Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging
Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role in the early stages of microvascular related brain disorders. A better understanding of its underlying pathophysiological mechanisms, and met...
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Published in | Journal of Cerebral Blood Flow & Metabolism Vol. 42; no. 5; pp. 718 - 737 |
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Main Authors | , , , , , , |
Format | Book Review Journal Article |
Language | English |
Published |
London, England
SAGE Publications
01.05.2022
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Subjects | |
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Abstract | Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role in the early stages of microvascular related brain disorders. A better understanding of its underlying pathophysiological mechanisms, and methods to measure microvascular density in the human brain are needed to develop biomarkers for early diagnosis and to identify targets for disease modifying treatments. Therefore, we provide an overview of the assumed main pathophysiological processes underlying cerebral microvascular rarefaction and the evidence for rarefaction in several microvascular related brain disorders. A number of advanced physiological MRI techniques can be used to measure the pathological alterations associated with microvascular rarefaction. Although more research is needed to explore and validate these MRI techniques in microvascular rarefaction in brain disorders, they provide a set of promising future tools to assess various features relevant for rarefaction, such as cerebral blood flow and volume, vessel density and radius and blood-brain barrier leakage. |
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AbstractList | Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role in the early stages of microvascular related brain disorders. A better understanding of its underlying pathophysiological mechanisms, and methods to measure microvascular density in the human brain are needed to develop biomarkers for early diagnosis and to identify targets for disease modifying treatments. Therefore, we provide an overview of the assumed main pathophysiological processes underlying cerebral microvascular rarefaction and the evidence for rarefaction in several microvascular related brain disorders. A number of advanced physiological MRI techniques can be used to measure the pathological alterations associated with microvascular rarefaction. Although more research is needed to explore and validate these MRI techniques in microvascular rarefaction in brain disorders, they provide a set of promising future tools to assess various features relevant for rarefaction, such as cerebral blood flow and volume, vessel density and radius and blood-brain barrier leakage. Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role in the early stages of microvascular related brain disorders. A better understanding of its underlying pathophysiological mechanisms, and methods to measure microvascular density in the human brain are needed to develop biomarkers for early diagnosis and to identify targets for disease modifying treatments. Therefore, we provide an overview of the assumed main pathophysiological processes underlying cerebral microvascular rarefaction and the evidence for rarefaction in several microvascular related brain disorders. A number of advanced physiological MRI techniques can be used to measure the pathological alterations associated with microvascular rarefaction. Although more research is needed to explore and validate these MRI techniques in microvascular rarefaction in brain disorders, they provide a set of promising future tools to assess various features relevant for rarefaction, such as cerebral blood flow and volume, vessel density and radius and blood-brain barrier leakage. |
Author | Staals, Julie Jansen, Jacobus FA Jones, Elizabeth AV Backes, Walter H van Dinther, Maud Voorter, Paulien HM van Oostenbrugge, Robert J |
Author_xml | – sequence: 1 givenname: Maud orcidid: 0000-0001-7349-4783 surname: van Dinther fullname: van Dinther, Maud organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium – sequence: 2 givenname: Paulien HM surname: Voorter fullname: Voorter, Paulien HM organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium – sequence: 3 givenname: Jacobus FA surname: Jansen fullname: Jansen, Jacobus FA organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium – sequence: 4 givenname: Elizabeth AV surname: Jones fullname: Jones, Elizabeth AV organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium – sequence: 5 givenname: Robert J surname: van Oostenbrugge fullname: van Oostenbrugge, Robert J organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium – sequence: 6 givenname: Julie surname: Staals fullname: Staals, Julie organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium – sequence: 7 givenname: Walter H surname: Backes fullname: Backes, Walter H organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35078344$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1007_s40477_023_00867_4 crossref_primary_10_1016_j_jbc_2023_105221 crossref_primary_10_1161_HYPERTENSIONAHA_123_19939 crossref_primary_10_3389_fncel_2022_876746 crossref_primary_10_3390_medicina59091596 crossref_primary_10_1016_j_vph_2024_107393 crossref_primary_10_3390_medicina59071337 crossref_primary_10_1016_j_biopsych_2023_07_023 crossref_primary_10_1016_j_exger_2024_112510 crossref_primary_10_1016_j_bpsc_2024_03_005 crossref_primary_10_1007_s11357_023_00748_y crossref_primary_10_1162_imag_a_00066 crossref_primary_10_1159_000529067 |
Cites_doi | 10.1016/0197-4580(86)90158-2 10.1113/JP277425 10.1097/nen.0b013e3180537147 10.3348/kjr.2014.15.5.554 10.1038/s41569-018-0030-z 10.1016/0197-4580(90)90001-G 10.1371/journal.pone.0030444 10.1097/HJH.0000000000000021 10.1113/jphysiol.2014.271213 10.1038/nrn3114 10.1038/ncomms15557 10.1002/mrm.25396 10.1016/S0197-4580(03)00111-8 10.1038/s41598-018-26475-5 10.1667/RR3453.1 10.1002/jmri.24864 10.1016/j.jalz.2010.04.004 10.1016/S0197-4580(01)00285-8 10.1007/BF00294173 10.1148/radiol.2016152244 10.1016/j.nicl.2018.08.030 10.1016/j.devcel.2011.07.001 10.1038/s41598-018-37564-w 10.1016/j.pscychresns.2008.11.006 10.1002/jmri.26920 10.1007/BF00294246 10.1007/BF00690372 10.3233/JAD-2010-100219 10.1007/s10334-009-0190-2 10.1016/j.jns.2007.01.015 10.1152/ajpheart.00377.2013 10.1148/radiol.2333020981 10.1179/016164104225016272 10.1038/nature09522 10.1002/mrm.1910270116 10.1016/0361-9230(90)90007-M 10.1073/pnas.0905891106 10.1111/micc.12263 10.1002/mrm.25197 10.1038/cddis.2013.517 10.1097/MNH.0b013e328344c3d4 10.1073/pnas.0400337101 10.1007/s11357-020-00211-2 10.1038/jcbfm.2011.153 10.1111/j.1365-2990.2010.01139.x 10.3390/ijms18091897 10.1016/j.yexcr.2007.07.023 10.1002/nbm.2833 10.1006/exnr.1993.1095 10.1016/j.bbadis.2013.08.007 10.1210/endo.138.8.5330 10.1093/gerona/glu080 10.1038/jcbfm.2014.226 10.1152/ajpheart.01024.2010 10.1111/apha.12250 10.1016/j.neuron.2013.10.008 10.1097/MD.0000000000004206 10.1177/0271678X16662891 10.1016/j.acra.2013.01.020 10.1371/journal.pone.0038692 10.1016/S0306-4522(01)00378-5 10.1016/j.jns.2009.02.328 10.3389/neuro.24.004.2009 10.1038/kisup.2014.9 10.1111/acel.12731 10.2337/dc14-2043 10.3390/ijms14011412 10.1148/radiology.168.2.3393671 10.1007/BF00227737 10.1148/radiology.161.2.3763909 10.1212/WNL.0000000000003556 10.2353/ajpath.2007.070050 10.1080/13506120701814723 10.1161/01.STR.0000024523.82311.77 10.1212/WNL.59.3.321 10.1016/j.pnmrs.2019.09.002 10.1002/1522-2586(200009)12:3<381::AID-JMRI2>3.0.CO;2-Y 10.1002/nbm.2940 10.1016/j.neuroimage.2019.116228 10.1016/j.neuron.2010.09.043 10.1016/j.neubiorev.2016.11.023 10.1016/j.jalz.2019.01.013 10.1007/s00125-011-2200-y 10.1038/kisup.2014.20 10.1017/S0317167100037124 10.1016/j.neurobiolaging.2016.11.004 10.1007/s00234-015-1571-z 10.1073/pnas.90.22.10836 10.1016/j.neurobiolaging.2019.09.017 10.1093/gerona/gls242 10.1007/s10456-015-9465-6 10.1080/713774024 10.1002/ana.410280313 10.1002/mrm.22002 10.1016/j.nicl.2015.04.012 10.1212/WNL.0000000000007263 10.1002/mrm.20383 10.1093/gerona/glt177 10.1177/0271678X17713434 10.1053/jscd.2003.1 10.3389/fphys.2021.643468 10.1097/RLI.0000000000000723 10.1172/JCI39733 10.1111/j.1752-8062.2008.00016.x 10.1007/s11357-016-9931-0 10.1111/j.1440-1789.2006.00701.x 10.1007/s11906-010-0114-6 10.1016/j.jns.2012.07.010 10.1007/s00234-019-02292-z 10.1016/j.redox.2019.101192 10.1016/j.jstrokecerebrovasdis.2017.03.002 10.3233/JAD-2004-6404 10.1152/japplphysiol.00966.2005 10.1001/archneur.1991.00530220089024 10.1016/j.nicl.2019.102146 10.1016/S1474-4422(19)30079-1 10.1161/HYPERTENSIONAHA.113.01063 10.1136/bmj.38814.696493.AE 10.1097/RCT.0000000000000640 10.1159/000365149 10.1161/HYPERTENSIONAHA.119.13752 10.1016/j.neurobiolaging.2021.06.017 10.3389/fneur.2020.545450 10.1016/0026-2862(85)90032-9 10.1097/MD.0000000000020463 10.1016/j.nicl.2017.01.017 10.1097/00001756-199502000-00018 10.1016/S1474-4422(13)70124-8 10.1002/jmri.27272 10.2353/ajpath.2008.080433 10.1161/STR.0b013e3182299496 10.1152/ajpheart.00308.2014 10.1148/radiol.2016150789 10.1093/gerona/glq113 10.1161/01.HYP.6.3.408 10.1201/9780429427275-4 10.1016/j.ijrobp.2007.09.059 10.1161/01.STR.23.11.1673 10.1016/j.devcel.2015.06.004 10.1007/s11357-019-00139-2 10.1242/dev.120.12.3395 10.4161/org.6.1.10427 |
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Keywords | cerebral small vessel disease magnetic resonance imaging Alzheimer’s disease microvascular density microvascular rarefaction |
Language | English |
License | This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
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References | García-Amado, Prensa 2012; 7 Ungvari, Tucsek, Sosnowska 2013; 68 Suzuki, Masawa, Sakata 2003; 12 Korn, Augustin 2015; 34 Zhang, Wong, van de Haar 2017; 88 Zlokovic 2011; 12 Iadecola 2013; 80 Le Bihan, Turner 1992; 27 Tong, Hamel 2015; 35 Sleight, Stringer, Marshall 2021; 12 Shin, Huang, Gurel 2014; 5 Willats, Calamante 2013; 26 Choi, Ryu, Kim 2020 Tarantini, Tucsek, Valcarcel-Ares 2016; 38 Yang, Bae, Kang 2004; 25 Brown 2010; 21 Elschot, Backes, Postma 2021; 56 van der Thiel, Freeze, Verheggen 2021; 106 Sasongko, Wong, Nguyen 2011; 54 Brown, Moody, Thore 2007; 257 Suter, Sunthorn, Kraftsik 2002; 33 Schrimpf, Duffield 2011; 20 Chen, Prewitt, Dowell 1981; 241 Chakhoyan, Yao, Leu 2019; 9 Brickman, Zahra, Muraskin 2009; 172 Le Bihan, Breton, Lallemand 1988; 168 Muoio, Persson, Sendeski 2014; 210 Ashpole, Warrington, Mitschelen 2014; 307 Kiselev, Strecker, Ziyeh 2005; 53 Prewitt 1990 Lang, Lustig, Francois 1994; 120 Chiaravalloti, Fiorentini, Francesco 2016; 95 Wong, Backes, Drenthen 2020; 51 Girouard, Iadecola 2006; 100 Thore, Anstrom, Moody 2007; 66 Brown, Thore 2011; 37 Kalaria, Hedera 1995; 6 Freeze, Jacobs, de Jong 2020; 85 Kawakami, Mimura, Shoji 2014; 4 Arba, Mair, Carpenter 2017; 26 Challa, Thore, Moody 2004; 6 Baloyannis, Baloyannis 2012; 322 Wardlaw, Smith, Biessels 2013; 12 Bell, Winkler, Sagare 2010; 68 Wardlaw, Smith, Dichgans 2019; 18 Harper, Bohlen 1984; 6 Tucsek, Toth, Tarantini 2014; 69 Troprès, Pannetier, Grand 2015; 73 Sokolova, Manukhina, Blinkov 1985; 30 Paschoal, Leoni, Dos Santos 2018; 20 Yao, Sadoshima, Ibayashi 1992; 23 Perlmutter, Chui 1990; 24 Bell, Ball 1981; 53 Sonntag, Lynch, Cooney 1997; 138 Thrippleton 2019; 597 Purandare, Burns, Daly 2006; 332 Yannoutsos, Levy, Safar 2014; 32 Olenich, Audet, Roberts 2014; 592 Wilhelmus, Otte-Holler, van Triel 2007; 171 Ungvari, Tarantini, Kiss 2018; 15 Chen, Song, Beyea 2011; 7 Lin, Kisseleva, Brenner 2008; 173 Armulik, Genové, Mäe 2010; 468 Wong, Jansen, Zhang 2019; 92 Malaguarnera, Motta, Di Rosa 2006; 26 Toth, Csiszar, Tucsek 2013; 305 O'Sullivan, Lythgoe, Pereira 2002; 59 Vieni, Ades-Aron, Conti 2020; 204 Jespersen, Østergaard 2012; 32 Faraco, Iadecola 2013; 62 Dickie, Parker, Parkes 2020; 116 Moody, Thore, Anstrom 2004; 233 Promjunyakul, Lahna, Kaye 2015; 8 Yung, Chae, Buehler 2009; 106 Oomen, Farkas, Roman 2009; 1 Lopez-Lopez, LeRoith, Torres-Aleman 2004; 101 Bell, Ball 1986; 13 Hu, Lv, Li 2020; 99 Warrington, Csiszar, Johnson 2011; 300 Eskildsen, Gyldensted, Nagenthiraja 2017; 50 Dolui, Li, Nasrallah 2020; 25 van Osch, Teeuwisse, van Walderveen 2009; 62 Jahng, Li, Ostergaard 2014; 15 Ko, Cao, Liu 2010; 12 Meguro, Hatazawa, Yamaguchi 1990; 28 Haller, Zaharchuk, Thomas 2016; 281 Dong, Zeitlin, Song 2007; 313 Norling, Gerstenecker, Buford 2020; 42 Pavilla, Arrigo, Mejdoubi 2018; 42 Shi, Thrippleton, Makin 2016; 36 Kellner, Breyer, Gall 2015; 42 Gorelick, Scuteri, Black 2011; 42 Tarantini, Valcarcel-Ares, Toth 2019; 24 Wong, Zhang, van Bussel 2017; 14 Vogt, Schmid-Schonbein 2001; 8 Lichtenwalner, Forbes, Bennett 2001; 107 Li, Bentzen, Li 2008; 71 Grade, Hernandez Tamames, Pizzini 2015; 57 Patel, Quadros, Brem 2008; 15 Ballermann, Obeidat 2014; 4 Knutsson, Ståhlberg, Wirestam 2010; 23 Joutel, Monet-Lepretre, Gosele 2010; 120 Fischer, Siddiqi, Yusufaly 1990; 79 Nelis, Kleffner, Burg 2018; 8 van Bussel, Backes, Hofman 2015; 38 Mann, Eaves, Marcyniuk 1986; 7 Cheng, Diamond, Falkner 2008; 1 Tian, Bai, Yang 2013; 14 Sourbron, Buckley 2013; 26 Thiel, Gaisl, Lettau 2019; 61 Abernethy, Bell, Morris 1993; 121 Sung, Michael, Nagy 2010; 17 Fonseca, Ferreiro, Oliveira 2013; 1832 Li, Chen, Haimovitz-Friedman 2003; 63 Le Bihan, Breton, Lallemand 1986; 161 Alsop, Detre, Golay 2015; 73 Moore, Zhang, Maeda 2015; 18 Tarkowski, Issa, Sjögren 2002; 23 van Osch, Teeuwisse, Chen 2018; 38 Yamauchi, Fukuyama, Yamaguchi 1991; 48 Warrington, Csiszar, Mitschelen 2012; 7 Thrippleton, Backes, Sourbron 2019; 15 Bell, Ball 1990; 11 Brown, Thore, Moody 2005; 164 Roher, Lowenson, Clarke 1993; 90 Zhang, Gordon, Goldberg 2017; 72 Brown, Moody, Thore 2009; 283 Olfert 2016; 23 Tucsek, Toth, Sosnowska 2014; 69 Buee, Hof, Bouras 1994; 87 Bailey, Rivara, Rocher 2004; 26 Speck, Chang, DeSilva 2000; 12 Hauser, Schönknecht, Thomann 2013; 20 Morland, Andersson, Haugen 2017; 8 Miura, Saitoh, Kokubun 2017; 18 Bergamino, Nespodzany, Baxter 2020; 52 Tarantini, Valcarcel-Ares, Yabluchanskiy 2018; 17 Goligorsky 2010; 6 Schrimpf, Teebken, Wilhelmi 2014; 51 Kalaria, Kroon 1992; 84 van de Haar, Burgmans, Jansen 2016; 281 Ungvari, Kaley, de Cabo 2010; 65 Zhang, Gordon, Ma 2018 Armulik, Genové, Betsholtz 2011; 21 Tapp, Owen, Barman 2019; 74 Verheggen, de Jong, van Boxtel 2020; 42 Yamaguchi, Yamazaki, Lemere 1992; 141 bibr52-0271678X221076557 bibr78-0271678X221076557 bibr135-0271678X221076557 bibr1-0271678X221076557 bibr65-0271678X221076557 bibr122-0271678X221076557 bibr11-0271678X221076557 bibr80-0271678X221076557 bibr107-0271678X221076557 bibr51-0271678X221076557 bibr24-0271678X221076557 bibr108-0271678X221076557 bibr37-0271678X221076557 bibr64-0271678X221076557 bibr148-0271678X221076557 bibr77-0271678X221076557 bibr91-0271678X221076557 bibr23-0271678X221076557 bibr109-0271678X221076557 bibr49-0271678X221076557 bibr81-0271678X221076557 bibr119-0271678X221076557 Yamaguchi H (bibr73-0271678X221076557) 1992; 141 bibr79-0271678X221076557 bibr89-0271678X221076557 bibr124-0271678X221076557 bibr39-0271678X221076557 bibr3-0271678X221076557 bibr13-0271678X221076557 bibr63-0271678X221076557 bibr53-0271678X221076557 bibr134-0271678X221076557 bibr93-0271678X221076557 bibr123-0271678X221076557 bibr133-0271678X221076557 bibr48-0271678X221076557 bibr149-0271678X221076557 bibr38-0271678X221076557 bibr22-0271678X221076557 bibr2-0271678X221076557 bibr12-0271678X221076557 bibr75-0271678X221076557 bibr138-0271678X221076557 bibr62-0271678X221076557 bibr55-0271678X221076557 bibr4-0271678X221076557 bibr82-0271678X221076557 bibr90-0271678X221076557 bibr95-0271678X221076557 bibr9-0271678X221076557 bibr70-0271678X221076557 bibr67-0271678X221076557 Zhang N (bibr129-0271678X221076557) 2018 bibr104-0271678X221076557 bibr47-0271678X221076557 bibr27-0271678X221076557 bibr118-0271678X221076557 bibr87-0271678X221076557 bibr10-0271678X221076557 bibr131-0271678X221076557 bibr141-0271678X221076557 bibr20-0271678X221076557 Li YQ (bibr92-0271678X221076557) 2003; 63 bibr40-0271678X221076557 bibr30-0271678X221076557 bibr101-0271678X221076557 bibr111-0271678X221076557 bibr121-0271678X221076557 bibr50-0271678X221076557 bibr6-0271678X221076557 bibr60-0271678X221076557 bibr146-0271678X221076557 bibr25-0271678X221076557 bibr15-0271678X221076557 bibr35-0271678X221076557 bibr126-0271678X221076557 bibr136-0271678X221076557 bibr116-0271678X221076557 bibr45-0271678X221076557 bibr106-0271678X221076557 bibr102-0271678X221076557 bibr17-0271678X221076557 bibr98-0271678X221076557 Chen II (bibr7-0271678X221076557) 1981; 241 bibr128-0271678X221076557 bibr72-0271678X221076557 bibr85-0271678X221076557 bibr115-0271678X221076557 bibr44-0271678X221076557 bibr142-0271678X221076557 bibr31-0271678X221076557 Sung HK (bibr19-0271678X221076557) 2010; 17 bibr97-0271678X221076557 bibr84-0271678X221076557 bibr71-0271678X221076557 bibr57-0271678X221076557 bibr59-0271678X221076557 bibr69-0271678X221076557 Prewitt R. (bibr8-0271678X221076557) 1990 bibr29-0271678X221076557 bibr114-0271678X221076557 bibr33-0271678X221076557 bibr144-0271678X221076557 bibr43-0271678X221076557 bibr83-0271678X221076557 bibr143-0271678X221076557 bibr18-0271678X221076557 bibr28-0271678X221076557 bibr58-0271678X221076557 bibr139-0271678X221076557 bibr99-0271678X221076557 bibr32-0271678X221076557 bibr103-0271678X221076557 bibr42-0271678X221076557 bibr113-0271678X221076557 bibr125-0271678X221076557 bibr88-0271678X221076557 bibr105-0271678X221076557 bibr14-0271678X221076557 bibr112-0271678X221076557 bibr68-0271678X221076557 bibr54-0271678X221076557 bibr21-0271678X221076557 bibr34-0271678X221076557 bibr41-0271678X221076557 bibr61-0271678X221076557 bibr132-0271678X221076557 bibr74-0271678X221076557 bibr145-0271678X221076557 bibr94-0271678X221076557 bibr46-0271678X221076557 bibr16-0271678X221076557 bibr137-0271678X221076557 bibr66-0271678X221076557 bibr147-0271678X221076557 bibr76-0271678X221076557 bibr56-0271678X221076557 bibr127-0271678X221076557 bibr36-0271678X221076557 bibr26-0271678X221076557 bibr117-0271678X221076557 bibr110-0271678X221076557 bibr96-0271678X221076557 bibr86-0271678X221076557 bibr5-0271678X221076557 bibr140-0271678X221076557 bibr130-0271678X221076557 bibr120-0271678X221076557 bibr100-0271678X221076557 |
References_xml | – volume: 300 start-page: H736 year: 2011 end-page: 744 article-title: Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in mice publication-title: Am J Physiol Heart Circ Physiol contributor: fullname: Johnson – volume: 17 start-page: e12731 year: 2018 article-title: Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice publication-title: Aging Cell contributor: fullname: Yabluchanskiy – volume: 173 start-page: 1617 year: 2008 end-page: 1627 article-title: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney publication-title: Am J Pathol contributor: fullname: Brenner – volume: 7 start-page: e38692 year: 2012 article-title: Stereological analysis of neuron, glial and endothelial cell numbers in the human amygdaloid complex. publication-title: PLoS One contributor: fullname: Prensa – volume: 1 start-page: 75 year: 2008 end-page: 79 article-title: Functional capillary rarefaction in mild blood pressure elevation publication-title: Clin Translational Sci contributor: fullname: Falkner – volume: 12 start-page: 381 year: 2000 end-page: 387 article-title: Perfusion MRI of the human brain with dynamic susceptibility contrast: gradient-echo versus spin-echo techniques publication-title: J Magn Reson Imaging contributor: fullname: DeSilva – volume: 62 start-page: 165 year: 2009 end-page: 173 article-title: Can arterial spin labeling detect white matter perfusion signal? publication-title: Magn Reson Med contributor: fullname: van Walderveen – volume: 42 start-page: 141 year: 2020 end-page: 158 article-title: The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension publication-title: Geroscience contributor: fullname: Buford – volume: 210 start-page: 790 year: 2014 end-page: 798 article-title: The neurovascular unit – concept review publication-title: Acta Physiol (Oxf) contributor: fullname: Sendeski – volume: 99 start-page: e20463 year: 2020 article-title: Effect of post-labeling delay on regional cerebral blood flow in arterial spin-labeling MR imaging publication-title: Medicine (Baltimore) contributor: fullname: Li – volume: 18 start-page: 1897 year: 2017 article-title: Mitochondrial-Targeted antioxidant maintains blood flow, mitochondrial function, and redox balance in old mice following prolonged limb ischemia publication-title: IJMS contributor: fullname: Kokubun – volume: 73 start-page: 325 year: 2015 end-page: 341 article-title: Imaging the microvessel caliber and density: Principles and applications of microvascular MRI publication-title: Magn Reson Med contributor: fullname: Grand – volume: 6 start-page: 477 year: 1995 end-page: 480 article-title: Differential degeneration of the cerebral microvasculature in Alzheimer's disease publication-title: Neuroreport contributor: fullname: Hedera – volume: 23 start-page: 146 year: 2016 end-page: 156 article-title: Physiological capillary regression is not dependent on reducing VEGF expression publication-title: Microcirculation contributor: fullname: Olfert – volume: 141 start-page: 249 year: 1992 end-page: 259 article-title: Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study publication-title: Am J Pathol contributor: fullname: Lemere – volume: 52 start-page: 1811 year: 2020 end-page: 1826 article-title: Preliminary assessment of intravoxel incoherent motion Diffusion-Weighted MRI (IVIM-DWI) metrics in Alzheimer's disease publication-title: J Magn Reson Imaging contributor: fullname: Baxter – volume: 8 start-page: 8148 year: 2018 article-title: OCT-Angiography reveals reduced vessel density in the deep retinal plexus of CADASIL patients publication-title: Sci Rep contributor: fullname: Burg – volume: 313 start-page: 3645 year: 2007 end-page: 3657 article-title: Level of endothelial cell apoptosis required for a significant decrease in microvessel density publication-title: Exp Cell Res contributor: fullname: Song – volume: 116 start-page: 19 year: 2020 end-page: 39 article-title: Measuring water exchange across the blood-brain barrier using MRI publication-title: Prog Nucl Magn Reson Spectrosc contributor: fullname: Parkes – volume: 9 start-page: 2846 year: 2019 article-title: Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry publication-title: Sci Rep contributor: fullname: Leu – start-page: 71 year: 1990 end-page: 79 article-title: Structural and functional rarefaction of microvessels in hypertension publication-title: Blood Vessel Changes Hypertens: Struct Func contributor: fullname: Prewitt – volume: 26 start-page: 1506 year: 2017 end-page: 1513 article-title: Cerebral white matter hypoperfusion increases with small-vessel disease burden. Data from the third international stroke trial publication-title: J Stroke Cerebrovasc Dis contributor: fullname: Carpenter – volume: 4 start-page: 107 year: 2014 end-page: 112 article-title: Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes publication-title: Kidney Int Suppl (2011) contributor: fullname: Shoji – volume: 24 start-page: 677 year: 1990 end-page: 686 article-title: Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review publication-title: Brain Res Bull contributor: fullname: Chui – volume: 106 start-page: 15279 year: 2009 end-page: 15284 article-title: Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells publication-title: Proc Natl Acad Sci U S A contributor: fullname: Buehler – volume: 138 start-page: 3515 year: 1997 end-page: 3520 article-title: Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1 publication-title: Endocrinology contributor: fullname: Cooney – volume: 71 start-page: 64 year: 2008 end-page: 70 article-title: Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Li – volume: 38 start-page: 876 year: 2015 end-page: 882 article-title: On the interplay of microvasculature, parenchyma, and memory in type 2 diabetes publication-title: Diabetes Care contributor: fullname: Hofman – volume: 90 start-page: 10836 year: 1993 end-page: 10840 article-title: beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease publication-title: Proc Natl Acad Sci U S A contributor: fullname: Clarke – volume: 34 start-page: 5 year: 2015 end-page: 17 article-title: Mechanisms of vessel pruning and regression publication-title: Dev Cell contributor: fullname: Augustin – volume: 18 start-page: 684 year: 2019 end-page: 696 article-title: Small vessel disease: mechanisms and clinical implications publication-title: Lancet Neurol contributor: fullname: Dichgans – volume: 257 start-page: 62 year: 2007 end-page: 66 article-title: Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well publication-title: J Neurol Sci contributor: fullname: Thore – volume: 38 start-page: 273 year: 2016 end-page: 289 article-title: Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging publication-title: Age (Dordr) contributor: fullname: Valcarcel-Ares – volume: 69 start-page: 1212 year: 2014 end-page: 1226 article-title: Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease publication-title: J Gerontol A Biol Sci Med Sci contributor: fullname: Sosnowska – volume: 15 start-page: 555 year: 2018 end-page: 565 article-title: Endothelial dysfunction and angiogenesis impairment in the ageing vasculature publication-title: Nat Rev Cardiol contributor: fullname: Kiss – volume: 42 start-page: 1117 year: 2015 end-page: 1125 article-title: MR evaluation of vessel size imaging of human gliomas: Validation by histopathology publication-title: J Magn Reson Imaging contributor: fullname: Gall – volume: 24 start-page: 101192 year: 2019 article-title: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice publication-title: Redox Biol contributor: fullname: Toth – volume: 14 start-page: 216 year: 2017 end-page: 221 article-title: Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging publication-title: Neuroimage Clin contributor: fullname: van Bussel – volume: 95 start-page: e4206 year: 2016 article-title: Is cerebral glucose metabolism related to blood-brain barrier dysfunction and intrathecal IgG synthesis in Alzheimer disease?: a 18F-FDG PET/CT study publication-title: Medicine (Baltimore) contributor: fullname: Francesco – volume: 56 start-page: 10 year: 2021 end-page: 19 article-title: A comprehensive view on MRI techniques for imaging Blood-Brain barrier integrity publication-title: Invest Radiol contributor: fullname: Postma – volume: 66 start-page: 337 year: 2007 end-page: 345 article-title: Morphometric analysis of arteriolar tortuosity in human cerebral white matter of preterm, young, and aged subjects publication-title: J Neuropathol Exp Neurol contributor: fullname: Moody – volume: 7 start-page: 185 year: 2011 end-page: 196 article-title: Advances in perfusion magnetic resonance imaging in Alzheimer's disease publication-title: Alzheimers Dement contributor: fullname: Beyea – volume: 57 start-page: 1181 year: 2015 end-page: 1202 article-title: A neuroradiologist's guide to arterial spin labeling MRI in clinical practice publication-title: Neuroradiology contributor: fullname: Pizzini – volume: 20 start-page: 705 year: 2013 end-page: 711 article-title: Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI publication-title: Acad Radiol contributor: fullname: Thomann – volume: 17 start-page: 206 year: 2010 end-page: 212 article-title: Multifaceted role of vascular endothelial growth factor signaling in adult tissue physiology: an emerging concept with clinical implications publication-title: Curr Opin Hematol contributor: fullname: Nagy – volume: 23 start-page: 1 year: 2010 end-page: 21 article-title: Absolute quantification of perfusion using dynamic susceptibility contrast MRI: pitfalls and possibilities publication-title: Magma contributor: fullname: Wirestam – volume: 1832 start-page: 2191 year: 2013 end-page: 2203 article-title: Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells publication-title: Biochim Biophys Acta contributor: fullname: Oliveira – volume: 35 start-page: 512 year: 2015 end-page: 520 article-title: Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease publication-title: J Cereb Blood Flow Metab contributor: fullname: Hamel – volume: 27 start-page: 171 year: 1992 end-page: 178 article-title: The capillary network: a link between IVIM and classical perfusion publication-title: Magn Reson Med contributor: fullname: Turner – volume: 204 start-page: 116228 year: 2020 article-title: Effect of intravoxel incoherent motion on diffusion parameters in normal brain publication-title: Neuroimage contributor: fullname: Conti – volume: 25 start-page: 102146 year: 2020 article-title: Arterial spin labeling versus (18)F-FDG-PET to identify mild cognitive impairment publication-title: Neuroimage Clin contributor: fullname: Nasrallah – volume: 33 start-page: 1986 year: 2002 end-page: 1992 article-title: Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease publication-title: Stroke contributor: fullname: Kraftsik – volume: 62 start-page: 810 year: 2013 end-page: 817 article-title: Hypertension: a harbinger of stroke and dementia publication-title: Hypertension contributor: fullname: Iadecola – volume: 307 start-page: H858 year: 2014 end-page: 868 article-title: Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells publication-title: Am J Physiol Heart Circ Physiol contributor: fullname: Mitschelen – volume: 6 start-page: 1 year: 2010 end-page: 10 article-title: Microvascular rarefaction the decline and fall of blood vessels publication-title: Organogenesis contributor: fullname: Goligorsky – volume: 12 start-page: 723 year: 2011 end-page: 738 article-title: Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders publication-title: Nat Rev Neurosci contributor: fullname: Zlokovic – volume: 100 start-page: 328 year: 2006 end-page: 335 article-title: Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease publication-title: J Appl Physiol (1985) contributor: fullname: Iadecola – volume: 69 start-page: 1339 year: 2014 end-page: 1352 article-title: Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice publication-title: J Gerontol A Biol Sci Med Sci contributor: fullname: Tarantini – volume: 283 start-page: 28 year: 2009 end-page: 31 article-title: Microvascular changes in the white mater in dementia publication-title: J Neurol Sci contributor: fullname: Thore – volume: 80 start-page: 844 year: 2013 end-page: 866 article-title: The pathobiology of vascular dementia publication-title: Neuron contributor: fullname: Iadecola – volume: 37 start-page: 56 year: 2011 end-page: 74 article-title: Review: cerebral microvascular pathology in ageing and neurodegeneration publication-title: Neuropathol Appl Neurobiol contributor: fullname: Thore – volume: 20 start-page: 705 year: 2018 end-page: 714 article-title: Intravoxel incoherent motion MRI in neurological and cerebrovascular diseases publication-title: Neuroimage Clin contributor: fullname: Dos Santos – volume: 121 start-page: 270 year: 1993 end-page: 274 article-title: Microvascular density of the human paraventricular nucleus decreases with aging but not hypertension publication-title: Exp Neurol contributor: fullname: Morris – volume: 164 start-page: 662 year: 2005 end-page: 668 article-title: Vascular damage after fractionated whole-brain irradiation in rats publication-title: Radiat Res contributor: fullname: Moody – volume: 48 start-page: 1067 year: 1991 end-page: 1071 article-title: High-intensity area in the deep white matter indicating hemodynamic compromise in internal carotid artery occlusive disorders publication-title: Arch Neurol contributor: fullname: Yamaguchi – volume: 8 year: 2017 article-title: Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 publication-title: Nat Commun contributor: fullname: Haugen – volume: 38 start-page: 1461 year: 2018 end-page: 1480 article-title: Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow publication-title: J Cereb Blood Flow Metab contributor: fullname: Chen – volume: 6 start-page: 408 year: 1984 end-page: 419 article-title: Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats publication-title: Hypertension contributor: fullname: Bohlen – volume: 322 start-page: 117 year: 2012 end-page: 121 article-title: The vascular factor in Alzheimer's disease: a study in Golgi technique and electron microscopy publication-title: J Neurol Sci contributor: fullname: Baloyannis – volume: 4 start-page: 45 year: 2014 end-page: 52 article-title: Tipping the balance from angiogenesis to fibrosis in CKD publication-title: Kidney Int Suppl (2011) contributor: fullname: Obeidat – volume: 79 start-page: 672 year: 1990 end-page: 679 article-title: Altered angioarchitecture in selected areas of brains with Alzheimer's disease publication-title: Acta Neuropathol contributor: fullname: Yusufaly – volume: 32 start-page: 216 year: 2014 end-page: 224 article-title: Pathophysiology of hypertension: interactions between macro and microvascular alterations through endothelial dysfunction publication-title: J Hypertens contributor: fullname: Safar – volume: 597 start-page: 667 year: 2019 end-page: 668 article-title: MRI measurement of blood-brain barrier leakage: minding the gaps publication-title: J Physiol contributor: fullname: Thrippleton – volume: 8 start-page: 224 year: 2015 end-page: 229 article-title: Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures publication-title: Neuroimage Clin contributor: fullname: Kaye – volume: 168 start-page: 497 year: 1988 end-page: 505 article-title: Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging publication-title: Radiology contributor: fullname: Lallemand – volume: 120 start-page: 3395 year: 1994 end-page: 3403 article-title: Apoptosis during macrophage-dependent ocular tissue remodelling publication-title: Development contributor: fullname: Francois – volume: 21 start-page: 725 year: 2010 end-page: 739 article-title: A review of string vessels or collapsed, empty basement membrane tubes publication-title: J Alzheimers Dis contributor: fullname: Brown – volume: 68 start-page: 877 year: 2013 end-page: 891 article-title: Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells publication-title: J Gerontol A Biol Sci Med Sci contributor: fullname: Sosnowska – volume: 42 start-page: 85 year: 2018 end-page: 91 article-title: Measuring cerebral hypoperfusion induced by hyperventilation challenge with intravoxel incoherent motion magnetic resonance imaging in healthy volunteers publication-title: J Comput Assist Tomogr contributor: fullname: Mejdoubi – volume: 73 start-page: 102 year: 2015 end-page: 116 article-title: Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the european consortium for ASL in dementia publication-title: Magn Reson Med contributor: fullname: Golay – volume: 15 start-page: 5 year: 2008 end-page: 19 article-title: Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide publication-title: Amyloid contributor: fullname: Brem – volume: 15 start-page: 840 year: 2019 end-page: 858 article-title: Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations publication-title: Alzheimers Dement contributor: fullname: Sourbron – volume: 5 start-page: e986 year: 2014 article-title: STAT1-mediated bim expression promotes the apoptosis of retinal pericytes under high glucose conditions publication-title: Cell Death Dis contributor: fullname: Gurel – volume: 28 start-page: 378 year: 1990 end-page: 383 article-title: Cerebral circulation and oxygen metabolism associated with subclinical periventricular hyperintensity as shown by magnetic resonance imaging publication-title: Ann Neurol contributor: fullname: Yamaguchi – volume: 68 start-page: 409 year: 2010 end-page: 427 article-title: Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging publication-title: Neuron contributor: fullname: Sagare – volume: 61 start-page: 1437 year: 2019 end-page: 1445 article-title: Impact of hypertension on cerebral microvascular structure in CPAP-treated obstructive sleep apnoea patients: a diffusion magnetic resonance imaging study publication-title: Neuroradiology contributor: fullname: Lettau – volume: 53 start-page: 299 year: 1981 end-page: 318 article-title: Morphometric comparison of hippocampal microvasculature in ageing and demented people: diameters and densities publication-title: Acta Neuropathol contributor: fullname: Ball – volume: 50 start-page: 107 year: 2017 end-page: 118 article-title: Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study publication-title: Neurobiol Aging contributor: fullname: Nagenthiraja – volume: 54 start-page: 2409 year: 2011 end-page: 2416 article-title: Retinal vascular tortuosity in persons with diabetes and diabetic retinopathy publication-title: Diabetologia contributor: fullname: Nguyen – volume: 592 start-page: 3325 year: 2014 end-page: 3338 article-title: Effects of detraining on the temporal expression of positive and negative angioregulatory proteins in skeletal muscle of mice publication-title: J Physiol contributor: fullname: Roberts – volume: 26 start-page: 913 year: 2013 end-page: 931 article-title: The 39 steps: evading error and deciphering the secrets for accurate dynamic susceptibility contrast MRI publication-title: NMR Biomed contributor: fullname: Calamante – volume: 26 start-page: 307 year: 2006 end-page: 312 article-title: Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer's disease and vascular dementia publication-title: Neuropathology contributor: fullname: Di Rosa – volume: 12 start-page: 822 year: 2013 end-page: 838 article-title: Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration publication-title: Lancet Neurol contributor: fullname: Biessels – volume: 32 start-page: 264 year: 2012 end-page: 277 article-title: The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism publication-title: J Cereb Blood Flow Metab contributor: fullname: Østergaard – volume: 30 start-page: 1 year: 1985 end-page: 9 article-title: Rarefication of the arterioles and capillary network in the brain of rats with different forms of hypertension publication-title: Microvasc Res contributor: fullname: Blinkov – volume: 25 start-page: 283 year: 2004 end-page: 290 article-title: Co-accumulation of vascular endothelial growth factor with beta-amyloid in the brain of patients with Alzheimer's disease publication-title: Neurobiol Aging contributor: fullname: Kang – volume: 12 start-page: 8 year: 2003 end-page: 16 article-title: Pathologic evidence of microvascular rarefaction in the brain of renal hypertensive rats publication-title: J Stroke Cerebrovasc Dis contributor: fullname: Sakata – volume: 233 start-page: 883 year: 2004 end-page: 890 article-title: Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis publication-title: Radiology contributor: fullname: Anstrom – volume: 74 start-page: 1383 year: 2019 end-page: 1390 article-title: Associations of retinal microvascular diameters and tortuosity with blood pressure and arterial stiffness: United Kingdom biobank publication-title: Hypertension contributor: fullname: Barman – volume: 20 start-page: 297 year: 2011 end-page: 305 article-title: Mechanisms of fibrosis: the role of the pericyte publication-title: Curr Opin Nephrol Hypertens contributor: fullname: Duffield – volume: 468 start-page: 557 year: 2010 end-page: 561 article-title: Pericytes regulate the blood-brain barrier publication-title: Nature contributor: fullname: Mäe – volume: 51 start-page: 247 year: 2014 end-page: 258 article-title: The role of pericyte detachment in vascular rarefaction publication-title: J Vasc Res contributor: fullname: Wilhelmi – volume: 26 start-page: 573 year: 2004 end-page: 578 article-title: The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease publication-title: Neurol Res contributor: fullname: Rocher – volume: 14 start-page: 1412 year: 2013 end-page: 1427 article-title: Shear stress inhibits apoptosis of ischemic brain microvascular endothelial cells publication-title: Int J Mol Sci contributor: fullname: Yang – volume: 7 start-page: 321 year: 1986 end-page: 330 article-title: Quantitative changes in cerebral cortical microvasculature in ageing and dementia publication-title: Neurobiol Aging contributor: fullname: Marcyniuk – volume: 13 start-page: 456 year: 1986 end-page: 461 article-title: The correlation of vascular capacity with the parenchymal lesions of Alzheimer's disease publication-title: Can J Neurol Sci contributor: fullname: Ball – volume: 6 start-page: 379 year: 2004 end-page: 383 article-title: Increase of white matter string vessels in Alzheimer's disease. publication-title: J Alzheimers Dis contributor: fullname: Moody – volume: 12 start-page: 243 year: 2010 end-page: 251 article-title: Hypertension management and microvascular insulin resistance in diabetes publication-title: Curr Hypertens Rep contributor: fullname: Liu – volume: 42 start-page: 1183 year: 2020 end-page: 1193 article-title: Increase in blood-brain barrier leakage in healthy, older adults publication-title: Geroscience contributor: fullname: van Boxtel – volume: 59 start-page: 321 year: 2002 end-page: 326 article-title: Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis publication-title: Neurology contributor: fullname: Pereira – volume: 241 start-page: H306 year: 1981 end-page: 310 article-title: Microvascular rarefaction in spontaneously hypertensive rat cremaster muscle publication-title: Am J Physiol contributor: fullname: Dowell – volume: 36 start-page: 1653 year: 2016 end-page: 1667 article-title: Cerebral blood flow in small vessel disease: a systematic review and Meta-analysis publication-title: J Cereb Blood Flow Metab contributor: fullname: Makin – volume: 305 start-page: H1698 year: 2013 end-page: 1708 article-title: Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice publication-title: Am J Physiol Heart Circ Physiol contributor: fullname: Tucsek – volume: 51 start-page: 1170 year: 2020 end-page: 1180 article-title: Spectral diffusion analysis of intravoxel incoherent motion MRI in cerebral small vessel disease publication-title: J Magn Reson Imaging contributor: fullname: Drenthen – volume: 15 start-page: 554 year: 2014 end-page: 577 article-title: Perfusion magnetic resonance imaging: a comprehensive update on principles and techniques publication-title: Korean J Radiol contributor: fullname: Ostergaard – volume: 42 start-page: 2672 year: 2011 end-page: 2713 article-title: Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association publication-title: Stroke contributor: fullname: Black – volume: 281 start-page: 337 year: 2016 end-page: 356 article-title: Arterial spin labeling perfusion of the brain: Emerging clinical applications publication-title: Radiology contributor: fullname: Thomas – volume: 12 start-page: 643468 year: 2021 article-title: Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review publication-title: Front Physiol contributor: fullname: Marshall – volume: 21 start-page: 193 year: 2011 end-page: 215 article-title: Pericytes: developmental, physiological, and pathological perspectives, problems, and promises publication-title: Dev Cell contributor: fullname: Betsholtz – volume: 72 start-page: 168 year: 2017 end-page: 175 article-title: Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease publication-title: Neurosci Biobehav Rev contributor: fullname: Goldberg – volume: 332 start-page: 1119 year: 2006 end-page: 1124 article-title: Cerebral emboli as a potential cause of Alzheimer's disease and vascular dementia: case-control study publication-title: Bmj contributor: fullname: Daly – volume: 65 start-page: 1028 year: 2010 end-page: 1041 article-title: Mechanisms of vascular aging: new perspectives publication-title: J Gerontol A Biol Sci Med Sci contributor: fullname: de Cabo – volume: 92 start-page: e1669 year: 2019 end-page: e1677 article-title: Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease publication-title: Neurology contributor: fullname: Zhang – volume: 85 start-page: 113 year: 2020 end-page: 122 article-title: White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed publication-title: Neurobiol Aging contributor: fullname: de Jong – volume: 26 start-page: 1004 year: 2013 end-page: 1027 article-title: Classic models for dynamic contrast-enhanced MRI publication-title: NMR Biomed contributor: fullname: Buckley – volume: 8 start-page: 129 year: 2001 end-page: 139 article-title: Microvascular endothelial cell death and rarefaction in the glucocorticoid-induced hypertensive rat publication-title: Microcirculation contributor: fullname: Schmid-Schonbein – volume: 23 start-page: 237 year: 2002 end-page: 243 article-title: Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia publication-title: Neurobiol Aging contributor: fullname: Sjögren – volume: 53 start-page: 553 year: 2005 end-page: 563 article-title: Vessel size imaging in humans publication-title: Magn Reson Med contributor: fullname: Ziyeh – volume: 171 start-page: 1989 year: 2007 end-page: 1999 article-title: Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells publication-title: Am J Pathol contributor: fullname: van Triel – volume: 11 start-page: 359 year: 1990 end-page: 370 article-title: Neuritic plaques and vessels of visual cortex in aging and Alzheimer's dementia publication-title: Neurobiol Aging contributor: fullname: Ball – year: 2018 article-title: The age-related perfusion pattern measured with arterial spin labeling MRI in healthy subjects publication-title: Front Aging Neurosci contributor: fullname: Ma – volume: 120 start-page: 433 year: 2010 end-page: 445 article-title: Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease publication-title: J Clin Invest contributor: fullname: Gosele – volume: 23 start-page: 1673 year: 1992 end-page: 1677 article-title: Leukoaraiosis and dementia in hypertensive patients publication-title: Stroke contributor: fullname: Ibayashi – volume: 281 start-page: 527 year: 2016 end-page: 535 article-title: Blood-Brain barrier leakage in patients with early Alzheimer disease publication-title: Radiology contributor: fullname: Jansen – volume: 101 start-page: 9833 year: 2004 end-page: 9838 article-title: Insulin-like growth factor I is required for vessel remodeling in the adult brain publication-title: Proc Natl Acad Sci U S A contributor: fullname: Torres-Aleman – volume: 63 start-page: 5950 year: 2003 end-page: 5956 article-title: Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation publication-title: Cancer Res contributor: fullname: Haimovitz-Friedman – volume: 106 start-page: 257 year: 2021 end-page: 267 article-title: Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample publication-title: Neurobiology of Aging contributor: fullname: Verheggen – volume: 87 start-page: 469 year: 1994 end-page: 480 article-title: Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders publication-title: Acta Neuropathol contributor: fullname: Bouras – volume: 1 start-page: 4 year: 2009 article-title: Resveratrol preserves cerebrovascular density and cognitive function in aging mice publication-title: Front Aging Neurosci contributor: fullname: Roman – volume: 88 start-page: 426 year: 2017 end-page: 432 article-title: Blood-brain barrier leakage is more widespread in patients with cerebral small vessel disease publication-title: Neurology contributor: fullname: van de Haar – volume: 107 start-page: 603 year: 2001 end-page: 613 article-title: Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis publication-title: Neuroscience contributor: fullname: Bennett – volume: 172 start-page: 117 year: 2009 end-page: 120 article-title: Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging publication-title: Psychiatry Res contributor: fullname: Muraskin – year: 2020 article-title: Changes in microvascular morphology in subcortical vascular dementia: a study of vessel size magnetic resonance imaging publication-title: Front Neurol contributor: fullname: Kim – volume: 18 start-page: 265 year: 2015 end-page: 281 article-title: Cardiovascular risk factors cause premature rarefaction of the collateral circulation and greater ischemic tissue injury publication-title: Angiogenesis contributor: fullname: Maeda – volume: 7 start-page: e30444 year: 2012 article-title: Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia publication-title: PLoS One contributor: fullname: Mitschelen – volume: 84 start-page: 606 year: 1992 end-page: 612 article-title: Expression of leukocyte antigen CD34 by brain capillaries in Alzheimer's disease and neurologically normal subjects publication-title: Acta Neuropathol contributor: fullname: Kroon – volume: 161 start-page: 401 year: 1986 end-page: 407 article-title: MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders publication-title: Radiology contributor: fullname: Lallemand – ident: bibr87-0271678X221076557 doi: 10.1016/0197-4580(86)90158-2 – ident: bibr113-0271678X221076557 doi: 10.1113/JP277425 – volume: 63 start-page: 5950 year: 2003 ident: bibr92-0271678X221076557 publication-title: Cancer Res contributor: fullname: Li YQ – ident: bibr53-0271678X221076557 doi: 10.1097/nen.0b013e3180537147 – ident: bibr148-0271678X221076557 doi: 10.3348/kjr.2014.15.5.554 – ident: bibr37-0271678X221076557 doi: 10.1038/s41569-018-0030-z – ident: bibr81-0271678X221076557 doi: 10.1016/0197-4580(90)90001-G – ident: bibr91-0271678X221076557 doi: 10.1371/journal.pone.0030444 – ident: bibr32-0271678X221076557 doi: 10.1097/HJH.0000000000000021 – ident: bibr22-0271678X221076557 doi: 10.1113/jphysiol.2014.271213 – ident: bibr4-0271678X221076557 doi: 10.1038/nrn3114 – ident: bibr12-0271678X221076557 doi: 10.1038/ncomms15557 – ident: bibr100-0271678X221076557 doi: 10.1002/mrm.25396 – volume: 141 start-page: 249 year: 1992 ident: bibr73-0271678X221076557 publication-title: Am J Pathol contributor: fullname: Yamaguchi H – ident: bibr78-0271678X221076557 doi: 10.1016/S0197-4580(03)00111-8 – ident: bibr147-0271678X221076557 doi: 10.1038/s41598-018-26475-5 – ident: bibr90-0271678X221076557 doi: 10.1667/RR3453.1 – ident: bibr109-0271678X221076557 doi: 10.1002/jmri.24864 – ident: bibr103-0271678X221076557 doi: 10.1016/j.jalz.2010.04.004 – ident: bibr24-0271678X221076557 doi: 10.1016/S0197-4580(01)00285-8 – ident: bibr26-0271678X221076557 doi: 10.1007/BF00294173 – ident: bibr116-0271678X221076557 doi: 10.1148/radiol.2016152244 – ident: bibr141-0271678X221076557 doi: 10.1016/j.nicl.2018.08.030 – ident: bibr49-0271678X221076557 doi: 10.1016/j.devcel.2011.07.001 – ident: bibr108-0271678X221076557 doi: 10.1038/s41598-018-37564-w – ident: bibr127-0271678X221076557 doi: 10.1016/j.pscychresns.2008.11.006 – ident: bibr144-0271678X221076557 doi: 10.1002/jmri.26920 – ident: bibr82-0271678X221076557 doi: 10.1007/BF00294246 – ident: bibr80-0271678X221076557 doi: 10.1007/BF00690372 – ident: bibr85-0271678X221076557 doi: 10.3233/JAD-2010-100219 – ident: bibr98-0271678X221076557 doi: 10.1007/s10334-009-0190-2 – ident: bibr62-0271678X221076557 doi: 10.1016/j.jns.2007.01.015 – ident: bibr65-0271678X221076557 doi: 10.1152/ajpheart.00377.2013 – ident: bibr63-0271678X221076557 doi: 10.1148/radiol.2333020981 – ident: bibr84-0271678X221076557 doi: 10.1179/016164104225016272 – ident: bibr50-0271678X221076557 doi: 10.1038/nature09522 – ident: bibr133-0271678X221076557 doi: 10.1002/mrm.1910270116 – ident: bibr29-0271678X221076557 doi: 10.1016/0361-9230(90)90007-M – ident: bibr57-0271678X221076557 doi: 10.1073/pnas.0905891106 – ident: bibr21-0271678X221076557 doi: 10.1111/micc.12263 – ident: bibr120-0271678X221076557 doi: 10.1002/mrm.25197 – ident: bibr46-0271678X221076557 doi: 10.1038/cddis.2013.517 – ident: bibr44-0271678X221076557 doi: 10.1097/MNH.0b013e328344c3d4 – ident: bibr15-0271678X221076557 doi: 10.1073/pnas.0400337101 – ident: bibr117-0271678X221076557 doi: 10.1007/s11357-020-00211-2 – ident: bibr43-0271678X221076557 doi: 10.1038/jcbfm.2011.153 – ident: bibr6-0271678X221076557 doi: 10.1111/j.1365-2990.2010.01139.x – ident: bibr40-0271678X221076557 doi: 10.3390/ijms18091897 – ident: bibr38-0271678X221076557 doi: 10.1016/j.yexcr.2007.07.023 – ident: bibr99-0271678X221076557 doi: 10.1002/nbm.2833 – ident: bibr86-0271678X221076557 doi: 10.1006/exnr.1993.1095 – ident: bibr76-0271678X221076557 doi: 10.1016/j.bbadis.2013.08.007 – ident: bibr13-0271678X221076557 doi: 10.1210/endo.138.8.5330 – ident: bibr18-0271678X221076557 doi: 10.1093/gerona/glu080 – ident: bibr23-0271678X221076557 doi: 10.1038/jcbfm.2014.226 – ident: bibr89-0271678X221076557 doi: 10.1152/ajpheart.01024.2010 – ident: bibr10-0271678X221076557 doi: 10.1111/apha.12250 – ident: bibr60-0271678X221076557 doi: 10.1016/j.neuron.2013.10.008 – ident: bibr146-0271678X221076557 doi: 10.1097/MD.0000000000004206 – ident: bibr145-0271678X221076557 doi: 10.1177/0271678X16662891 – ident: bibr104-0271678X221076557 doi: 10.1016/j.acra.2013.01.020 – ident: bibr2-0271678X221076557 doi: 10.1371/journal.pone.0038692 – ident: bibr14-0271678X221076557 doi: 10.1016/S0306-4522(01)00378-5 – ident: bibr31-0271678X221076557 doi: 10.1016/j.jns.2009.02.328 – ident: bibr39-0271678X221076557 doi: 10.3389/neuro.24.004.2009 – ident: bibr59-0271678X221076557 doi: 10.1038/kisup.2014.9 – ident: bibr42-0271678X221076557 doi: 10.1111/acel.12731 – ident: bibr137-0271678X221076557 doi: 10.2337/dc14-2043 – ident: bibr36-0271678X221076557 doi: 10.3390/ijms14011412 – ident: bibr132-0271678X221076557 doi: 10.1148/radiology.168.2.3393671 – ident: bibr30-0271678X221076557 doi: 10.1007/BF00227737 – ident: bibr131-0271678X221076557 doi: 10.1148/radiology.161.2.3763909 – ident: bibr114-0271678X221076557 doi: 10.1212/WNL.0000000000003556 – ident: bibr75-0271678X221076557 doi: 10.2353/ajpath.2007.070050 – ident: bibr77-0271678X221076557 doi: 10.1080/13506120701814723 – ident: bibr83-0271678X221076557 doi: 10.1161/01.STR.0000024523.82311.77 – start-page: 71 year: 1990 ident: bibr8-0271678X221076557 publication-title: Blood Vessel Changes Hypertens: Struct Func contributor: fullname: Prewitt R. – ident: bibr97-0271678X221076557 doi: 10.1212/WNL.59.3.321 – ident: bibr123-0271678X221076557 doi: 10.1016/j.pnmrs.2019.09.002 – ident: bibr101-0271678X221076557 doi: 10.1002/1522-2586(200009)12:3<381::AID-JMRI2>3.0.CO;2-Y – ident: bibr111-0271678X221076557 doi: 10.1002/nbm.2940 – ident: bibr140-0271678X221076557 doi: 10.1016/j.neuroimage.2019.116228 – ident: bibr51-0271678X221076557 doi: 10.1016/j.neuron.2010.09.043 – year: 2018 ident: bibr129-0271678X221076557 publication-title: Front Aging Neurosci contributor: fullname: Zhang N – ident: bibr125-0271678X221076557 doi: 10.1016/j.neubiorev.2016.11.023 – ident: bibr112-0271678X221076557 doi: 10.1016/j.jalz.2019.01.013 – ident: bibr55-0271678X221076557 doi: 10.1007/s00125-011-2200-y – ident: bibr48-0271678X221076557 doi: 10.1038/kisup.2014.20 – ident: bibr79-0271678X221076557 doi: 10.1017/S0317167100037124 – ident: bibr102-0271678X221076557 doi: 10.1016/j.neurobiolaging.2016.11.004 – ident: bibr119-0271678X221076557 doi: 10.1007/s00234-015-1571-z – ident: bibr72-0271678X221076557 doi: 10.1073/pnas.90.22.10836 – ident: bibr115-0271678X221076557 doi: 10.1016/j.neurobiolaging.2019.09.017 – ident: bibr17-0271678X221076557 doi: 10.1093/gerona/gls242 – ident: bibr67-0271678X221076557 doi: 10.1007/s10456-015-9465-6 – ident: bibr34-0271678X221076557 doi: 10.1080/713774024 – ident: bibr94-0271678X221076557 doi: 10.1002/ana.410280313 – ident: bibr121-0271678X221076557 doi: 10.1002/mrm.22002 – ident: bibr128-0271678X221076557 doi: 10.1016/j.nicl.2015.04.012 – ident: bibr106-0271678X221076557 doi: 10.1212/WNL.0000000000007263 – ident: bibr107-0271678X221076557 doi: 10.1002/mrm.20383 – ident: bibr149-0271678X221076557 – ident: bibr66-0271678X221076557 doi: 10.1093/gerona/glt177 – ident: bibr122-0271678X221076557 doi: 10.1177/0271678X17713434 – ident: bibr68-0271678X221076557 doi: 10.1053/jscd.2003.1 – ident: bibr124-0271678X221076557 doi: 10.3389/fphys.2021.643468 – ident: bibr143-0271678X221076557 doi: 10.1097/RLI.0000000000000723 – ident: bibr64-0271678X221076557 doi: 10.1172/JCI39733 – ident: bibr33-0271678X221076557 doi: 10.1111/j.1752-8062.2008.00016.x – ident: bibr16-0271678X221076557 doi: 10.1007/s11357-016-9931-0 – ident: bibr25-0271678X221076557 doi: 10.1111/j.1440-1789.2006.00701.x – ident: bibr35-0271678X221076557 doi: 10.1007/s11906-010-0114-6 – ident: bibr52-0271678X221076557 doi: 10.1016/j.jns.2012.07.010 – ident: bibr142-0271678X221076557 doi: 10.1007/s00234-019-02292-z – volume: 241 start-page: H306 year: 1981 ident: bibr7-0271678X221076557 publication-title: Am J Physiol contributor: fullname: Chen II – ident: bibr41-0271678X221076557 doi: 10.1016/j.redox.2019.101192 – ident: bibr105-0271678X221076557 doi: 10.1016/j.jstrokecerebrovasdis.2017.03.002 – ident: bibr27-0271678X221076557 doi: 10.3233/JAD-2004-6404 – ident: bibr1-0271678X221076557 doi: 10.1152/japplphysiol.00966.2005 – ident: bibr95-0271678X221076557 doi: 10.1001/archneur.1991.00530220089024 – ident: bibr126-0271678X221076557 doi: 10.1016/j.nicl.2019.102146 – ident: bibr3-0271678X221076557 doi: 10.1016/S1474-4422(19)30079-1 – ident: bibr74-0271678X221076557 doi: 10.1161/HYPERTENSIONAHA.113.01063 – ident: bibr56-0271678X221076557 doi: 10.1136/bmj.38814.696493.AE – ident: bibr135-0271678X221076557 doi: 10.1097/RCT.0000000000000640 – ident: bibr47-0271678X221076557 doi: 10.1159/000365149 – volume: 17 start-page: 206 year: 2010 ident: bibr19-0271678X221076557 publication-title: Curr Opin Hematol contributor: fullname: Sung HK – ident: bibr54-0271678X221076557 doi: 10.1161/HYPERTENSIONAHA.119.13752 – ident: bibr139-0271678X221076557 doi: 10.1016/j.neurobiolaging.2021.06.017 – ident: bibr110-0271678X221076557 doi: 10.3389/fneur.2020.545450 – ident: bibr69-0271678X221076557 doi: 10.1016/0026-2862(85)90032-9 – ident: bibr130-0271678X221076557 doi: 10.1097/MD.0000000000020463 – ident: bibr134-0271678X221076557 doi: 10.1016/j.nicl.2017.01.017 – ident: bibr28-0271678X221076557 doi: 10.1097/00001756-199502000-00018 – ident: bibr61-0271678X221076557 doi: 10.1016/S1474-4422(13)70124-8 – ident: bibr138-0271678X221076557 doi: 10.1002/jmri.27272 – ident: bibr45-0271678X221076557 doi: 10.2353/ajpath.2008.080433 – ident: bibr71-0271678X221076557 doi: 10.1161/STR.0b013e3182299496 – ident: bibr93-0271678X221076557 doi: 10.1152/ajpheart.00308.2014 – ident: bibr118-0271678X221076557 doi: 10.1148/radiol.2016150789 – ident: bibr11-0271678X221076557 doi: 10.1093/gerona/glq113 – ident: bibr70-0271678X221076557 doi: 10.1161/01.HYP.6.3.408 – ident: bibr136-0271678X221076557 doi: 10.1201/9780429427275-4 – ident: bibr88-0271678X221076557 doi: 10.1016/j.ijrobp.2007.09.059 – ident: bibr96-0271678X221076557 doi: 10.1161/01.STR.23.11.1673 – ident: bibr20-0271678X221076557 doi: 10.1016/j.devcel.2015.06.004 – ident: bibr9-0271678X221076557 doi: 10.1007/s11357-019-00139-2 – ident: bibr58-0271678X221076557 doi: 10.1242/dev.120.12.3395 – ident: bibr5-0271678X221076557 doi: 10.4161/org.6.1.10427 |
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Snippet | Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role... Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role... |
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SubjectTerms | Blood-Brain Barrier - metabolism Brain - blood supply Brain - diagnostic imaging Brain Diseases - pathology Humans Magnetic Resonance Imaging Microvascular Rarefaction Review |
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Title | Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging |
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