Primary, self-renewing erythroid progenitors develop through activation of both tyrosine kinase and steroid hormone receptors

• Published in: Current biology Vol. 5; no. 2; pp. 191 - 204
• Main Authors: Steinlein, Peter, Wessely, Oliver, Meyer, Susanne, Deiner, Eva-Maria, Hayman, Michael J., Beug, Hartmut
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.02.1995
• Subjects: Animals; Cells, Cultured; Chickens; Clone Cells; Enzyme Activation; ErbB Receptors - metabolism; Erythroid Precursor Cells - cytology; Erythroid Precursor Cells - metabolism; Estradiol - metabolism; Hematopoiesis; Hematopoietic Cell Growth Factors - metabolism; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases - metabolism; Receptors, Colony-Stimulating Factor - metabolism; Receptors, Steroid - metabolism; Stem Cell Factor; Transforming Growth Factor alpha - metabolism

Background: Self renewal in the hematopoietic system is thought to be restricted to a class of pluripotent stem cells. The capacity of cells with the properties of committed progenitors to self renew in many leukemias is thought to be an abnormal property resulting from the mutations responsible for...