Pit-1w may regulate prolactin gene expression in mouse testis

Highlights ► Pit-1w and PRL mRNAs are associated with germ cell differentiation in mice testes. ► Pit-1w and PRL mRNAs fade with differentiating germ cell loss in cryptorchid mice. ► Pit-1w specifically transactivates the PRL promoter in mice.

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Bibliographic Details
Published inGeneral and comparative endocrinology Vol. 178; no. 2; pp. 180 - 184
Main Authors Maeda, Kazuki, Taniuchi, Shusuke, Takahashi, Sumio, Takeuchi, Sakae
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2012
Subjects
adults
alternative splicing
Animals
Cell Differentiation - genetics
Cell Differentiation - physiology
Cell Line
Endocrinology & Metabolism
gene expression
Germ Cells - cytology
Germ Cells - metabolism
Humans
luciferase
Male
messenger RNA
Mice
Mice, Inbred ICR
Mouse
Pit-1
pituitary gland
Pituitary Gland - metabolism
prolactin
Prolactin - genetics
Promoter Regions, Genetic - genetics
reporter genes
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
somatotropin
spermatids
spermatocytes
testes
Testicular development
Testis - cytology
Testis - metabolism
thyrotropin
Thyrotropin, beta Subunit - genetics
Transcription Factor Pit-1 - genetics
transcription factors
transcriptional activation
Variant
Variant
Testicular development
Mouse
Pit-1
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Summary:Highlights ► Pit-1w and PRL mRNAs are associated with germ cell differentiation in mice testes. ► Pit-1w and PRL mRNAs fade with differentiating germ cell loss in cryptorchid mice. ► Pit-1w specifically transactivates the PRL promoter in mice.
Bibliography:http://dx.doi.org/10.1016/j.ygcen.2012.05.004
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2012.05.004