Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a

• Published in: Scientific reports Vol. 6; no. 1; p. 21865
• Main Authors: Wang, Guo-qiang, Wang, Yu, Xiong, Yan, Chen, Xiao-Chang, Ma, Mei-ling, Cai, Rui, Gao, Yun, Sun, Yun-mei, Yang, Gong-She, Pang, Wei-Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.02.2016; Nature Publishing Group
• Subjects: 13/109; 13/31; 13/44; 3' Untranslated regions; 38/39; 38/77; 631/337/384; 631/80/83; 64/60; 82/80; Animals; Antisense RNA; Base Sequence; Body fat; Body Weight; Cell Differentiation; Cell Line; Cell Proliferation; Cytoplasm; Gene expression; Gene Expression Regulation, Developmental; Genes, Reporter; Humanities and Social Sciences; Luciferases - genetics; Luciferases - metabolism; Mice; Mice, Inbred C57BL; MicroRNAs - genetics; MicroRNAs - metabolism; mRNA stability; multidisciplinary; Muscle Development - genetics; Myoblasts - cytology; Myoblasts - metabolism; Myogenesis; Nucleic Acid Conformation; Protein Biosynthesis; Ribonuclease; RNA Stability; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Science; Signal Transduction; SIRT1 protein; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Transcription; Transcription, Genetic

Recent studies demonstrate the functions of long non-coding RNAs (lncRNAs) in mediating gene expression at the transcriptional or translational level. Our previous study identified a Sirt1 antisense (AS) lncRNA transcribed from the Sirt1 AS strand. However, its role and regulatory mechanism is still...