Gene Expression in Kidney Cancer Is Associated with Cytogenetic Abnormalities, Metastasis Formation, and Patient Survival

• Published in: Clinical cancer research Vol. 11; no. 2; pp. 646 - 655
• Main Authors: SÜLTMANN, Holger, VON HEYDEBRECK, Anja, HUBER, Wolfgang, KUNER, Ruprecht, BUNESS, Andreas, VOGT, Markus, GUNAWAN, Bastian, VINGRON, Martin, FÜZESI, Laszlo, POUSTKA, Annemarie
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.01.2005
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Biomarkers, Tumor - metabolism; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - mortality; Carcinoma, Renal Cell - secondary; Chromosome Aberrations; Cytogenetic Analysis; Female; gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms - genetics; Kidney Neoplasms - mortality; Kidney Neoplasms - pathology; Male; Medical sciences; Middle Aged; Neoplasm Staging; Oligonucleotide Array Sequence Analysis; Pharmacology. Drug treatments; renal cell carcinoma; Human; Toxicity; Kidney cancer; Cytogenetics; Malignant tumor; Metastasis; Gene expression; Survival

Current diagnosis of renal cancer consists of histopathologic examination of tissue sections and classification into tumor stages and grades of malignancy. Until recently, molecular differences between tumor types were largely unknown. To examine such differences, we did gene expression measurements...