The intestinal epithelium: sensors to effectors in nematode infection

The role of the intestinal epithelium as part of the physical barrier to infection is well established alongside its central roles in food absorption, sensing nutrients, and water balance. Nematodes are one of the most common types of pathogen to dwell in the intestine. This article reviews recent d...

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Published inMucosal immunology Vol. 1; no. 4; pp. 252 - 264
Main Authors Artis, D, Grencis, R K
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.07.2008
Subjects
Animals
Cell Line
Chemokines - immunology
Epithelial Cells - immunology
Epithelial Cells - parasitology
Goblet Cells - immunology
Humans
Immunity, Innate
Intestinal Mucosa - immunology
Intestinal Mucosa - parasitology
Macrophages - immunology
Mast Cells - immunology
Nematode Infections - immunology
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Abstract The role of the intestinal epithelium as part of the physical barrier to infection is well established alongside its central roles in food absorption, sensing nutrients, and water balance. Nematodes are one of the most common types of pathogen to dwell in the intestine. This article reviews recent data that have identified crucial roles for intestinal epithelial cells in sensing these kinds of pathogens and initiating innate responses, which qualitatively influence adaptive immune responses against them. Moreover, it is now clear that the epithelium itself--in addition to the cells that lie within it--are key to many of the protective mechanisms that result in expulsion of these large multicellular parasites from the intestine. An understanding of the IEC and intraepithelial leukocyte response is crucial to both development of mucosal vaccines, and the mechanisms that underlie the emerging use of intestinal dwelling helminths for therapeutic treatments of inflammatory and autoimmune disease.
AbstractList The role of the intestinal epithelium as part of the physical barrier to infection is well established alongside its central roles in food absorption, sensing nutrients, and water balance. Nematodes are one of the most common types of pathogen to dwell in the intestine. This article reviews recent data that have identified crucial roles for intestinal epithelial cells in sensing these kinds of pathogens and initiating innate responses, which qualitatively influence adaptive immune responses against them. Moreover, it is now clear that the epithelium itself--in addition to the cells that lie within it--are key to many of the protective mechanisms that result in expulsion of these large multicellular parasites from the intestine. An understanding of the IEC and intraepithelial leukocyte response is crucial to both development of mucosal vaccines, and the mechanisms that underlie the emerging use of intestinal dwelling helminths for therapeutic treatments of inflammatory and autoimmune disease.
Author Grencis, R K
Artis, D
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Snippet The role of the intestinal epithelium as part of the physical barrier to infection is well established alongside its central roles in food absorption, sensing...
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pubmed
nature
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StartPage 252
SubjectTerms Animals
Cell Line
Chemokines - immunology
Epithelial Cells - immunology
Epithelial Cells - parasitology
Goblet Cells - immunology
Humans
Immunity, Innate
Intestinal Mucosa - immunology
Intestinal Mucosa - parasitology
Macrophages - immunology
Mast Cells - immunology
Nematode Infections - immunology
Title The intestinal epithelium: sensors to effectors in nematode infection
URI http://dx.doi.org/10.1038/mi.2008.21
https://www.ncbi.nlm.nih.gov/pubmed/19079187
https://www.proquest.com/docview/1782984633/abstract/
https://search.proquest.com/docview/69892982
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