C-reactive protein promotes bone destruction in human myeloma through the CD32-p38 MAPK-Twist axis

• Published in: Science signaling Vol. 10; no. 509
• Main Authors: Yang, Jing, Liu, Zhiqiang, Liu, Huan, He, Jin, Yang, Jianling, Lin, Pei, Wang, Qiang, Du, Juan, Ma, Wencai, Yin, Zheng, Davis, Eric, Orlowski, Robert Z, Hou, Jian, Yi, Qing
• Format: Journal Article
• Language: English
• Published: United States 12.12.2017

Bone destruction is a hallmark of myeloma and affects 80% of patients. Myeloma cells promote bone destruction by activating osteoclasts. In investigating the underlying mechanism, we found that C-reactive protein (CRP), a protein secreted in increased amounts by hepatocytes in response to myeloma-de...