Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis

NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity in the transcriptomes of mammalian cells. In this study, we explored transcriptional complexity in human neutrophils, cells generally regarded as nonspecific in their functions and responses. We studied distinct...

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Published inScientific reports Vol. 6; no. 1; p. 27453
Main Authors Hu, Zihua, Jiang, Kaiyu, Frank, Mark Barton, Chen, Yanmin, Jarvis, James N.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 07.06.2016
Nature Publishing Group
Subjects
38/39
45
631/114
631/250/2504
Arthritis
Bioinformatics
Cluster analysis
Disease
Gene expression
Genomes
Genomics
Humanities and Social Sciences
MicroRNAs
multidisciplinary
Neutrophils
Proteins
Science
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Abstract NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity in the transcriptomes of mammalian cells. In this study, we explored transcriptional complexity in human neutrophils, cells generally regarded as nonspecific in their functions and responses. We studied distinct human disease phenotypes and found that, at the gene, gene isoform, and miRNA level, neutrophils exhibit considerable specificity in their transcriptomes. Thus, even cells whose responses are considered non-specific show tailoring of their transcriptional repertoire toward specific physiologic or pathologic contexts. We also found that miRNAs had a global impact on neutrophil transcriptome and are associated with innate immunity in juvenile idiopathic arthritis (JIA). These findings have important implications for our understanding of the link between genes, non-coding transcripts and disease phenotypes.
AbstractList NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity in the transcriptomes of mammalian cells. In this study, we explored transcriptional complexity in human neutrophils, cells generally regarded as nonspecific in their functions and responses. We studied distinct human disease phenotypes and found that, at the gene, gene isoform, and miRNA level, neutrophils exhibit considerable specificity in their transcriptomes. Thus, even cells whose responses are considered non-specific show tailoring of their transcriptional repertoire toward specific physiologic or pathologic contexts. We also found that miRNAs had a global impact on neutrophil transcriptome and are associated with innate immunity in juvenile idiopathic arthritis (JIA). These findings have important implications for our understanding of the link between genes, non-coding transcripts and disease phenotypes.
ArticleNumber 27453
Author Jarvis, James N.
Chen, Yanmin
Frank, Mark Barton
Jiang, Kaiyu
Hu, Zihua
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  givenname: Zihua
  surname: Hu
  fullname: Hu, Zihua
  organization: Center for Computational Research, New York State Center of Excellence in Bioinformatics & Life Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA. , Department of Ophthalmology, Department of Biostatistics, Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14260, USA, SUNY Eye Institute
– sequence: 2
  givenname: Kaiyu
  surname: Jiang
  fullname: Jiang, Kaiyu
  organization: Department of Pediatrics, Division of Allergy/Immunology/Rheumatology, University at Buffalo
– sequence: 3
  givenname: Mark Barton
  surname: Frank
  fullname: Frank, Mark Barton
  organization: Arthritis & Immunology Program, Oklahoma Medical Research Foundation
– sequence: 4
  givenname: Yanmin
  surname: Chen
  fullname: Chen, Yanmin
  organization: Department of Pediatrics, Division of Allergy/Immunology/Rheumatology, University at Buffalo
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  givenname: James N.
  surname: Jarvis
  fullname: Jarvis, James N.
  email: jamesjar@buffalo.edu
  organization: Department of Pediatrics, Division of Allergy/Immunology/Rheumatology, University at Buffalo, Graduate Program in Genetics, Genomics, & Bioinformatics, University at Buffalo
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Copyright The Author(s) 2016
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Snippet NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity in the transcriptomes of mammalian cells. In this study, we explored...
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SubjectTerms 38/39
45
631/114
631/250/2504
Arthritis
Bioinformatics
Cluster analysis
Disease
Gene expression
Genomes
Genomics
Humanities and Social Sciences
MicroRNAs
multidisciplinary
Neutrophils
Proteins
Science
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Title Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis
URI https://link.springer.com/article/10.1038/srep27453
https://www.ncbi.nlm.nih.gov/pubmed/27271962
https://www.proquest.com/docview/1794907286
https://search.proquest.com/docview/1795877581
https://pubmed.ncbi.nlm.nih.gov/PMC4895221
Volume 6
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