes. We have identified CMT-associated autoantibodies against thymidylate synthetase (TYMS), insulin-like growth factor-binding protein 5 (IGFBP5), hyaluronan and proteoglycan link protein 1 (HAPLN1), and anterior gradient 2 (AGR2), i.e., TYMS-AAb, IGFBP5-AAb, HAPLN1-AAb, and AGR2-AAb, respectively, by conducting serological enzyme-linked immunosorbent assays (ELISA). Herein we assessed serum AAb levels in 11 MMT dogs before and after surgery, demonstrating that IGFBP5-AAb and HAPLN1-AAb significantly decrease at 3- and 12-months post-surgery (p < 0.05). We evaluated the correlation between the presurgical AAb level and overall survival (OS) of 90 CMT dogs after surgery. Kaplan-Meier survival analysis reveals that IGFBP5-AAbᴴᴵᵍʰ and TYMS-AAbᴴⁱᵍʰ are significantly correlated with worse OS (p = 0.017 and p = 0.029, respectively), while AGR2-AAbᴸᵒʷ is correlated with somewhat poorer OS (p = 0.086). Areas under a time-dependent receiver operating characteristic curve (AUC) of IGFBP5-AAb and TYMS-AAb in predicting OS of MMT dogs are 0.611 and 0.616, respectively. Notably, MMT dogs presenting TYMS-AAbᴴⁱᵍʰ/IGFBP5-AAbᴴⁱᵍʰ/AGR2-AAbᴸᵒʷ have worst OS (p = 0.0004). This study reveals an association between the serum AAb level and CMT prognosis. Simple SummaryCanine mammary tumor (CMT) is prevalent in female dogs. As tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery, serum prognostic biomarkers are needed to facilitate prediction of disease outcomes. We have identified CMT-associated autoantibodies, namely TYMS-AAb, IGFBP5-AAb, HAPLN1-AAb, and AGR2-AAb, which are present in serum of CMT dogs. In this study, we demonstrated that the serum AAb levels decreased at 3- and 12-months post-surgery in 11 MMT dogs. We also evaluated the correlation between the presurgical AAb level and overall survival (OS) of 90 CMT dogs after surgery. Data reveal that higher levels of IGFBP5-AAb and TYMS-AAb are significantly correlated with worse OS. On the contrary, a lower level of AGR2-AAb is correlated with poorer OS. Notably, MMT dogs presenting higher levels of TYMS-AAb and IGFBP5-AAb plus a lower level of AGR2-AAb have worst OS. This is the first study revealing an association between serum AAb levels and clinical outcomes of CMT and provides a starting point to verify the validity of utilizing this AAb panel in prediction of tumor relapse and therapy responses.AbstractCanine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery. Identification of serum prognostic biomarkers holds the potential to facilitate prediction of disease outcomes. We have identified CMT-associated autoantibodies against thymidylate synthetase (TYMS), insulin-like growth factor-binding protein 5 (IGFBP5), hyaluronan and proteoglycan link protein 1 (HAPLN1), and anterior gradient 2 (AGR2), i.e., TYMS-AAb, IGFBP5-AAb, HAPLN1-AAb, and AGR2-AAb, respectively, by conducting serological enzyme-linked immunosorbent assays (ELISA). Herein we assessed serum AAb levels in 11 MMT dogs before and after surgery, demonstrating that IGFBP5-AAb and HAPLN1-AAb significantly decrease at 3- and 12-months post-surgery (p < 0.05). We evaluated the correlation between the presurgical AAb level and overall survival (OS) of 90 CMT dogs after surgery. Kaplan-Meier survival analysis reveals that IGFBP5-AAbHIgh and TYMS-AAbHigh are significantly correlated with worse OS (p = 0.017 and p = 0.029, respectively), while AGR2-AAbLow is correlated with somewhat poorer OS (p = 0.086). Areas under a time-dependent receiver operating characteristic curve (AUC) of IGFBP5-AAb and TYMS-AAb in predicting OS of MMT dogs are 0.611 and 0.616, respectively. Notably, MMT dogs presenting TYMS-AAbHigh/IGFBP5-AAbHigh/AGR2-AAbLow have worst OS (p = 0.0004). This study reveals an association between the serum AAb level and CMT prognosis. Canine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery. Identification of serum prognostic biomarkers holds the potential to facilitate prediction of disease outcomes. We have identified CMT-associated autoantibodies against thymidylate synthetase (TYMS), insulin-like growth factor-binding protein 5 (IGFBP5), hyaluronan and proteoglycan link protein 1 (HAPLN1), and anterior gradient 2 (AGR2), i.e., TYMS-AAb, IGFBP5-AAb, HAPLN1-AAb, and AGR2-AAb, respectively, by conducting serological enzyme-linked immunosorbent assays (ELISA). Herein we assessed serum AAb levels in 11 MMT dogs before and after surgery, demonstrating that IGFBP5-AAb and HAPLN1-AAb significantly decrease at 3- and 12-months post-surgery (p < 0.05). We evaluated the correlation between the presurgical AAb level and overall survival (OS) of 90 CMT dogs after surgery. Kaplan-Meier survival analysis reveals that IGFBP5-AAbHIgh and TYMS-AAbHigh are significantly correlated with worse OS (p = 0.017 and p = 0.029, respectively), while AGR2-AAbLow is correlated with somewhat poorer OS (p = 0.086). Areas under a time-dependent receiver operating characteristic curve (AUC) of IGFBP5-AAb and TYMS-AAb in predicting OS of MMT dogs are 0.611 and 0.616, respectively. Notably, MMT dogs presenting TYMS-AAbHigh/IGFBP5-AAbHigh/AGR2-AAbLow have worst OS (p = 0.0004). This study reveals an association between the serum AAb level and CMT prognosis. |
| Author | Yang, Youngsen Yuan, Stephen Hsien-Chi Chou, Pei-Yi Liu, Hao-Ping Chang, Shih-Chieh |
| AuthorAffiliation | 1 Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan 2 Division of Hematology-Oncology, Department of Internal Medicine, Taichung, Veterans General Hospital, Taichung 40705, Taiwan |
| AuthorAffiliation_xml | – name: 1 Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan – name: 2 Division of Hematology-Oncology, Department of Internal Medicine, Taichung, Veterans General Hospital, Taichung 40705, Taiwan |
| Author_xml | – sequence: 1 givenname: Stephen Hsien-Chi orcidid: 0000-0001-8243-3704 surname: Yuan fullname: Yuan, Stephen Hsien-Chi – sequence: 2 givenname: Shih-Chieh surname: Chang fullname: Chang, Shih-Chieh – sequence: 3 givenname: Pei-Yi surname: Chou fullname: Chou, Pei-Yi – sequence: 4 givenname: Youngsen surname: Yang fullname: Yang, Youngsen – sequence: 5 givenname: Hao-Ping orcidid: 0000-0001-5915-5128 surname: Liu fullname: Liu, Hao-Ping |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36139323$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkktr3DAUhUVJaNI0q-6LoZtCmVYv67EphKGPgYQWOl0LWb6eaLClqWQX8u8jZ9IwCV1EG70-HR3pnlfoKMQACL0h-CNjGn-ywRNKFOWCvUCnFEuxoILURwfjE3Se8xaXJmtGavISnTBBmGaUnaKr9TVUq2HXe2dHH0MVu-oXpGmoLqYx2jD6JrYecuVD9TPFTYjZ5xlalpsDVFd2GGy6qdbTEFN-jY4722c4v-_P0O-vX9bL74vLH99Wy4vLheNMjQtFFGu1pUAbRTtBdAdlThouSNcqUDXjmIHCjWWKq87WjuOuGJayaaUmjJ2h1V63jXZrdsnPHky03twtxLQxNo3e9WAazop8KxpCMW-VsA4AWgta2wYz3hWtz3ut3dQM0DoIY7L9I9HHO8Ffm038azTXNZWzmff3Ain-mSCPZvDZQd_bAHHKhkrK5hqJ56BECi255gV99wTdximF8qszJbgUgohCvT00_-D6X4EL8GEPuBRzTtA9IASbOUHmIEGFJk9o58e7XJSX-_6_Z24BCqPHXg |
| CitedBy_id | crossref_primary_10_1080_01652176_2024_2435978 |
| Cites_doi | 10.1136/jclinpath-2012-201278 10.1074/jbc.M117.799908 10.4142/jvs.2021.22.e75 10.1016/j.autrev.2022.103041 10.1111/1440-1681.13415 10.1177/1040638715592445 10.1016/j.ebiom.2020.102674 10.1038/nrc3720 10.1007/s10549-016-3801-4 10.3390/ani11102923 10.1158/2159-8290.CD-18-0168 10.1111/j.0006-341X.2000.00337.x 10.1002/prca.201800151 10.1186/1746-6148-9-1 10.1074/jbc.M111.275529 10.1097/MD.0000000000018487 10.15252/emmm.201810120 10.1177/0300985818806968 10.1177/0300985810393258 10.18632/oncotarget.4114 10.1186/s12885-018-4022-5 10.1038/bjc.2017.171 10.7554/eLife.13887 10.3390/cancers13215559 10.1186/s13028-018-0417-1 10.3390/ani11041115 10.1101/2020.04.25.061655 10.1111/cas.15021 10.1016/j.domaniend.2004.06.009 10.1016/j.bios.2019.111315 10.1158/1078-0432.CCR-08-2755 10.1177/0300985817698208 10.1111/vco.12657 |
| ContentType | Journal Article |
| Copyright | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2022 by the authors. 2022 |
| Copyright_xml | – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2022 by the authors. 2022 |
| DBID | AAYXX CITATION NPM ABUWG AFKRA AZQEC BENPR CCPQU DWQXO PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI 7X8 7S9 L.6 5PM DOA |
| DOI | 10.3390/ani12182463 |
| DatabaseName | CrossRef PubMed ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central ProQuest One Academic Middle East (New) ProQuest One Academic UKI Edition ProQuest Central Essentials ProQuest Central Korea ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic AGRICOLA Publicly Available Content Database PubMed CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Zoology |
| EISSN | 2076-2615 |
| ExternalDocumentID | oai_doaj_org_article_b439fed6b1204d86aceeedae99ab034f PMC9495273 36139323 10_3390_ani12182463 |
| Genre | Journal Article |
| GeographicLocations | United States--US Taiwan |
| GeographicLocations_xml | – name: Taiwan – name: United States--US |
| GrantInformation_xml | – fundername: Taichung Veterans General Hospital/National Chung Hsing University Joint Research Program grantid: TCVGH-NCHU1117616 – fundername: Ministry of Science and Technology, Taiwan grantid: MOST 109-2320-B-005-011- – fundername: VMTH/CVM Joint Research Program, National Chung Hsing University grantid: VMTH-CVM-111 – fundername: Ministry of Science and Technology, Taiwan grantid: MOST 111-2313-B-005-041- – fundername: VMTH/CVM Joint Research Program, National Chung Hsing University, Taiwan grantid: VMTH-CVM-110 – fundername: Ministry of Science and Technology, Taiwan grantid: MOST 109-2320-B-005-011-; MOST 111-2313-B-005-041- |
| GroupedDBID | 5VS 7XC 8FE 8FH AAFWJ AAHBH AAYXX ABDBF ACUHS AFKRA AFPKN ALMA_UNASSIGNED_HOLDINGS APEBS BENPR CCPQU CITATION DIK EAD EAP EPL ESX GROUPED_DOAJ HYE IAO ITC LK8 M48 MODMG M~E OK1 OZF PGMZT PHGZM PHGZT PIMPY PROAC RPM TUS ZBA ATCPS BBNVY BHPHI HCIFZ ISR M0K M7P NPM PATMY PYCSY ABUWG AZQEC DWQXO PKEHL PQEST PQQKQ PQUKI 7X8 7S9 L.6 5PM PUEGO |
| ID | FETCH-LOGICAL-c438t-8183d9a2e2b82f619fe3d91b461fd8e853403e80ba3848fa5c40f39377bd79133 |
| IEDL.DBID | DOA |
| ISSN | 2076-2615 |
| IngestDate | Wed Aug 27 01:24:25 EDT 2025 Thu Aug 21 18:39:49 EDT 2025 Thu Jul 10 17:14:03 EDT 2025 Thu Jul 10 17:25:51 EDT 2025 Mon Jun 30 11:03:04 EDT 2025 Thu Jan 02 22:52:44 EST 2025 Tue Jul 01 01:55:57 EDT 2025 Thu Apr 24 23:02:31 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 18 |
| Keywords | canine mammary tumor autoantibody serum prognosis survival |
| Language | English |
| License | https://creativecommons.org/licenses/by/4.0 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c438t-8183d9a2e2b82f619fe3d91b461fd8e853403e80ba3848fa5c40f39377bd79133 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0001-5915-5128 0000-0001-8243-3704 |
| OpenAccessLink | https://doaj.org/article/b439fed6b1204d86aceeedae99ab034f |
| PMID | 36139323 |
| PQID | 2716476616 |
| PQPubID | 2032438 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_b439fed6b1204d86aceeedae99ab034f pubmedcentral_primary_oai_pubmedcentral_nih_gov_9495273 proquest_miscellaneous_2723121863 proquest_miscellaneous_2717697494 proquest_journals_2716476616 pubmed_primary_36139323 crossref_primary_10_3390_ani12182463 crossref_citationtrail_10_3390_ani12182463 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20220918 |
| PublicationDateYYYYMMDD | 2022-09-18 |
| PublicationDate_xml | – month: 9 year: 2022 text: 20220918 day: 18 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Animals (Basel) |
| PublicationTitleAlternate | Animals (Basel) |
| PublicationYear | 2022 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Rasotto (ref_2) 2017; 54 Cyll (ref_14) 2017; 117 Song (ref_9) 2021; 22 Lebeau (ref_32) 2017; 292 Yadav (ref_13) 2019; 139 ref_11 ref_10 Allan (ref_19) 2004; 27 ref_31 Canadas (ref_3) 2019; 56 Fu (ref_16) 2019; 98 Heagerty (ref_29) 2000; 56 Tabuchi (ref_33) 2016; 157 Wang (ref_22) 2015; 6 Baxter (ref_21) 2014; 14 Kaszak (ref_6) 2018; 60 Song (ref_17) 2021; 48 Ecker (ref_24) 2019; 9 Chang (ref_25) 2021; 19 Goldschmidt (ref_1) 2011; 48 Fessart (ref_28) 2016; 5 Wu (ref_15) 2019; 13 Li (ref_34) 2020; 53 Qiu (ref_30) 2021; 112 Liang (ref_20) 2013; 66 Maurel (ref_27) 2019; 11 Campos (ref_7) 2015; 27 ref_8 Sexauer (ref_12) 2022; 21 ref_5 Higa (ref_26) 2011; 286 ref_4 Shan (ref_18) 2018; 16 Ivanova (ref_23) 2009; 15 |
| References_xml | – volume: 66 start-page: 573 year: 2013 ident: ref_20 article-title: IGFBP-5 overexpression as a poor prognostic factor in patients with urothelial carcinomas of upper urinary tracts and urinary bladder publication-title: J. Clin. Pathol. doi: 10.1136/jclinpath-2012-201278 – volume: 292 start-page: 21180 year: 2017 ident: ref_32 article-title: Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor publication-title: J. Biol. Chem. doi: 10.1074/jbc.M117.799908 – volume: 22 start-page: e75 year: 2021 ident: ref_9 article-title: Evaluation of circulating PD-1 and PD-L1 as diagnostic biomarkers in dogs with tumors publication-title: J. Vet. Sci. doi: 10.4142/jvs.2021.22.e75 – volume: 21 start-page: 103041 year: 2022 ident: ref_12 article-title: Tumour- associated autoantibodies as prognostic cancer biomarkers- a review publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2022.103041 – volume: 48 start-page: 279 year: 2021 ident: ref_17 article-title: Diagnostic and prognostic value of thymidylate synthase expression in breast cancer publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/1440-1681.13415 – volume: 27 start-page: 531 year: 2015 ident: ref_7 article-title: Prognostic significance of tissue and serum HER2 and MUC1 in canine mammary cancer publication-title: J. Vet. Diagn. Investig. doi: 10.1177/1040638715592445 – volume: 53 start-page: 102674 year: 2020 ident: ref_34 article-title: Longitudinal serum autoantibody repertoire profiling identifies surgery-associated biomarkers in lung adenocarcinoma publication-title: EBioMedicine doi: 10.1016/j.ebiom.2020.102674 – volume: 14 start-page: 329 year: 2014 ident: ref_21 article-title: IGF binding proteins in cancer: Mechanistic and clinical insights publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3720 – volume: 157 start-page: 55 year: 2016 ident: ref_33 article-title: Protective effect of naturally occurring anti-HER2 autoantibodies on breast cancer publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-016-3801-4 – ident: ref_8 doi: 10.3390/ani11102923 – volume: 9 start-page: 82 year: 2019 ident: ref_24 article-title: Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-18-0168 – volume: 56 start-page: 337 year: 2000 ident: ref_29 article-title: Time-dependent ROC curves for censored survival data and a diagnostic marker publication-title: Biometrics doi: 10.1111/j.0006-341X.2000.00337.x – volume: 13 start-page: 1800151 year: 2019 ident: ref_15 article-title: Proteome analyses reveal positive association of COL2A1, MPO, TYMS, and IGFBP5 with canine mammary gland malignancy publication-title: Proteom. Clin. Appl. doi: 10.1002/prca.201800151 – ident: ref_5 doi: 10.1186/1746-6148-9-1 – volume: 286 start-page: 44855 year: 2011 ident: ref_26 article-title: Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.275529 – volume: 98 start-page: e18487 year: 2019 ident: ref_16 article-title: TYMS presents a novel biomarker for diagnosis and prognosis in patients with pancreatic cancer publication-title: Medicine doi: 10.1097/MD.0000000000018487 – volume: 11 start-page: e10120 year: 2019 ident: ref_27 article-title: Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation publication-title: EMBO Mol. Med. doi: 10.15252/emmm.201810120 – volume: 56 start-page: 208 year: 2019 ident: ref_3 article-title: Canine Mammary Tumors: Comparison of Classification and Grading Methods in a Survival Study publication-title: Vet. Pathol. doi: 10.1177/0300985818806968 – volume: 48 start-page: 117 year: 2011 ident: ref_1 article-title: Classification and grading of canine mammary tumors publication-title: Vet. Pathol. doi: 10.1177/0300985810393258 – volume: 6 start-page: 20636 year: 2015 ident: ref_22 article-title: Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells publication-title: Oncotarget doi: 10.18632/oncotarget.4114 – ident: ref_31 doi: 10.1186/s12885-018-4022-5 – volume: 117 start-page: 367 year: 2017 ident: ref_14 article-title: Tumour heterogeneity poses a significant challenge to cancer biomarker research publication-title: Br. J. Cancer doi: 10.1038/bjc.2017.171 – volume: 5 start-page: e13887 year: 2016 ident: ref_28 article-title: Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties publication-title: eLife doi: 10.7554/eLife.13887 – ident: ref_11 doi: 10.3390/cancers13215559 – volume: 60 start-page: 66 year: 2018 ident: ref_6 article-title: Current biomarkers of canine mammary tumors publication-title: Acta Vet. Scand. doi: 10.1186/s13028-018-0417-1 – ident: ref_4 doi: 10.3390/ani11041115 – ident: ref_10 doi: 10.1101/2020.04.25.061655 – volume: 16 start-page: 3274 year: 2018 ident: ref_18 article-title: Thymidylate synthase predicts poor response to pemetrexed chemotherapy in patients with advanced breast cancer publication-title: Oncol. Lett. – volume: 112 start-page: 3388 year: 2021 ident: ref_30 article-title: Identification of novel autoantibody signatures and evaluation of a panel of autoantibodies in breast cancer publication-title: Cancer Sci. doi: 10.1111/cas.15021 – volume: 27 start-page: 257 year: 2004 ident: ref_19 article-title: The role of IGFBP-5 in mammary gland development and involution publication-title: Domest. Anim. Endocrinol. doi: 10.1016/j.domaniend.2004.06.009 – volume: 139 start-page: 111315 year: 2019 ident: ref_13 article-title: Autoantibodies as diagnostic and prognostic cancer biomarker: Detection techniques and approaches publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2019.111315 – volume: 15 start-page: 2602 year: 2009 ident: ref_23 article-title: Protumorigenic role of HAPLN1 and its IgV domain in malignant pleural mesothelioma publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-2755 – volume: 54 start-page: 571 year: 2017 ident: ref_2 article-title: Prognostic Significance of Canine Mammary Tumor Histologic Subtypes: An Observational Cohort Study of 229 Cases publication-title: Vet. Pathol. doi: 10.1177/0300985817698208 – volume: 19 start-page: 172 year: 2021 ident: ref_25 article-title: Significant association of serum autoantibodies to TYMS, HAPLN1 and IGFBP5 with early stage canine malignant mammary tumours publication-title: Vet. Comp. Oncol. doi: 10.1111/vco.12657 |
| SSID | ssj0000753151 |
| Score | 2.239301 |
| Snippet | Canine mammary tumor (CMT) is the most prevalent neoplasm in female dogs. Tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery.... Simple SummaryCanine mammary tumor (CMT) is prevalent in female dogs. As tumor recurrence and metastasis occur in malignant CMT (MMT) dogs after surgery, serum... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 2463 |
| SubjectTerms | Antigens autoantibodies autoantibody Biomarkers blood serum Cancer canine Dogs Enzymes females hyaluronic acid insulin-like growth factor binding proteins mammary neoplasms (animal) mammary tumor Mastectomy Medical prognosis metastasis Peptides Pets prediction prognosis Proteins proteoglycans serum surgery survival thymidylate synthase Tumors |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dSxwxEA-tUuiL9NuztqTgU2FxN8lmkydRUWzhRIqC9GVJNkm7UDd6d_v_O7OXW70iPu5mHmYn8_Gb7GSGkD0tnXHWsyx3ockEQPRMmWCz0gTDmGukKfGi8PRcnl2Jn9fldTpwm6eyypVPHBy1iw2eke8zBPYVRBN5cHuX4dQo_LuaRmi8JJvgghUkX5tHJ-cXv8ZTFgiIHGLa8mIeh_x-33RtgV3LheRroWjo2P8UzPy_WvJR-Dl9Q7YSbqSHy41-S1747h159TsOp-LvyRS2m_54qA6nMVBwA_0NPewXEaTX2oj1grTt6MUsYnVdO0eiY-C083Rqhjts9LK_ibP5B3J1enJ5fJalSQlZI7haZBB1udOGeWYVCyDw4OG5sCD74JSHkCxy7lVuDVdCBVM2Ig_YCq-yrtKQpn4kG13s_DahheOyLJxuQtBCV8aUYPMyaFexpslZmJDvK6HVTWojjtMs_tWQTqCE60cSnpC9kfh22T3jabIjlP5Igi2vhxdx9qdOFlRbgE7BO2kLlgunpIHw7p3xWhubcwGM7a72rk52OK8ftGZCvo3LYEH4W8R0PvYDTSUhrdLiORrAwTi-C3j9tFSHkVsOiAhQMKxUa4qy9jnrK137d-jkDRLGBng7z7P-mbxmeOkCB1eoXbKxmPX-C0Chhf2a9P0ey0EL5g priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZKERIXRHkuFGSknpACie049qGqSkVVkBZx6EoVl8iO7RLUxm12I8G_ZybJbrvVihPHxBNpMuPJfBPPg5A9LZ1x1rMkdaFKBED0RJlgk9wEw5irpMmxUHj6TZ7MxNez_GyLLIdxjgKcbwztcJ7UrL348Pv6zwEY_D5GnBCyfzRNnWEjciH5PXIfXFKBFjodcf6v4bSOg2sb6vPuPrPmkfrG_ZvQ5t2kyVte6PgxeTTCR3o46HuHbPnmCXnwI_Y_x5-SKWidfrlJEqcxUPgadJf0sFtEEGJtI6YN0rqh39uISXb1HImOgNPG06npS9noaXcZ2_kzMjv-fHp0kowDE5JKcLVIwPlypw3zzCoWQO7Bw3VmQQXBKQ-eWaTcq9QaroQKJq9EGrAjXmFdoSFafU62m9j4l4Rmjss8c7oKQQtdGJOD6cugXcGqKmVhQt4vhVZWYzdxHGpxUUJUgRIub0l4QvZWxFdDE43NZJ9Q-isS7Hzd34jteTkaUmkBQQXvpM1YKpySBry8d8ZrbWzKBTC2u9RdudxNJcOosAAoIifk3WoZDAlPR0zjY9fTFBKiKy3-RQNwGKd4Aa8vhu2w4pYDMAIwDCvF2kZZe531lab-2Tf0BgljH7xX_-P9X5OHDCs0cMqF2iXbi7bzbwA3Lezb3ib-Am9eGqQ priority: 102 providerName: Scholars Portal |
| Title | The Implication of Serum Autoantibodies in Prognosis of Canine Mammary Tumors |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36139323 https://www.proquest.com/docview/2716476616 https://www.proquest.com/docview/2717697494 https://www.proquest.com/docview/2723121863 https://pubmed.ncbi.nlm.nih.gov/PMC9495273 https://doaj.org/article/b439fed6b1204d86aceeedae99ab034f |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3dS-QwEA-iCPci6n1Yv8jBPgnFNknT5FFF8Q5WRFaQeylJk3CVsz12t_-_M21ddw85X3wptJmH5NeZzEw7-Q0hIy2dcdazOHGhjAWE6LEywcaZCYYxV0qT4UHh8Y28vhc_H7KHpVZfWBPW0wP3wJ1a8JjBO2lTlginpIFd3TvjtTY24SLg7gs-bymZeux_z3HwZf2BPA55_ampqxTZyoXkKy6oY-p_K7z8t0pyye1cbZOtIV6kZ_08d8iar3fJ5q-m-xr-mYzhNdMfr1XhtAkUzL99omftvAHUKttgnSCtano7bbCqrpqh0AXMtPZ0bLqza3TSPjXT2Rdyf3U5ubiOhw4JcSm4msfgbbnThnlmFQsAdPBwn1rAPDjlwRWLhHuVWMOVUMFkpUgCUuDl1uUa0tOvZL1uar9HaOq4zFKnyxC00LkxGdi6DNrlrCwTFiJy8gJaUQ704djF4k8BaQQiXCwhHJHRQvhvz5rxttg5or8QQarr7gEoQDEoQPGeAkTk8OXdFYP9zQqGaWAOsYeMyPfFMFgO_g4xtW_aTiaXkE5p8T8ZiH-xbRfM9VuvDovZcoiEIPqFkXxFUVaWszpSV787Bm9AGInv9j9i_QfkE8MjGdjWQh2S9fm09UcQKM3tMdk4v7y5vTvubAOuY6GeAQRnF2M |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqrRBcEG8WChipXJCiJrbz8AGhtrTapd1VhbZSxSXYsQ2RaFz2IcSf4jcyk1e7qOqtx8RzmIzn8dmZByHbMjHKaMuC0LgiEADRg0w5HcTKKcZMkagYC4Un02R0Kj6fxWcb5G9XC4NplZ1PrB218QXeke8wBPYpRJPk48WvAKdG4d_VboRGoxZH9s9vOLItPow_wf6-Y-zwYLY_CtqpAkEheLYMIEJxIxWzTGfMAXPOwnOkgU9nMgvhS4TcZqFWPBOZU3EhQodt41JtUhnhBSi4_E3B4SgzIJt7B9OTL_2tDgRgDjG0KQTkXIY7qioj7JIuEr4W-uoJAdfB2v-zM6-Eu8MH5H6LU-luo1gPyYatHpE7X319C_-YTEC96PgyG516R8HtrM7p7mrpYbdK7TE_kZYVPZl7zOYrF0i0D5xWlk5UXTNHZ6tzP188Iae3IsOnZFD5yj4nNDI8iSMjC-ekkKlSMfiYxEmTsqIImRuS953Q8qJtW47TM37mcHxBCedXJDwk2z3xRdOt43qyPZR-T4IttusXfv49by021wDVnDWJjlgoTJYogBPWKCul0iEXwNhWt3d5a_eL_FJLh-RtvwwWi79hVGX9qqZJEzjGSXETDeBuHBcGvD5r1KHnlgMCA9QNK-maoqx9zvpKVf6oO4eDhLHh3oubWX9D7o5mk-P8eDw9eknuMSz4wKEZ2RYZLOcr-wpg2FK_bnWfkm-3bW7_AHD6R5s |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqrUBcEG-2FDBSuSBFm9jOwweE-lp1KbtaoVaquAQ7tiFSm5TdjRB_jV_HTF7toqq3HhPPYTKex2dnHoTsyMgooy3zfOMyTwBE9xLltBcqpxgzWaRCLBSezqKjU_H5LDzbIH-7WhhMq-x8Yu2oTZnhHfmIIbCPIZpEI9emRcwPxp8uf3k4QQr_tHbjNBoVObZ_fsPxbflxcgB7_Z6x8eHJ_pHXThjwMsGTlQfRihupmGU6YQ4YdRaeAw08O5NYCGXC5zbxteKJSJwKM-E7bCEXaxPLAC9Dwf1vxnAq8gdkc-9wNv_a3_BAMOYQT5uiQM6lP1JFHmDHdBHxtTBYTwu4CeL-n6l5LfSNH5GHLWalu42SPSYbtnhC7n0r6xv5p2QKqkYnV5nptHQUXFB1QXerVQk7l-sScxVpXtD5osTMvnyJRPvAaWHpVNX1c_SkuigXy2fk9E5k-JwMirKwLwkNDI_CwMjMOSlkrFQI_iZy0sQsy3zmhuRDJ7Q0a1uY4ySN8xSOMijh9JqEh2SnJ75sOnfcTLaH0u9JsN12_aJc_Ehb6001wDZnTaQD5guTRAqghTXKSqm0zwUwtt3tXdr6gGV6pbFD8q5fBuvFXzKqsGVV08QRHOmkuI0GMDiODgNeXzTq0HPLAY0BAoeVeE1R1j5nfaXIf9ZdxEHC2Hxv63bW35L7YGbpl8ns-BV5wLD2A-dnJNtksFpU9jUgspV-06o-Jd_v2tr-AZOJS9A |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Implication+of+Serum+Autoantibodies+in+Prognosis+of+Canine+Mammary+Tumors&rft.jtitle=Animals+%28Basel%29&rft.au=Stephen+Hsien-Chi+Yuan&rft.au=Shih-Chieh+Chang&rft.au=Pei-Yi+Chou&rft.au=Youngsen+Yang&rft.date=2022-09-18&rft.pub=MDPI+AG&rft.eissn=2076-2615&rft.volume=12&rft.issue=18&rft.spage=2463&rft_id=info:doi/10.3390%2Fani12182463&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_b439fed6b1204d86aceeedae99ab034f |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2076-2615&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2076-2615&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2076-2615&client=summon |