A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

• Published in: Scientific reports Vol. 6; no. 1; p. 37789
• Main Authors: Lund, Maria E., Greer, Judith, Dixit, Aakanksha, Alvarado, Raquel, McCauley-Winter, Padraig, To, Joyce, Tanaka, Akane, Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., O’Brien, Bronwyn A., Dalton, John P., Donnelly, Sheila
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.11.2016; Nature Publishing Group
• Subjects: 13; 13/106; 13/21; 13/31; 631/250/38; 631/326/417/2547; Animal models; Autoimmune diseases; Cell proliferation; Cytokines; Demyelination; Diabetes; Diabetes mellitus; Disease; Humanities and Social Sciences; Immune response; Inflammation; Interleukin 6; Lymphocytes; Lymphocytes T; Macrophages; multidisciplinary; Multiple sclerosis; Parasites; Peptides; Science; T cell receptors; Tumor necrosis factor

Helminth parasites secrete molecules that potently modulate the immune responses of their hosts and, therefore, have potential for the treatment of immune-mediated human diseases. FhHDM-1, a 68-mer peptide secreted by the helminth parasite Fasciola hepatica, ameliorated disease in two different muri...