Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients

• Published in: Scientific reports Vol. 6; no. 1; p. 32027
• Main Authors: Liu, Ning Qing, De Marchi, Tommaso, Timmermans, Annemieke, Trapman-Jansen, Anita M. A. C., Foekens, Renée, Look, Maxime P., Smid, Marcel, van Deurzen, Carolien H. M., Span, Paul N., Sweep, Fred C. G. J., Brask, Julie Benedicte, Timmermans-Wielenga, Vera, Foekens, John A., Martens, John W. M., Umar, Arzu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.08.2016; Nature Publishing Group
• Subjects: 14/105; 45; 45/61; 692/4028/67/1347; 692/53/2422; 82; 82/58; Adult; Aged; Breast cancer; Cell cycle; Cell Nucleus - enzymology; Correlation analysis; Databases, Factual; Extracellular matrix; Extracellular Matrix - genetics; Female; Gene expression; Gene Expression Regulation, Neoplastic; Gene set enrichment analysis; Humanities and Social Sciences; Humans; Immunohistochemistry; Kinases; Mass spectroscopy; Medical prognosis; Metastases; Middle Aged; multidisciplinary; Nucleoside-Phosphate Kinase - genetics; Nucleoside-Phosphate Kinase - metabolism; Paraffin; Prognosis; Science; Tissue Array Analysis; Triple Negative Breast Neoplasms - enzymology; Triple Negative Breast Neoplasms - mortality; Triple Negative Breast Neoplasms - pathology; Triple Negative Breast Neoplasms - therapy

We have previously identified UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer (TNBC) by mass spectrometry (MS). In this study we evaluated CMPK1 association to prognosis in an independent set of samples by immunohistochemistry (IHC) and assessed biological pathways as...