Upregulation of Tissue and Urinary Nicotinamide N-Methyltransferase in Bladder Cancer: Potential for the Development of a Urine-Based Diagnostic Test

• Published in: Cell biochemistry and biophysics Vol. 65; no. 3; pp. 473 - 483
• Main Authors: Sartini, Davide, Muzzonigro, Giovanni, Milanese, Giulio, Pozzi, Valentina, Vici, Alexia, Morganti, Stefano, Rossi, Valentina, Mazzucchelli, Roberta, Montironi, Rodolfo, Emanuelli, Monica
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.04.2013; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Biochemistry; Biological and Medical Physics; Biomarkers, Tumor - urine; Biomedical and Life Sciences; Biophysics; Biotechnology; Bladder cancer; Cell Biology; Cohort Studies; Cytology; Female; Gene Expression Regulation, Neoplastic; Humans; Life Sciences; Male; Middle Aged; Neoplasm Grading; Nicotinamide N-Methyltransferase - genetics; Nicotinamide N-Methyltransferase - metabolism; Nicotinamide N-Methyltransferase - urine; Oligonucleotide Array Sequence Analysis; Original Paper; Pharmacology/Toxicology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Up-Regulation; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - pathology; Urine; Diagnostic marker; NNMT; Carcinoma; Gene expression

Carcinoma of the bladder is one of the most common urologic malignancies occurring worldwide. Diagnosis and monitoring of bladder urothelial carcinoma (UC) are based on cystoscopy and urinary cytology. However, these diagnostic methods still have some limitations, mainly related to invasive nature a...