Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis

• Published in: Scientific reports Vol. 6; no. 1; p. 27453
• Main Authors: Hu, Zihua, Jiang, Kaiyu, Frank, Mark Barton, Chen, Yanmin, Jarvis, James N.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.06.2016; Nature Publishing Group
• Subjects: 38/39; 45; 631/114; 631/250/2504; Arthritis; Bioinformatics; Cluster analysis; Disease; Gene expression; Genomes; Genomics; Humanities and Social Sciences; MicroRNAs; multidisciplinary; Neutrophils; Proteins; Science

NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity in the transcriptomes of mammalian cells. In this study, we explored transcriptional complexity in human neutrophils, cells generally regarded as nonspecific in their functions and responses. We studied distinct...