Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus

• Published in: Journal of Nuclear Medicine Vol. 59; no. 7; pp. 1125 - 1132
• Main Authors: Narayan, Nehal, Owen, David R., Mandhair, Harpreet, Smyth, Erica, Carlucci, Francesco, Saleem, Azeem, Gunn, Roger N., Rabiner, Eugenii A., Wells, Lisa, Dakin, Stephanie G., Sabokbar, Afsie, Taylor, Peter C.
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.07.2018
• Subjects: Adult; Arthritis; Arthritis, Rheumatoid - diagnostic imaging; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - metabolism; Arthritis, Rheumatoid - pathology; Autoradiography; Binding; Biomarkers - metabolism; CD4 antigen; Cell activation; Clinical trials; Female; Gene expression; Gene Expression Regulation; Genetics; Humans; Imaging; Immunofluorescence; In vivo methods and tests; Inflammation; Joint diseases; Knee; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - metabolism; Male; Middle Aged; Monocytes; Patients; Phenotype; Positron emission; Positron-Emission Tomography; Proteins; Radioisotopes; Receptors, GABA - metabolism; Rheumatoid arthritis; Rheumatology; Ribonucleic acid; RNA; Stromal Cells - metabolism; Synovial Membrane - metabolism; Synoviocytes; Synovium; Tomography; fibroblast-like synoviocytes; macrophages; translocator protein; positron emission tomography
• ISSN: 0161-5505; 1535-5667; 2159-662X; 1535-5667
• DOI: 10.2967/jnumed.117.202200

PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of TSPO on activated macrophages, TSPO PET has been widely reported in several studies of RA as a means of imaging...