Association of monocyte chemoattractant protein-1 (MCP-1)2518A/G polymorphism with proliferative diabetic retinopathy in northern Chinese type 2 diabetes

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 252; no. 12; pp. 1921 - 1926
• Main Authors: Dong, Li, lv, Xiao Ying, Wang, Bin Jie, Wang, Ye Qing, Mu, Hua, Feng, Zhuo Lei, Liu, Ping
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2014; Springer Nature B.V
• Subjects: Adult; Aged; Asian Continental Ancestry Group - genetics; Case-Control Studies; Chemokine CCL2 - genetics; China - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetic retinopathy; Diabetic Retinopathy - diagnosis; Diabetic Retinopathy - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotyping Techniques; Humans; Macular Edema - diagnosis; Macular Edema - genetics; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Retinal Disorders; China; Proliferative diabetic retinopathy (PDR); Type 2 diabetic retinopathy; Diabetic macular edema (DME); Single nucleotide polymorphism (SNP); Monocyte chemoattractant protein-1 (MCP-1)

Background The pathogenesis of proliferative diabetic retinopathy (PDR) remains poorly understood. Recent studies have implicated that monocyte chemoattractant protein-1 (MCP-1) is associated with diabetic microvascular or macrovascular complications. However, the relationship between single nucleot...