Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes

• Published in: Journal of bioenergetics and biomembranes Vol. 49; no. 5; pp. 399 - 411
• Main Authors: Dechandt, Carlos R. P., Zuccolotto-dos-Reis, Felippe H., Teodoro, Bruno G., Fernandes, Anna Maria A. P., Eberlin, Marcos N., Kettelhut, Isis C., Curti, Carlos, Alberici, Luciane C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2017; Springer Nature B.V
• Subjects: Animal Anatomy; Animal Biochemistry; Animals; Apoptosis; Biochemistry; Bioorganic Chemistry; Biosynthesis; Carbonyl compounds; Carbonyls; Cells, Cultured; Chemistry; Chemistry and Materials Science; Dose-Response Relationship, Drug; Electron transport; Electron transport chain; Esterification; Fatty acids; Fatty liver; Hepatocytes; Hepatocytes - cytology; Histology; Lipid Droplets - drug effects; Lipid metabolism; Lipid Metabolism - drug effects; Lipid peroxidation; Lipids; Liver; Liver diseases; Membrane permeability; Metabolism; Mitochondria; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Mitochondrial permeability transition pore; Morphology; Non-alcoholic Fatty Liver Disease - drug therapy; Organelle Biogenesis; Organic Chemistry; Oxidation; Pathogenesis; Rats; Reactive oxygen species; Rodents; TOR protein; Transcription; Triazenes - pharmacology; Triazenes - therapeutic use; Primary hepatocyte; Mitochondria; Reactive oxygen species; Biogenesis; Acyl-CoA synthetase; Triacsin C

Intracellular long-chain acyl-CoA synthetases (ACSL) activate fatty acids to produce acyl-CoA, which undergoes β-oxidation and participates in the synthesis of esterified lipids such as triacylglycerol (TAG). Imbalances in these metabolic routes are closely associated with the pathogenesis of non-al...