C-reactive protein promotes bone destruction in human myeloma through the CD32-p38 MAPK-Twist axis
Bone destruction is a hallmark of myeloma and affects 80% of patients. Myeloma cells promote bone destruction by activating osteoclasts. In investigating the underlying mechanism, we found that C-reactive protein (CRP), a protein secreted in increased amounts by hepatocytes in response to myeloma-de...
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Published in | Science signaling Vol. 10; no. 509 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
12.12.2017
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Online Access | Get more information |
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