SGLT-2 inhibitors and the risk of infections: a systematic review and meta-analysis of randomized controlled trials

• Published in: Acta diabetologica Vol. 55; no. 5; pp. 503 - 514
• Main Authors: Puckrin, Robert, Saltiel, Marie-Philippe, Reynier, Pauline, Azoulay, Laurent, Yu, Oriana H. Y., Filion, Kristian B.
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.05.2018; Springer Nature B.V
• Subjects: Benzhydryl Compounds - adverse effects; Benzhydryl Compounds - therapeutic use; Clinical trials; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - epidemiology; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - etiology; Gastroenteritis; Genital tract; Glucose transporter; Glucosides - adverse effects; Glucosides - therapeutic use; Health risk assessment; Humans; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - therapeutic use; Infections - epidemiology; Infections - etiology; Inhibitor drugs; Internal Medicine; Medicine; Medicine & Public Health; Meta-analysis; Metabolic Diseases; Original Article; Randomized Controlled Trials as Topic - statistics & numerical data; Respiratory tract diseases; Risk Factors; Sodium; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Systematic review; Urinary tract; Urinary tract infections; Sodium–glucose co-transporter 2 (SGLT-2) inhibitors; Infections; Type 2 diabetes mellitus; Adverse events; Systematic review and meta-analysis

Aims There is concern about the infection-related safety profile of sodium–glucose co-transporter 2 (SGLT-2) inhibitors. We aimed to determine the effect of SGLT-2 inhibitors on genitourinary and other infections via systematic review and meta-analysis of randomized controlled trials (RCTs). Methods...