Index of glucose effectiveness derived from oral glucose tolerance test

Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI O was developed in the Chikuma cohort ( n  = 502). Firstly, post-loading plasma glucose without insulin action and Sg (...

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Published inActa diabetologica Vol. 49; no. Suppl 1; pp. 195 - 204
Main Authors Nagasaka, Shoichiro, Kusaka, Ikuyo, Yamashita, Koh, Funase, Yoshiko, Yamauchi, Keishi, Katakura, Masafumi, Ishibashi, Shun, Aizawa, Toru
Format Journal Article
LanguageEnglish
Published Milan Springer Milan 01.12.2012
Springer Nature B.V
Subjects
Adult
Aged
Cohort Studies
Diabetes
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - metabolism
Diagnostic tests
Effectiveness studies
Female
Glucose
Glucose - metabolism
Glucose Tolerance Test - methods
Glucose Tolerance Test - standards
Humans
Insulin
Insulin - metabolism
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
Insulin
Glucose effectiveness
Diabetes
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Abstract Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI O was developed in the Chikuma cohort ( n  = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin and Sg) was calculated as follows: fasting plasma glucose (mg/dl) + [0.75 × 75,000]/[0.19 × BW(kg) × 10]. Secondly, ‘PPG-without insulin/with Sg’ was obtained from inverse correlation between log 10 DI O and 2-h post-glucose plasma glucose at OGTT (2hPG) in each glucose tolerance category: DI O denotes oral disposition index, a product of the Matsuda Index and δIRI 0–30 /δPG 0–30 . Thirdly, expected 2hPG (2hPG E ) of a given subject was obtained from the regression, and the ratio of 2hPG to 2hPG E (2hPG/2hPG E ) was determined as an adjustment factor. Lastly, SgI O ([mg/dl]/min) was calculated as . SgI O was validated against Sg obtained by frequently sampled intravenous glucose tolerance test in the Jichi cohort ( n  = 205). Also, the accuracy of prediction of Sg by SgIo was tested by the Bland–Altman plot. SgI O was 3.61 ± 0.73, 3.17 ± 0.74 and 2.15 ± 0.60 in subjects with normal glucose tolerance (NGT), non-diabetic hyperglycemia and diabetes, respectively, in the Chikuma cohort. In the Jichi cohort, SgI O was significantly correlated with Sg in the entire group ( r  = 0.322, P  < 0.001) and in subjects with NGT ( r  = 0.286, P  < 0.001), and SgIo accurately predicted Sg. In conclusion, SgI O could be a simple, quantitative index for Sg.
AbstractList (ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image) Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI^sub O^ was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin and Sg) was calculated as follows: fasting plasma glucose (mg/dl) + [0.75 × 75,000]/[0.19 × BW(kg) × 10]. Secondly, 'PPG-without insulin/with Sg' was obtained from inverse correlation between log^sub 10^DI^sub O^ and 2-h post-glucose plasma glucose at OGTT (2hPG) in each glucose tolerance category: DI^sub O^ denotes oral disposition index, a product of the Matsuda Index and δIRI^sub 0-30^/δPG^sub 0-30^. Thirdly, expected 2hPG (2hPG^sub E^) of a given subject was obtained from the regression, and the ratio of 2hPG to 2hPG^sub E^ (2hPG/2hPG^sub E^) was determined as an adjustment factor. Lastly, SgI^sub O^ ([mg/dl]/min) was calculated as ... SgI^sub O^ was validated against Sg obtained by frequently sampled intravenous glucose tolerance test in the Jichi cohort (n = 205). Also, the accuracy of prediction of Sg by SgIo was tested by the Bland-Altman plot. SgI^sub O^ was 3.61 ± 0.73, 3.17 ± 0.74 and 2.15 ± 0.60 in subjects with normal glucose tolerance (NGT), non-diabetic hyperglycemia and diabetes, respectively, in the Chikuma cohort. In the Jichi cohort, SgI^sub O^ was significantly correlated with Sg in the entire group (r = 0.322, P < 0.001) and in subjects with NGT (r = 0.286, P < 0.001), and SgIo accurately predicted Sg. In conclusion, SgI^sub O^ could be a simple, quantitative index for Sg.[PUBLICATION ABSTRACT]
Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin and Sg) was calculated as follows: fasting plasma glucose (mg/dl) + [0.75 × 75,000]/[0.19 × BW(kg) × 10]. Secondly, 'PPG-without insulin/with Sg' was obtained from inverse correlation between log(10)DI(O) and 2-h post-glucose plasma glucose at OGTT (2hPG) in each glucose tolerance category: DI(O) denotes oral disposition index, a product of the Matsuda Index and δIRI(0-30)/δPG(0-30). Thirdly, expected 2hPG (2hPG(E)) of a given subject was obtained from the regression, and the ratio of 2hPG to 2hPG(E) (2hPG/2hPG(E)) was determined as an adjustment factor. Lastly, SgI(O) ([mg/dl]/min) was calculated as [PPG-without insulin and Sg]-[PPG-without insulin / with Sg] x [(2hPG) / 2hPG(E)]. SgI(O) was validated against Sg obtained by frequently sampled intravenous glucose tolerance test in the Jichi cohort (n = 205). Also, the accuracy of prediction of Sg by SgIo was tested by the Bland-Altman plot. SgI(O) was 3.61 ± 0.73, 3.17 ± 0.74 and 2.15 ± 0.60 in subjects with normal glucose tolerance (NGT), non-diabetic hyperglycemia and diabetes, respectively, in the Chikuma cohort. In the Jichi cohort, SgI(O) was significantly correlated with Sg in the entire group (r = 0.322, P < 0.001) and in subjects with NGT (r = 0.286, P < 0.001), and SgIo accurately predicted Sg. In conclusion, SgI(O) could be a simple, quantitative index for Sg.
Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin and Sg) was calculated as follows: fasting plasma glucose (mg/dl) + [0.75 × 75,000]/[0.19 × BW(kg) × 10]. Secondly, 'PPG-without insulin/with Sg' was obtained from inverse correlation between log(10)DI(O) and 2-h post-glucose plasma glucose at OGTT (2hPG) in each glucose tolerance category: DI(O) denotes oral disposition index, a product of the Matsuda Index and δIRI(0-30)/δPG(0-30). Thirdly, expected 2hPG (2hPG(E)) of a given subject was obtained from the regression, and the ratio of 2hPG to 2hPG(E) (2hPG/2hPG(E)) was determined as an adjustment factor. Lastly, SgI(O) ([mg/dl]/min) was calculated as [PPG-without insulin and Sg]-[PPG-without insulin / with Sg] x [(2hPG) / 2hPG(E)]. SgI(O) was validated against Sg obtained by frequently sampled intravenous glucose tolerance test in the Jichi cohort (n = 205). Also, the accuracy of prediction of Sg by SgIo was tested by the Bland-Altman plot. SgI(O) was 3.61 ± 0.73, 3.17 ± 0.74 and 2.15 ± 0.60 in subjects with normal glucose tolerance (NGT), non-diabetic hyperglycemia and diabetes, respectively, in the Chikuma cohort. In the Jichi cohort, SgI(O) was significantly correlated with Sg in the entire group (r = 0.322, P < 0.001) and in subjects with NGT (r = 0.286, P < 0.001), and SgIo accurately predicted Sg. In conclusion, SgI(O) could be a simple, quantitative index for Sg.Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin and Sg) was calculated as follows: fasting plasma glucose (mg/dl) + [0.75 × 75,000]/[0.19 × BW(kg) × 10]. Secondly, 'PPG-without insulin/with Sg' was obtained from inverse correlation between log(10)DI(O) and 2-h post-glucose plasma glucose at OGTT (2hPG) in each glucose tolerance category: DI(O) denotes oral disposition index, a product of the Matsuda Index and δIRI(0-30)/δPG(0-30). Thirdly, expected 2hPG (2hPG(E)) of a given subject was obtained from the regression, and the ratio of 2hPG to 2hPG(E) (2hPG/2hPG(E)) was determined as an adjustment factor. Lastly, SgI(O) ([mg/dl]/min) was calculated as [PPG-without insulin and Sg]-[PPG-without insulin / with Sg] x [(2hPG) / 2hPG(E)]. SgI(O) was validated against Sg obtained by frequently sampled intravenous glucose tolerance test in the Jichi cohort (n = 205). Also, the accuracy of prediction of Sg by SgIo was tested by the Bland-Altman plot. SgI(O) was 3.61 ± 0.73, 3.17 ± 0.74 and 2.15 ± 0.60 in subjects with normal glucose tolerance (NGT), non-diabetic hyperglycemia and diabetes, respectively, in the Chikuma cohort. In the Jichi cohort, SgI(O) was significantly correlated with Sg in the entire group (r = 0.322, P < 0.001) and in subjects with NGT (r = 0.286, P < 0.001), and SgIo accurately predicted Sg. In conclusion, SgI(O) could be a simple, quantitative index for Sg.
Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI O was developed in the Chikuma cohort ( n  = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin and Sg) was calculated as follows: fasting plasma glucose (mg/dl) + [0.75 × 75,000]/[0.19 × BW(kg) × 10]. Secondly, ‘PPG-without insulin/with Sg’ was obtained from inverse correlation between log 10 DI O and 2-h post-glucose plasma glucose at OGTT (2hPG) in each glucose tolerance category: DI O denotes oral disposition index, a product of the Matsuda Index and δIRI 0–30 /δPG 0–30 . Thirdly, expected 2hPG (2hPG E ) of a given subject was obtained from the regression, and the ratio of 2hPG to 2hPG E (2hPG/2hPG E ) was determined as an adjustment factor. Lastly, SgI O ([mg/dl]/min) was calculated as . SgI O was validated against Sg obtained by frequently sampled intravenous glucose tolerance test in the Jichi cohort ( n  = 205). Also, the accuracy of prediction of Sg by SgIo was tested by the Bland–Altman plot. SgI O was 3.61 ± 0.73, 3.17 ± 0.74 and 2.15 ± 0.60 in subjects with normal glucose tolerance (NGT), non-diabetic hyperglycemia and diabetes, respectively, in the Chikuma cohort. In the Jichi cohort, SgI O was significantly correlated with Sg in the entire group ( r  = 0.322, P  < 0.001) and in subjects with NGT ( r  = 0.286, P  < 0.001), and SgIo accurately predicted Sg. In conclusion, SgI O could be a simple, quantitative index for Sg.
Author Kusaka, Ikuyo
Aizawa, Toru
Yamauchi, Keishi
Katakura, Masafumi
Nagasaka, Shoichiro
Funase, Yoshiko
Ishibashi, Shun
Yamashita, Koh
Author_xml – sequence: 1
  givenname: Shoichiro
  surname: Nagasaka
  fullname: Nagasaka, Shoichiro
  organization: Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University
– sequence: 2
  givenname: Ikuyo
  surname: Kusaka
  fullname: Kusaka, Ikuyo
  organization: Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University
– sequence: 3
  givenname: Koh
  surname: Yamashita
  fullname: Yamashita, Koh
  organization: Aizawa Hospital Diabetes Center
– sequence: 4
  givenname: Yoshiko
  surname: Funase
  fullname: Funase, Yoshiko
  organization: Aizawa Hospital Diabetes Center
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  givenname: Keishi
  surname: Yamauchi
  fullname: Yamauchi, Keishi
  organization: Aizawa Hospital Diabetes Center
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  givenname: Masafumi
  surname: Katakura
  fullname: Katakura, Masafumi
  organization: Department of Medicine, Chikuma Central Hospital
– sequence: 7
  givenname: Shun
  surname: Ishibashi
  fullname: Ishibashi, Shun
  organization: Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University
– sequence: 8
  givenname: Toru
  surname: Aizawa
  fullname: Aizawa, Toru
  email: taizawax@ai-hosp.or.jp
  organization: Aizawa Hospital Diabetes Center
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22836490$$D View this record in MEDLINE/PubMed
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Issue Suppl 1
Keywords Insulin
Glucose effectiveness
Diabetes
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PublicationTitle Acta diabetologica
PublicationTitleAbbrev Acta Diabetol
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Snippet Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT)....
Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT)....
(ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image) Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo,...
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SubjectTerms Adult
Aged
Cohort Studies
Diabetes
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - metabolism
Diagnostic tests
Effectiveness studies
Female
Glucose
Glucose - metabolism
Glucose Tolerance Test - methods
Glucose Tolerance Test - standards
Humans
Insulin
Insulin - metabolism
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
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Title Index of glucose effectiveness derived from oral glucose tolerance test
URI https://link.springer.com/article/10.1007/s00592-012-0417-y
https://www.ncbi.nlm.nih.gov/pubmed/22836490
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