QuEChERS Extraction and Simultaneous Quantification in GC-MS/MS of Hexahydrocannabinol Epimers and Their Metabolites in Whole Blood, Urine, and Oral Fluid

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 14; p. 3440
• Main Authors: Di Trana, Annagiulia, Sprega, Giorgia, Kobidze, Giorgi, Taoussi, Omayema, Lo Faro, Alfredo Fabrizio, Bambagiotti, Giulia, Montanari, Eva, Fede, Maria Sofia, Carlier, Jeremy, Tini, Anastasio, Busardò, Francesco Paolo, Di Giorgi, Alessandro, Pichini, Simona
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.07.2024
• Subjects: cannabinoids; Chromatography; GC-MS/MS; hexahydrocannabinol epimers; hexahydrocannabinol metabolites; Laboratories; Marijuana; Metabolism; Metabolites; Methods; new psychoactive substances; Psychotropic drugs; QuEChERS; Tetrahydrocannabinol; THC; Urine; United States > US; cannabinoids; hexahydrocannabinol epimers; GC-MS/MS; new psychoactive substances; QuEChERS; hexahydrocannabinol metabolites

Recently, hexahydrocannabinol (HHC) was posed under strict control in Europe due to the increasing HHC-containing material seizures. The lack of analytical methods in clinical laboratories to detect HHC and its metabolites in biological matrices may result in related intoxication underreporting. We...