Brain Network Informed Subject Community Detection In Early-Onset Schizophrenia

• Published in: Scientific reports Vol. 4; no. 1; p. 5549
• Main Authors: Yang, Zhi, Xu, Yong, Xu, Ting, Hoy, Colin W., Handwerker, Daniel A., Chen, Gang, Northoff, Georg, Zuo, Xi-Nian, Bandettini, Peter A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.07.2014; Nature Publishing Group
• Subjects: 59/36; 631/378/1689/1799; 631/378/2650; Adolescent; Brain Mapping; Case-Control Studies; Child; Classification; Emotional behavior; Female; Frontal Lobe - physiopathology; Humanities and Social Sciences; Humans; Male; Mental disorders; multidisciplinary; Multivariate Analysis; Nerve Net - physiopathology; Neural networks; Reproducibility of Results; Schizophrenia; Schizophrenia, Childhood - diagnosis; Schizophrenia, Childhood - physiopathology; Science; Temporal Lobe - physiopathology

Early-onset schizophrenia (EOS) offers a unique opportunity to study pathophysiological mechanisms and development of schizophrenia. Using 26 drug-naïve, first-episode EOS patients and 25 age- and gender-matched control subjects, we examined intrinsic connectivity network (ICN) deficits underlying E...