Prognostic Impact of HOTAIR Expression is Restricted to ER-Negative Breast Cancers

• Published in: Scientific reports Vol. 5; no. 1; p. 8765
• Main Authors: Gökmen-Polar, Yesim, Vladislav, I. Tudor, Neelamraju, Yaseswini, Janga, Sarath C., Badve, Sunil
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.03.2015; Nature Publishing Group
• Subjects: 38/32; 38/39; 49/61; 692/53/2422; 692/699/67/1347; Antisense RNA; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - mortality; Carcinoma; Cohort Studies; Colon cancer; Colorectal cancer; Datasets as Topic; DNA microarrays; Female; Gene Expression; Genomes; Humanities and Social Sciences; Humans; Kaplan-Meier Estimate; Liver; Liver cancer; Lymphatic Metastasis; Metastases; Metastasis; multidisciplinary; Neoplasm Grading; Prognosis; Receptor, ErbB-2 - metabolism; Receptors, Estrogen - deficiency; Receptors, Estrogen - metabolism; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Science; Transcription; Tumor Burden; Tumors

Expression of HOX transcript antisense intergenic RNA ( HOTAIR ), a large intergenic noncoding RNA (lincRNA), has been described as a metastases-associated lincRNA in various cancers including breast, liver and colon cancer cancers. We sought to determine if expression of HOTAIR could be used as a s...