The intact nephron hypothesis as a model for renal drug handling

• Published in: European journal of clinical pharmacology Vol. 75; no. 2; pp. 147 - 156
• Main Authors: Pradhan, Sudeep, Duffull, Stephen B., Walker, Robert J., Wright, Daniel F. B.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2019; Springer Nature B.V
• Subjects: Animals; Biological Transport - physiology; Biomedical and Life Sciences; Biomedicine; Drug administration; Glomerular Filtration Rate - physiology; Humans; Hypotheses; Kidney Diseases - metabolism; Kidney Function Tests - methods; Metabolic Clearance Rate - physiology; Nephrons; Nephrons - metabolism; Pharmaceutical Preparations - metabolism; Pharmacology/Toxicology; Renal function; Review; Studies; Intact nephron hypothesis; Systematic review; Renal drug handling; Renal dose adjustment

Purpose The intact nephron hypothesis (INH) states that impaired renal function results from a reduction in the number of complete (intact) nephrons. Under this model, renal drug clearance is assumed to be a linear function of glomerular filtration while tubular handling is ignored. The aims of this...