Establishing Equivalent Aerobic Exercise Parameters Between Early-Stage Parkinson’s Disease and Pink1 Knockout Rats

• Published in: Journal of Parkinson's disease Vol. 12; no. 6; pp. 1897 - 1915
• Main Authors: Salvatore, Michael F., Soto, Isabel, Kasanga, Ella A., James, Rachael, Shifflet, Marla K., Doshier, Kirby, Little, Joel T., John, Joshia, Alphonso, Helene M., Cunningham, J. Thomas, Nejtek, Vicki A.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2022; Sage Publications Ltd; IOS Press
• Subjects: Aerobics; Animal models; Animals; Cognitive ability; Exercise; Exercise Test; Exercise Therapy - methods; Fitness equipment; Heart Rate; Human subjects; Humans; Infant; Locomotor activity; Movement disorders; Neurobiology; Neurodegenerative diseases; Parkinson Disease - genetics; Parkinson's disease; Physical fitness; Physical training; PTEN-induced putative kinase; Rats; Research Report; Translation; Exercise; Pink1; aging; cardiovascular; Parkinson’s disease; locomotor

Background: Rodent Parkinson’s disease (PD) models are valuable to interrogate neurobiological mechanisms of exercise that mitigate motor impairment. Translating these mechanisms to human PD must account for physical capabilities of the patient. Objective: To establish cardiovascular parameters as a...