Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer

• Published in: Scientific reports Vol. 7; no. 1; p. 41103
• Main Authors: Li, Xiong, Huang, Kecheng, Zhang, Qinghua, Zhou, Jin, Sun, Haiying, Tang, Fangxu, Zhou, Hang, Hu, Ting, Wang, Shaoshuai, Jia, Yao, Yang, Ru, Chen, Yile, Cheng, Xiaodong, Lv, Weiguo, Wu, Li, Xing, Hui, Wang, Lin, Zhou, Shasha, Yao, Yuan, Wang, Xiaoli, Suolang, Quzhen, Shen, Jian, Xi, Ling, Hu, Junbo, Wang, Hui, Chen, Gang, Gao, Qinglei, Xie, Xing, Wang, Shixuan, Li, Shuang, Ma, Ding
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.01.2017; Nature Publishing Group
• Subjects: 45/43; 692/4028/67/1517; 692/53/2423; Adult; Aged; Alleles; Antineoplastic Agents - administration & dosage; Asian Continental Ancestry Group; Biopsy; Cervical cancer; Cervix; Chemotherapy; Drug Therapy - methods; Etiology; Female; Genome-wide association studies; Genome-Wide Association Study; Genomes; Humanities and Social Sciences; Humans; Middle Aged; multidisciplinary; Platinum; Platinum - administration & dosage; Polymorphism, Single Nucleotide; Science; Science (multidisciplinary); Single-nucleotide polymorphism; Survival; Survival Analysis; Treatment Outcome; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - pathology; Young Adult

To identify genomic markers associated with the response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. A total of 596 patients with stage IA2-IIIB cervical cancer were enrolled in th...