Antihypertensive Drugs, Prevention of Cognitive Decline and Dementia: A Systematic Review of Observational Studies, Randomized Controlled Trials and Meta-Analyses, with Discussion of Potential Mechanisms

• Published in: CNS drugs Vol. 29; no. 2; pp. 113 - 130
• Main Authors: Rouch, Laure, Cestac, Philippe, Hanon, Olivier, Cool, Charlène, Helmer, Catherine, Bouhanick, Béatrice, Chamontin, Bernard, Dartigues, Jean-Franҫois, Vellas, Bruno, Andrieu, Sandrine
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2015; Springer Nature B.V
• Subjects: Antihypertensive Agents - therapeutic use; Cognition Disorders - prevention & control; Dementia; Dementia - prevention & control; Humans; Medicine; Medicine & Public Health; Meta-Analysis as Topic; Neurology; Neurosciences; Nootropic Agents - therapeutic use; Observational Studies as Topic; Pharmacotherapy; Psychiatry; Psychopharmacology; Randomized Controlled Trials as Topic; Systematic Review; Cognitive Decline; Ramipril; Mini Mental State Examination; Candesartan; Dementia

Background Chronic hypertension, particularly midlife high blood pressure, has been associated with an increased risk for cognitive decline and dementia. In this context, antihypertensive drugs might have a preventive effect, but the association remains poorly understood. Objectives The aim of this...