Tolerability of different doses of oliceridine versus traditional opioids in acute pain management: a systematic review and meta-analysis

• Published in: Scientific reports Vol. 15; no. 1; pp. 11470 - 14
• Main Authors: Liu, Yulin, Zhu, Ying, Fu, Hong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.04.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 692/1807/1676; 692/1807/1876; 692/1807/244; 692/1807/4018; 692/1807/410; 692/308; 692/308/409; 692/699; Acute pain; Acute Pain - drug therapy; Analgesia; Analgesics; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - adverse effects; Analgesics, Opioid - therapeutic use; Anesthesia; Benchmarks; Clinical trials; Dose-Response Relationship, Drug; Drug therapy; Humanities and Social Sciences; Humans; Hypoxemia; Meta-analysis; Morphine; Morphine - administration & dosage; Morphine - adverse effects; Morphine - therapeutic use; multidisciplinary; Nausea; Oliceridine; Pain; Pain management; Pain Management - methods; Pain perception; Pruritus; Randomized Controlled Trials as Topic; Safety; Science; Science (multidisciplinary); Sensitivity analysis; Spiro Compounds - administration & dosage; Spiro Compounds - adverse effects; Spiro Compounds - therapeutic use; Systematic review; Thiophenes; Tolerability; Vomiting; Oliceridine; Tolerability; Acute pain; Safety; Meta-analysis

This study aims to deliver a systematic review and meta-analysis to scrutinize the tolerability of different doses of oliceridine in acute pain patients. A comprehensive search was carried out in essential databases (PubMed, Embase, Cochrane Library, and Web of Science) for relevant studies up to th...