Determination of trace elements in rat organs implanted with endodontic repair materials by ICP-MS

• Published in: Journal of materials science. Materials in medicine Vol. 27; no. 3; pp. 46 - 6
• Main Authors: Simsek, Neslihan, Bulut, Elçin Tekin, Ahmetoğlu, Fuat, Alan, Hilal
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2016; Springer Nature B.V
• Subjects: Aluminum Compounds - chemistry; Animals; Biocompatibility; Biocompatibility Studies; Biocompatible Materials; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Brain; Brain Chemistry; Calcium Compounds - chemistry; Calcium Hydroxide - chemistry; Ceramics; Chemistry and Materials Science; Chromium; Composites; Dental Materials - chemistry; Drug Combinations; Glass; Hydroxyapatites - chemistry; Kidney - chemistry; Kidneys; Liver; Liver - chemistry; Magnesium; Mass Spectrometry; Materials Science; Natural Materials; Organs; Oxides - chemistry; Polymer Sciences; Rats; Rats, Wistar; Regenerative Medicine/Tissue Engineering; Root Canal Filling Materials - chemistry; Silicates - chemistry; Surfaces and Interfaces; Thin Films; Trace elements; Trace Elements - metabolism; Simulated Body Fluid; Portland Cement; Tricalcium Silicate; Mineral Trioxide Aggregate; Dental Material
• DOI: 10.1007/s10856-015-5663-4
• ISSN: 0957-4530

To investigate the levels of seven elements using an inductively coupled plasma-mass spectrometry (ICP-MS) method in rat organs after the implantation of Micro Mega Mineral Trioxide Aggregate (MM-MTA), Bioaggregate (BA) and Biodentine (BD) materials. MM-MTA, BA and BD were implanted into the subcutaneous tissue of 15 Wistar albino rats; three control animals had no operation. After 45 days, the rats were sacrificed and their brains, kidneys and livers were removed. The ICP-MS analysis was used to determine trace elements. Data were analysed using the Kruskal–Wallis and Connover post hoc tests. There was no significant difference between the control groups and the MM-MTA, BA and BD groups according to the concentration of aluminum, calcium, arsenic and lead in the rats’ organs. Beryllium was not detected in all tissue samples. Chromium levels of these materials were higher than the control group in brain and kidney samples (P = 0.038 and P = 0.037); magnesium levels were higher than the control group in kidney and liver samples (P = 0.030 and P = 0.008). MM-MTA, BA and BD were nontoxic according to trace element levels in brain, kidney and liver samples of rats. Further investigation is required to understand the systemic effects of these materials.