The multifactorial origin of posterior reversible encephalopathy syndrome in cyclophosphamide-treated lupus patients

• Published in: Rheumatology international Vol. 37; no. 12; pp. 2105 - 2114
• Main Authors: Zekić, Tatjana, Benić, Mirjana Stanić, Antulov, Ronald, Antončić, Igor, Novak, Srđan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2017; Springer Nature B.V
• Subjects: Acute Disease; Adolescent; Brain - diagnostic imaging; Case Based Review; Cyclophosphamide - administration & dosage; Cyclophosphamide - adverse effects; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Lupus; Lupus Nephritis - drug therapy; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Patients; Posterior Leukoencephalopathy Syndrome - chemically induced; Posterior Leukoencephalopathy Syndrome - diagnosis; Rheumatology; Risk Factors; Status Epilepticus - chemically induced; Tomography, X-Ray Computed; Treatment Outcome; Cyclophosphamide; Systemic lupus erythematosus; Review; Posterior leukoencephalopathy syndrome

The cyclophosphamide as a predisposing factor for Posterior Reversible Encephalopathy Syndrome (PRES) and therapeutic option for systemic lupus erythematosus (SLE) is still confusing. The first and only case of PRES, probably induced by cyclophosphamide, in Croatia followed by the findings of 36 SLE...