Improved Prediction of Imminent Progression to Clinically Significant Memory Decline Using Surface Multivariate Morphometry Statistics and Sparse Coding

• Published in: Journal of Alzheimer's disease Vol. 81; no. 1; p. 209
• Main Authors: Stonnington, Cynthia M, Wu, Jianfeng, Zhang, Jie, Shi, Jie, Bauer Iii, Robert J, Devadas, Vivek, Su, Yi, Locke, Dona E C, Reiman, Eric M, Caselli, Richard J, Chen, Kewei, Wang, Yalin
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2021
• Subjects: Aged; Aged, 80 and over; Algorithms; Alzheimer Disease - diagnostic imaging; Cognitive Dysfunction - diagnostic imaging; Disease Progression; Female; Hippocampus - diagnostic imaging; Humans; Machine Learning; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging - methods; Positron-Emission Tomography; Prognosis; Prospective Studies; Sensitivity and Specificity; prediction; magnetic resonance imaging; mild cognitive impairment; Alzheimer’s disease; prognosis

Besides their other roles, brain imaging and other biomarkers of Alzheimer's disease (AD) have the potential to inform a cognitively unimpaired (CU) person's likelihood of progression to mild cognitive impairment (MCI) and benefit subject selection when evaluating promising prevention ther...