In vitro antibacterial effects of statins against bacterial pathogens causing skin infections

• Published in: European journal of clinical microbiology & infectious diseases Vol. 37; no. 6; pp. 1125 - 1135
• Main Authors: Ko, Humphrey H. T., Lareu, Ricky R., Dix, Brett R., Hughes, Jeffery D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2018; Springer Nature B.V
• Subjects: Alanine; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents, Local - pharmacology; Antibacterial activity; Antibiotics; Bacteria; Biofilms; Biomedical and Life Sciences; Biomedicine; Cell division; Cholesterol; Drug development; Drug Discovery; Drug Repositioning; E coli; Escherichia coli - drug effects; Escherichia coli - pathogenicity; Failure analysis; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Internal Medicine; Medical Microbiology; Metabolites; Microbial Sensitivity Tests; Original Article; Pathogens; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - pathogenicity; R&D; Research & development; Simvastatin; Simvastatin - analogs & derivatives; Simvastatin - pharmacology; Skin; Skin - microbiology; Skin tests; Staphylococcal Skin Infections - drug therapy; Staphylococcal Skin Infections - microbiology; Staphylococcus aureus - drug effects; Staphylococcus aureus - pathogenicity; Statins; Drug repurposing; Skin infections; Mechanism of action; Topical antibiotics; Statins; Paradoxical growth effect

With financial considerations impeding research and development of new antibiotics, drug repurposing (finding new indications for old drugs) emerges as a feasible alternative. Statins are extensively prescribed around the world to lower cholesterol, but they also possess inherent antimicrobial prope...