Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex

To determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex. Control (n = 95) and FD (n = 165) groups based on Rome III criteria were prospectively enrolled. Gastric mucosal mRNA expression levels of various TJPs (claudi...

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Published inJournal of neurogastroenterology and motility Vol. 26; no. 2; pp. 248 - 258
Main Authors Lee, Ju Yup, Kim, Nayoung, Choi, Yoon Jin, Park, Ji Hyun, Ashktorab, Hassan, Smoot, Duane T, Lee, Dong Ho
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Society of Neurogastroenterology and Motility 30.04.2020
Subjects
Original
Helicobacter pylori
Claudin-2
Dyspepsia
Tight junction proteins
Occludin
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Abstract To determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex. Control (n = 95) and FD (n = 165) groups based on Rome III criteria were prospectively enrolled. Gastric mucosal mRNA expression levels of various TJPs (claudins [CLDN] 1, 2, and 4; zonula occludens-1; occludin [OCLN]) were assessed by reverse transcription polymerase chain reaction. Western blot was performed to determine the levels of various TJPs. infection status was evaluated by histology, rapid urease test, and culture. Questionnaires were analyzed. In all groups irrespective of , FD group showed significantly higher CLDN2 mRNA levels than control group ( = 0.048). The level of CLDN4 mRNA expression was significantly lower in female FD group than in male FD group ( = 0.018). In uninfected subjects, the level of CLDN1 mRNA expression in female FD group was significantly lower than that of male FD group ( = 0.014). The level of CLDN2 mRNA expression was significantly higher in the male postprandial distress syndrome ( = 0.001) and male epigastric pain syndrome ( = 0.023) groups than in the male control group. In Western blot analysis, the expression of OCLN was significantly elevated 48 hour after the culture with strain 43504. can affect a variety of TJPs, particularly claudin-4 and occludin. Claudin-2 is thought to be involved in FD irrespective of status, especially in the pathophysiology of male FD.
AbstractList To determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex.BACKGROUND/AIMSTo determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex.Control (n = 95) and FD (n = 165) groups based on Rome III criteria were prospectively enrolled. Gastric mucosal mRNA expression levels of various TJPs (claudins [CLDN] 1, 2, and 4; zonula occludens-1; occludin [OCLN]) were assessed by reverse transcription polymerase chain reaction. Western blot was performed to determine the levels of various TJPs. Helicobacter pylori infection status was evaluated by histology, rapid urease test, and culture. Questionnaires were analyzed.METHODSControl (n = 95) and FD (n = 165) groups based on Rome III criteria were prospectively enrolled. Gastric mucosal mRNA expression levels of various TJPs (claudins [CLDN] 1, 2, and 4; zonula occludens-1; occludin [OCLN]) were assessed by reverse transcription polymerase chain reaction. Western blot was performed to determine the levels of various TJPs. Helicobacter pylori infection status was evaluated by histology, rapid urease test, and culture. Questionnaires were analyzed.In all groups irrespective of H. pylori , FD group showed significantly higher CLDN2 mRNA levels than control group (P = 0.048). The level of CLDN4 mRNA expression was significantly lower in female FD group than in male FD group (P = 0.018). In H. pylori uninfected subjects, the level of CLDN1 mRNA expression in female FD group was significantly lower than that of male FD group (P = 0.014). The level of CLDN2 mRNA expression was significantly higher in the male postprandial distress syndrome (P = 0.001) and male epigastric pain syndrome (P = 0.023) groups than in the male control group. In Western blot analysis, the expression of OCLN was significantly elevated 48 hour after the culture with H. pylori strain 43504.RESULTSIn all groups irrespective of H. pylori , FD group showed significantly higher CLDN2 mRNA levels than control group (P = 0.048). The level of CLDN4 mRNA expression was significantly lower in female FD group than in male FD group (P = 0.018). In H. pylori uninfected subjects, the level of CLDN1 mRNA expression in female FD group was significantly lower than that of male FD group (P = 0.014). The level of CLDN2 mRNA expression was significantly higher in the male postprandial distress syndrome (P = 0.001) and male epigastric pain syndrome (P = 0.023) groups than in the male control group. In Western blot analysis, the expression of OCLN was significantly elevated 48 hour after the culture with H. pylori strain 43504.H. pylori can affect a variety of TJPs, particularly claudin-4 and occludin. Claudin-2 is thought to be involved in FD irrespective of H. pylori status, especially in the pathophysiology of male FD.CONCLUSIONSH. pylori can affect a variety of TJPs, particularly claudin-4 and occludin. Claudin-2 is thought to be involved in FD irrespective of H. pylori status, especially in the pathophysiology of male FD.
To determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex. Control (n = 95) and FD (n = 165) groups based on Rome III criteria were prospectively enrolled. Gastric mucosal mRNA expression levels of various TJPs (claudins [CLDN] 1, 2, and 4; zonula occludens-1; occludin [OCLN]) were assessed by reverse transcription polymerase chain reaction. Western blot was performed to determine the levels of various TJPs. infection status was evaluated by histology, rapid urease test, and culture. Questionnaires were analyzed. In all groups irrespective of , FD group showed significantly higher CLDN2 mRNA levels than control group ( = 0.048). The level of CLDN4 mRNA expression was significantly lower in female FD group than in male FD group ( = 0.018). In uninfected subjects, the level of CLDN1 mRNA expression in female FD group was significantly lower than that of male FD group ( = 0.014). The level of CLDN2 mRNA expression was significantly higher in the male postprandial distress syndrome ( = 0.001) and male epigastric pain syndrome ( = 0.023) groups than in the male control group. In Western blot analysis, the expression of OCLN was significantly elevated 48 hour after the culture with strain 43504. can affect a variety of TJPs, particularly claudin-4 and occludin. Claudin-2 is thought to be involved in FD irrespective of status, especially in the pathophysiology of male FD.
Author Kim, Nayoung
Smoot, Duane T
Ashktorab, Hassan
Lee, Dong Ho
Choi, Yoon Jin
Park, Ji Hyun
Lee, Ju Yup
AuthorAffiliation 1 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea
5 Department of Medicine, Meharry Medical Center, Nashville, Tennessee, USA
4 Department of Medicine and Cancer Center, Howard University College of Medicine, Washington, District of Columbia, USA
3 Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
2 Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
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Keywords Helicobacter pylori
Claudin-2
Dyspepsia
Tight junction proteins
Occludin
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To determine whether the expression of tight junction proteins (TJPs) differs depending on the subtype of functional dyspepsia (FD) and sex.BACKGROUND/AIMSTo...
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Title Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex
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