Prenatal and Postnatal Expression of Glutathione Transferase ζ 1 in Human Liver and the Roles of Haplotype and Subject Age in Determining Activity with Dichloroacetate

• Published in: Drug metabolism and disposition Vol. 40; no. 2; pp. 232 - 239
• Main Authors: Li, Wenjun, Gu, Yuan, James, Margaret O., Hines, Ronald N., Simpson, Pippa, Langaee, Taimour, Stacpoole, Peter W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2012; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: Adult; Age Factors; Aged; Amino Acid Substitution; Antineoplastic Agents - metabolism; Child; Cytoplasm - enzymology; Dichloroacetic Acid - metabolism; Drugs, Investigational - metabolism; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glutathione Transferase - genetics; Glutathione Transferase - metabolism; Halogenation; Humans; Liver - embryology; Liver - enzymology; Liver - growth & development; Male; Middle Aged; Mitochondria, Liver - enzymology; Polymorphism, Single Nucleotide; Substrate Specificity; Young Adult; GSTZ1; DCA; SNP; MAAI; LOQ

Glutathione transferase ζ 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several α-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors. Ag...