Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging

Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role in the early stages of microvascular related brain disorders. A better understanding of its underlying pathophysiological mechanisms, and met...

Full description

Saved in:
Bibliographic Details
Published inJournal of Cerebral Blood Flow & Metabolism Vol. 42; no. 5; pp. 718 - 737
Main Authors van Dinther, Maud, Voorter, Paulien HM, Jansen, Jacobus FA, Jones, Elizabeth AV, van Oostenbrugge, Robert J, Staals, Julie, Backes, Walter H
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.05.2022
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role in the early stages of microvascular related brain disorders. A better understanding of its underlying pathophysiological mechanisms, and methods to measure microvascular density in the human brain are needed to develop biomarkers for early diagnosis and to identify targets for disease modifying treatments. Therefore, we provide an overview of the assumed main pathophysiological processes underlying cerebral microvascular rarefaction and the evidence for rarefaction in several microvascular related brain disorders. A number of advanced physiological MRI techniques can be used to measure the pathological alterations associated with microvascular rarefaction. Although more research is needed to explore and validate these MRI techniques in microvascular rarefaction in brain disorders, they provide a set of promising future tools to assess various features relevant for rarefaction, such as cerebral blood flow and volume, vessel density and radius and blood-brain barrier leakage.
AbstractList Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role in the early stages of microvascular related brain disorders. A better understanding of its underlying pathophysiological mechanisms, and methods to measure microvascular density in the human brain are needed to develop biomarkers for early diagnosis and to identify targets for disease modifying treatments. Therefore, we provide an overview of the assumed main pathophysiological processes underlying cerebral microvascular rarefaction and the evidence for rarefaction in several microvascular related brain disorders. A number of advanced physiological MRI techniques can be used to measure the pathological alterations associated with microvascular rarefaction. Although more research is needed to explore and validate these MRI techniques in microvascular rarefaction in brain disorders, they provide a set of promising future tools to assess various features relevant for rarefaction, such as cerebral blood flow and volume, vessel density and radius and blood-brain barrier leakage.
Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role in the early stages of microvascular related brain disorders. A better understanding of its underlying pathophysiological mechanisms, and methods to measure microvascular density in the human brain are needed to develop biomarkers for early diagnosis and to identify targets for disease modifying treatments. Therefore, we provide an overview of the assumed main pathophysiological processes underlying cerebral microvascular rarefaction and the evidence for rarefaction in several microvascular related brain disorders. A number of advanced physiological MRI techniques can be used to measure the pathological alterations associated with microvascular rarefaction. Although more research is needed to explore and validate these MRI techniques in microvascular rarefaction in brain disorders, they provide a set of promising future tools to assess various features relevant for rarefaction, such as cerebral blood flow and volume, vessel density and radius and blood-brain barrier leakage.
Author Staals, Julie
Jansen, Jacobus FA
Jones, Elizabeth AV
Backes, Walter H
van Dinther, Maud
Voorter, Paulien HM
van Oostenbrugge, Robert J
Author_xml – sequence: 1
  givenname: Maud
  orcidid: 0000-0001-7349-4783
  surname: van Dinther
  fullname: van Dinther, Maud
  organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
– sequence: 2
  givenname: Paulien HM
  surname: Voorter
  fullname: Voorter, Paulien HM
  organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
– sequence: 3
  givenname: Jacobus FA
  surname: Jansen
  fullname: Jansen, Jacobus FA
  organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
– sequence: 4
  givenname: Elizabeth AV
  surname: Jones
  fullname: Jones, Elizabeth AV
  organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
– sequence: 5
  givenname: Robert J
  surname: van Oostenbrugge
  fullname: van Oostenbrugge, Robert J
  organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
– sequence: 6
  givenname: Julie
  surname: Staals
  fullname: Staals, Julie
  organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
– sequence: 7
  givenname: Walter H
  surname: Backes
  fullname: Backes, Walter H
  organization: Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35078344$$D View this record in MEDLINE/PubMed
BookMark eNp9kU9r3DAQxUVJaTZpP0AuRcdcnEqyZVmXQAj9Ewj00kBuYizJXgVb2mrsQL59tWwaUgo5SWh-82b03gk5iil6Qs44u-BcqS9MKN6q7l4IzlQrpXpHNlxKXSnG2yOy2derPXBMThAfGGNdLeUHclxLprq6aTYkXSF6xNnHhaaBzsHm9Aho1wkyzZD9AHYJKdIQ6XadIdI-Q7m7gCk7n5GuGOJId9snDGlKY7Aw0RnG6JdgafaYIkTraShvBfxI3g8wof_0fJ6Su29ff13_qG5_fr-5vrqtbFN3S8W5FAwakEPrey26wXLHOg5CN4I7C9p1ztpeae2dkrxXXMlmcLplzA8SRH1KLg-6u7WfvbPlfxkms8tlj_xkEgTzbyWGrRnTo9GMN22nisD5s0BOv1ePi5kDWj9NEH1a0YhWCC2Liayg_IAW7xCLZS9jODP7oMx_QZWez6_3e-n4m0wBLg4AwujNQ1pzLH69ofgH1iqhbA
CitedBy_id crossref_primary_10_1007_s40477_023_00867_4
crossref_primary_10_1016_j_jbc_2023_105221
crossref_primary_10_1161_HYPERTENSIONAHA_123_19939
crossref_primary_10_3389_fncel_2022_876746
crossref_primary_10_3390_medicina59091596
crossref_primary_10_1016_j_vph_2024_107393
crossref_primary_10_3390_medicina59071337
crossref_primary_10_1016_j_biopsych_2023_07_023
crossref_primary_10_1016_j_exger_2024_112510
crossref_primary_10_1016_j_bpsc_2024_03_005
crossref_primary_10_1007_s11357_023_00748_y
crossref_primary_10_1162_imag_a_00066
crossref_primary_10_1159_000529067
Cites_doi 10.1016/0197-4580(86)90158-2
10.1113/JP277425
10.1097/nen.0b013e3180537147
10.3348/kjr.2014.15.5.554
10.1038/s41569-018-0030-z
10.1016/0197-4580(90)90001-G
10.1371/journal.pone.0030444
10.1097/HJH.0000000000000021
10.1113/jphysiol.2014.271213
10.1038/nrn3114
10.1038/ncomms15557
10.1002/mrm.25396
10.1016/S0197-4580(03)00111-8
10.1038/s41598-018-26475-5
10.1667/RR3453.1
10.1002/jmri.24864
10.1016/j.jalz.2010.04.004
10.1016/S0197-4580(01)00285-8
10.1007/BF00294173
10.1148/radiol.2016152244
10.1016/j.nicl.2018.08.030
10.1016/j.devcel.2011.07.001
10.1038/s41598-018-37564-w
10.1016/j.pscychresns.2008.11.006
10.1002/jmri.26920
10.1007/BF00294246
10.1007/BF00690372
10.3233/JAD-2010-100219
10.1007/s10334-009-0190-2
10.1016/j.jns.2007.01.015
10.1152/ajpheart.00377.2013
10.1148/radiol.2333020981
10.1179/016164104225016272
10.1038/nature09522
10.1002/mrm.1910270116
10.1016/0361-9230(90)90007-M
10.1073/pnas.0905891106
10.1111/micc.12263
10.1002/mrm.25197
10.1038/cddis.2013.517
10.1097/MNH.0b013e328344c3d4
10.1073/pnas.0400337101
10.1007/s11357-020-00211-2
10.1038/jcbfm.2011.153
10.1111/j.1365-2990.2010.01139.x
10.3390/ijms18091897
10.1016/j.yexcr.2007.07.023
10.1002/nbm.2833
10.1006/exnr.1993.1095
10.1016/j.bbadis.2013.08.007
10.1210/endo.138.8.5330
10.1093/gerona/glu080
10.1038/jcbfm.2014.226
10.1152/ajpheart.01024.2010
10.1111/apha.12250
10.1016/j.neuron.2013.10.008
10.1097/MD.0000000000004206
10.1177/0271678X16662891
10.1016/j.acra.2013.01.020
10.1371/journal.pone.0038692
10.1016/S0306-4522(01)00378-5
10.1016/j.jns.2009.02.328
10.3389/neuro.24.004.2009
10.1038/kisup.2014.9
10.1111/acel.12731
10.2337/dc14-2043
10.3390/ijms14011412
10.1148/radiology.168.2.3393671
10.1007/BF00227737
10.1148/radiology.161.2.3763909
10.1212/WNL.0000000000003556
10.2353/ajpath.2007.070050
10.1080/13506120701814723
10.1161/01.STR.0000024523.82311.77
10.1212/WNL.59.3.321
10.1016/j.pnmrs.2019.09.002
10.1002/1522-2586(200009)12:3<381::AID-JMRI2>3.0.CO;2-Y
10.1002/nbm.2940
10.1016/j.neuroimage.2019.116228
10.1016/j.neuron.2010.09.043
10.1016/j.neubiorev.2016.11.023
10.1016/j.jalz.2019.01.013
10.1007/s00125-011-2200-y
10.1038/kisup.2014.20
10.1017/S0317167100037124
10.1016/j.neurobiolaging.2016.11.004
10.1007/s00234-015-1571-z
10.1073/pnas.90.22.10836
10.1016/j.neurobiolaging.2019.09.017
10.1093/gerona/gls242
10.1007/s10456-015-9465-6
10.1080/713774024
10.1002/ana.410280313
10.1002/mrm.22002
10.1016/j.nicl.2015.04.012
10.1212/WNL.0000000000007263
10.1002/mrm.20383
10.1093/gerona/glt177
10.1177/0271678X17713434
10.1053/jscd.2003.1
10.3389/fphys.2021.643468
10.1097/RLI.0000000000000723
10.1172/JCI39733
10.1111/j.1752-8062.2008.00016.x
10.1007/s11357-016-9931-0
10.1111/j.1440-1789.2006.00701.x
10.1007/s11906-010-0114-6
10.1016/j.jns.2012.07.010
10.1007/s00234-019-02292-z
10.1016/j.redox.2019.101192
10.1016/j.jstrokecerebrovasdis.2017.03.002
10.3233/JAD-2004-6404
10.1152/japplphysiol.00966.2005
10.1001/archneur.1991.00530220089024
10.1016/j.nicl.2019.102146
10.1016/S1474-4422(19)30079-1
10.1161/HYPERTENSIONAHA.113.01063
10.1136/bmj.38814.696493.AE
10.1097/RCT.0000000000000640
10.1159/000365149
10.1161/HYPERTENSIONAHA.119.13752
10.1016/j.neurobiolaging.2021.06.017
10.3389/fneur.2020.545450
10.1016/0026-2862(85)90032-9
10.1097/MD.0000000000020463
10.1016/j.nicl.2017.01.017
10.1097/00001756-199502000-00018
10.1016/S1474-4422(13)70124-8
10.1002/jmri.27272
10.2353/ajpath.2008.080433
10.1161/STR.0b013e3182299496
10.1152/ajpheart.00308.2014
10.1148/radiol.2016150789
10.1093/gerona/glq113
10.1161/01.HYP.6.3.408
10.1201/9780429427275-4
10.1016/j.ijrobp.2007.09.059
10.1161/01.STR.23.11.1673
10.1016/j.devcel.2015.06.004
10.1007/s11357-019-00139-2
10.1242/dev.120.12.3395
10.4161/org.6.1.10427
ContentType Book Review
Journal Article
Copyright The Author(s) 2022
The Author(s) 2022 2022 International Society for Cerebral Blood Flow and Metabolism
Copyright_xml – notice: The Author(s) 2022
– notice: The Author(s) 2022 2022 International Society for Cerebral Blood Flow and Metabolism
DBID AFRWT
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1177/0271678X221076557
DatabaseName Sage Journals GOLD Open Access 2024
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList CrossRef

MEDLINE

Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: AFRWT
  name: Sage Journals GOLD Open Access 2024
  url: http://journals.sagepub.com/
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
EISSN 1559-7016
EndPage 737
ExternalDocumentID 10_1177_0271678X221076557
35078344
10.1177_0271678X221076557
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-Q-
-TM
.55
.GJ
0R~
29K
2WC
36B
39C
3O-
3V.
4.4
53G
54M
5GY
5RE
5VS
70F
7X7
88A
88E
8AO
8FE
8FH
8FI
8FJ
8R4
8R5
AABMB
AACKU
AACMV
AADUE
AAEWN
AAGGD
AAGMC
AAJIQ
AAJPV
AAKGS
AAMGE
AANSI
AAPEO
AAQGT
AAQXH
AARDL
AARIX
AATAA
AATBZ
AAUAS
AAVDI
AAXOT
AAYTG
AAZBJ
ABAWP
ABAWZ
ABCCA
ABDWY
ABEIX
ABFWQ
ABHKI
ABJNI
ABKRH
ABLUO
ABNCE
ABPGX
ABPNF
ABQKF
ABQNX
ABQXT
ABRHV
ABUWG
ABVFX
ABXGC
ABYTW
ACARO
ACDSZ
ACDXX
ACFEJ
ACFMA
ACGBL
ACGFO
ACGFS
ACGZU
ACJTF
ACLFY
ACLHI
ACNXM
ACOFE
ACOXC
ACPRK
ACROE
ACSIQ
ACTQU
ACUAV
ACUIR
ACXKE
ACXMB
ADBBV
ADEIA
ADMPF
ADRRZ
ADTBJ
ADUKL
ADZZY
AECGH
AENEX
AEPTA
AEQLS
AESZF
AEUHG
AEUIJ
AEWDL
AEWHI
AEXFG
AEXNY
AFEET
AFFNX
AFFZS
AFKRA
AFKRG
AFMOU
AFOSN
AFQAA
AFRWT
AFUIA
AGKLV
AGNHF
AGWFA
AHMBA
AIGRN
AIOMO
AJABX
AJEFB
AJMMQ
AJSCY
AJUZI
AJXAJ
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALTZF
AMCVQ
ANDLU
AOIJS
ARTOV
AUTPY
AYAKG
B8M
BAWUL
BBNVY
BBRGL
BDDNI
BENPR
BHPHI
BKIIM
BKSCU
BPACV
BPHCQ
BSEHC
BVXVI
BWJAD
C45
CAG
CBRKF
CCPQU
CDWPY
CFDXU
COF
CORYS
CQQTX
CS3
CUTAK
D-I
DC-
DC.
DIK
DOPDO
DV7
E3Z
EBS
EE.
EJD
EMOBN
F5P
FHBDP
FYUFA
GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION
GX1
HCIFZ
HMCUK
HYE
HZ~
J8X
JCYGO
JSO
K.F
KQ8
LK8
M0L
M1P
M4V
M7P
O9-
OK1
OVD
P2P
P6G
PQQKQ
PROAC
PSQYO
Q1R
Q2X
RNS
RNTTT
ROL
RPM
SCNPE
SFC
SHG
SPQ
SPV
TEORI
TR2
UKHRP
W2D
X7M
YFH
YOC
ZGI
ZONMY
ZPPRI
ZRKOI
ZSSAH
ZXP
ACJER
AFVCE
AJXGE
ALKWR
CGR
CUY
CVF
ECM
EIF
H13
NPM
AAYXX
CITATION
7X8
ADVBO
5PM
ID FETCH-LOGICAL-c438t-11520a4a5f6eb928fc1d081a29421dca9d8dccb799ed751b71754fd9600ef5a23
IEDL.DBID RPM
ISSN 0271-678X
IngestDate Tue Sep 17 21:27:59 EDT 2024
Fri Oct 25 11:12:50 EDT 2024
Wed Oct 09 16:48:24 EDT 2024
Wed Oct 16 00:41:09 EDT 2024
Tue Jul 16 20:45:58 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords cerebral small vessel disease
magnetic resonance imaging
Alzheimer’s disease
microvascular density
microvascular rarefaction
Language English
License This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c438t-11520a4a5f6eb928fc1d081a29421dca9d8dccb799ed751b71754fd9600ef5a23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
ORCID 0000-0001-7349-4783
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014687/
PMID 35078344
PQID 2622958340
PQPubID 23479
PageCount 20
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9014687
proquest_miscellaneous_2622958340
crossref_primary_10_1177_0271678X221076557
pubmed_primary_35078344
sage_journals_10_1177_0271678X221076557
PublicationCentury 2000
PublicationDate 2022-05-01
PublicationDateYYYYMMDD 2022-05-01
PublicationDate_xml – month: 05
  year: 2022
  text: 2022-05-01
  day: 01
PublicationDecade 2020
PublicationPlace London, England
PublicationPlace_xml – name: London, England
– name: United States
– name: Sage UK: London, England
PublicationTitle Journal of Cerebral Blood Flow & Metabolism
PublicationTitleAlternate J Cereb Blood Flow Metab
PublicationYear 2022
Publisher SAGE Publications
Publisher_xml – name: SAGE Publications
References García-Amado, Prensa 2012; 7
Ungvari, Tucsek, Sosnowska 2013; 68
Suzuki, Masawa, Sakata 2003; 12
Korn, Augustin 2015; 34
Zhang, Wong, van de Haar 2017; 88
Zlokovic 2011; 12
Iadecola 2013; 80
Le Bihan, Turner 1992; 27
Tong, Hamel 2015; 35
Sleight, Stringer, Marshall 2021; 12
Shin, Huang, Gurel 2014; 5
Willats, Calamante 2013; 26
Choi, Ryu, Kim 2020
Tarantini, Tucsek, Valcarcel-Ares 2016; 38
Yang, Bae, Kang 2004; 25
Brown 2010; 21
Elschot, Backes, Postma 2021; 56
van der Thiel, Freeze, Verheggen 2021; 106
Sasongko, Wong, Nguyen 2011; 54
Brown, Moody, Thore 2007; 257
Suter, Sunthorn, Kraftsik 2002; 33
Schrimpf, Duffield 2011; 20
Chen, Prewitt, Dowell 1981; 241
Chakhoyan, Yao, Leu 2019; 9
Brickman, Zahra, Muraskin 2009; 172
Le Bihan, Breton, Lallemand 1988; 168
Muoio, Persson, Sendeski 2014; 210
Ashpole, Warrington, Mitschelen 2014; 307
Kiselev, Strecker, Ziyeh 2005; 53
Prewitt 1990
Lang, Lustig, Francois 1994; 120
Chiaravalloti, Fiorentini, Francesco 2016; 95
Wong, Backes, Drenthen 2020; 51
Girouard, Iadecola 2006; 100
Thore, Anstrom, Moody 2007; 66
Brown, Thore 2011; 37
Kalaria, Hedera 1995; 6
Freeze, Jacobs, de Jong 2020; 85
Kawakami, Mimura, Shoji 2014; 4
Arba, Mair, Carpenter 2017; 26
Challa, Thore, Moody 2004; 6
Baloyannis, Baloyannis 2012; 322
Wardlaw, Smith, Biessels 2013; 12
Bell, Winkler, Sagare 2010; 68
Wardlaw, Smith, Dichgans 2019; 18
Harper, Bohlen 1984; 6
Tucsek, Toth, Tarantini 2014; 69
Troprès, Pannetier, Grand 2015; 73
Sokolova, Manukhina, Blinkov 1985; 30
Paschoal, Leoni, Dos Santos 2018; 20
Yao, Sadoshima, Ibayashi 1992; 23
Perlmutter, Chui 1990; 24
Bell, Ball 1981; 53
Sonntag, Lynch, Cooney 1997; 138
Thrippleton 2019; 597
Purandare, Burns, Daly 2006; 332
Yannoutsos, Levy, Safar 2014; 32
Olenich, Audet, Roberts 2014; 592
Wilhelmus, Otte-Holler, van Triel 2007; 171
Ungvari, Tarantini, Kiss 2018; 15
Chen, Song, Beyea 2011; 7
Lin, Kisseleva, Brenner 2008; 173
Armulik, Genové, Mäe 2010; 468
Wong, Jansen, Zhang 2019; 92
Malaguarnera, Motta, Di Rosa 2006; 26
Toth, Csiszar, Tucsek 2013; 305
O'Sullivan, Lythgoe, Pereira 2002; 59
Vieni, Ades-Aron, Conti 2020; 204
Jespersen, Østergaard 2012; 32
Faraco, Iadecola 2013; 62
Dickie, Parker, Parkes 2020; 116
Moody, Thore, Anstrom 2004; 233
Promjunyakul, Lahna, Kaye 2015; 8
Yung, Chae, Buehler 2009; 106
Oomen, Farkas, Roman 2009; 1
Lopez-Lopez, LeRoith, Torres-Aleman 2004; 101
Bell, Ball 1986; 13
Hu, Lv, Li 2020; 99
Warrington, Csiszar, Johnson 2011; 300
Eskildsen, Gyldensted, Nagenthiraja 2017; 50
Dolui, Li, Nasrallah 2020; 25
van Osch, Teeuwisse, van Walderveen 2009; 62
Jahng, Li, Ostergaard 2014; 15
Ko, Cao, Liu 2010; 12
Meguro, Hatazawa, Yamaguchi 1990; 28
Haller, Zaharchuk, Thomas 2016; 281
Dong, Zeitlin, Song 2007; 313
Norling, Gerstenecker, Buford 2020; 42
Pavilla, Arrigo, Mejdoubi 2018; 42
Shi, Thrippleton, Makin 2016; 36
Kellner, Breyer, Gall 2015; 42
Gorelick, Scuteri, Black 2011; 42
Tarantini, Valcarcel-Ares, Toth 2019; 24
Wong, Zhang, van Bussel 2017; 14
Vogt, Schmid-Schonbein 2001; 8
Lichtenwalner, Forbes, Bennett 2001; 107
Li, Bentzen, Li 2008; 71
Grade, Hernandez Tamames, Pizzini 2015; 57
Patel, Quadros, Brem 2008; 15
Ballermann, Obeidat 2014; 4
Knutsson, Ståhlberg, Wirestam 2010; 23
Joutel, Monet-Lepretre, Gosele 2010; 120
Fischer, Siddiqi, Yusufaly 1990; 79
Nelis, Kleffner, Burg 2018; 8
van Bussel, Backes, Hofman 2015; 38
Mann, Eaves, Marcyniuk 1986; 7
Cheng, Diamond, Falkner 2008; 1
Tian, Bai, Yang 2013; 14
Sourbron, Buckley 2013; 26
Thiel, Gaisl, Lettau 2019; 61
Abernethy, Bell, Morris 1993; 121
Sung, Michael, Nagy 2010; 17
Fonseca, Ferreiro, Oliveira 2013; 1832
Li, Chen, Haimovitz-Friedman 2003; 63
Le Bihan, Breton, Lallemand 1986; 161
Alsop, Detre, Golay 2015; 73
Moore, Zhang, Maeda 2015; 18
Tarkowski, Issa, Sjögren 2002; 23
van Osch, Teeuwisse, Chen 2018; 38
Yamauchi, Fukuyama, Yamaguchi 1991; 48
Warrington, Csiszar, Mitschelen 2012; 7
Thrippleton, Backes, Sourbron 2019; 15
Bell, Ball 1990; 11
Brown, Thore, Moody 2005; 164
Roher, Lowenson, Clarke 1993; 90
Zhang, Gordon, Goldberg 2017; 72
Brown, Moody, Thore 2009; 283
Olfert 2016; 23
Tucsek, Toth, Sosnowska 2014; 69
Buee, Hof, Bouras 1994; 87
Bailey, Rivara, Rocher 2004; 26
Speck, Chang, DeSilva 2000; 12
Hauser, Schönknecht, Thomann 2013; 20
Morland, Andersson, Haugen 2017; 8
Miura, Saitoh, Kokubun 2017; 18
Bergamino, Nespodzany, Baxter 2020; 52
Tarantini, Valcarcel-Ares, Yabluchanskiy 2018; 17
Goligorsky 2010; 6
Schrimpf, Teebken, Wilhelmi 2014; 51
Kalaria, Kroon 1992; 84
van de Haar, Burgmans, Jansen 2016; 281
Ungvari, Kaley, de Cabo 2010; 65
Zhang, Gordon, Ma 2018
Armulik, Genové, Betsholtz 2011; 21
Tapp, Owen, Barman 2019; 74
Verheggen, de Jong, van Boxtel 2020; 42
Yamaguchi, Yamazaki, Lemere 1992; 141
bibr52-0271678X221076557
bibr78-0271678X221076557
bibr135-0271678X221076557
bibr1-0271678X221076557
bibr65-0271678X221076557
bibr122-0271678X221076557
bibr11-0271678X221076557
bibr80-0271678X221076557
bibr107-0271678X221076557
bibr51-0271678X221076557
bibr24-0271678X221076557
bibr108-0271678X221076557
bibr37-0271678X221076557
bibr64-0271678X221076557
bibr148-0271678X221076557
bibr77-0271678X221076557
bibr91-0271678X221076557
bibr23-0271678X221076557
bibr109-0271678X221076557
bibr49-0271678X221076557
bibr81-0271678X221076557
bibr119-0271678X221076557
Yamaguchi H (bibr73-0271678X221076557) 1992; 141
bibr79-0271678X221076557
bibr89-0271678X221076557
bibr124-0271678X221076557
bibr39-0271678X221076557
bibr3-0271678X221076557
bibr13-0271678X221076557
bibr63-0271678X221076557
bibr53-0271678X221076557
bibr134-0271678X221076557
bibr93-0271678X221076557
bibr123-0271678X221076557
bibr133-0271678X221076557
bibr48-0271678X221076557
bibr149-0271678X221076557
bibr38-0271678X221076557
bibr22-0271678X221076557
bibr2-0271678X221076557
bibr12-0271678X221076557
bibr75-0271678X221076557
bibr138-0271678X221076557
bibr62-0271678X221076557
bibr55-0271678X221076557
bibr4-0271678X221076557
bibr82-0271678X221076557
bibr90-0271678X221076557
bibr95-0271678X221076557
bibr9-0271678X221076557
bibr70-0271678X221076557
bibr67-0271678X221076557
Zhang N (bibr129-0271678X221076557) 2018
bibr104-0271678X221076557
bibr47-0271678X221076557
bibr27-0271678X221076557
bibr118-0271678X221076557
bibr87-0271678X221076557
bibr10-0271678X221076557
bibr131-0271678X221076557
bibr141-0271678X221076557
bibr20-0271678X221076557
Li YQ (bibr92-0271678X221076557) 2003; 63
bibr40-0271678X221076557
bibr30-0271678X221076557
bibr101-0271678X221076557
bibr111-0271678X221076557
bibr121-0271678X221076557
bibr50-0271678X221076557
bibr6-0271678X221076557
bibr60-0271678X221076557
bibr146-0271678X221076557
bibr25-0271678X221076557
bibr15-0271678X221076557
bibr35-0271678X221076557
bibr126-0271678X221076557
bibr136-0271678X221076557
bibr116-0271678X221076557
bibr45-0271678X221076557
bibr106-0271678X221076557
bibr102-0271678X221076557
bibr17-0271678X221076557
bibr98-0271678X221076557
Chen II (bibr7-0271678X221076557) 1981; 241
bibr128-0271678X221076557
bibr72-0271678X221076557
bibr85-0271678X221076557
bibr115-0271678X221076557
bibr44-0271678X221076557
bibr142-0271678X221076557
bibr31-0271678X221076557
Sung HK (bibr19-0271678X221076557) 2010; 17
bibr97-0271678X221076557
bibr84-0271678X221076557
bibr71-0271678X221076557
bibr57-0271678X221076557
bibr59-0271678X221076557
bibr69-0271678X221076557
Prewitt R. (bibr8-0271678X221076557) 1990
bibr29-0271678X221076557
bibr114-0271678X221076557
bibr33-0271678X221076557
bibr144-0271678X221076557
bibr43-0271678X221076557
bibr83-0271678X221076557
bibr143-0271678X221076557
bibr18-0271678X221076557
bibr28-0271678X221076557
bibr58-0271678X221076557
bibr139-0271678X221076557
bibr99-0271678X221076557
bibr32-0271678X221076557
bibr103-0271678X221076557
bibr42-0271678X221076557
bibr113-0271678X221076557
bibr125-0271678X221076557
bibr88-0271678X221076557
bibr105-0271678X221076557
bibr14-0271678X221076557
bibr112-0271678X221076557
bibr68-0271678X221076557
bibr54-0271678X221076557
bibr21-0271678X221076557
bibr34-0271678X221076557
bibr41-0271678X221076557
bibr61-0271678X221076557
bibr132-0271678X221076557
bibr74-0271678X221076557
bibr145-0271678X221076557
bibr94-0271678X221076557
bibr46-0271678X221076557
bibr16-0271678X221076557
bibr137-0271678X221076557
bibr66-0271678X221076557
bibr147-0271678X221076557
bibr76-0271678X221076557
bibr56-0271678X221076557
bibr127-0271678X221076557
bibr36-0271678X221076557
bibr26-0271678X221076557
bibr117-0271678X221076557
bibr110-0271678X221076557
bibr96-0271678X221076557
bibr86-0271678X221076557
bibr5-0271678X221076557
bibr140-0271678X221076557
bibr130-0271678X221076557
bibr120-0271678X221076557
bibr100-0271678X221076557
References_xml – volume: 300
  start-page: H736
  year: 2011
  end-page: 744
  article-title: Cerebral microvascular rarefaction induced by whole brain radiation is reversible by systemic hypoxia in mice
  publication-title: Am J Physiol Heart Circ Physiol
  contributor:
    fullname: Johnson
– volume: 17
  start-page: e12731
  year: 2018
  article-title: Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice
  publication-title: Aging Cell
  contributor:
    fullname: Yabluchanskiy
– volume: 173
  start-page: 1617
  year: 2008
  end-page: 1627
  article-title: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
  publication-title: Am J Pathol
  contributor:
    fullname: Brenner
– volume: 7
  start-page: e38692
  year: 2012
  article-title: Stereological analysis of neuron, glial and endothelial cell numbers in the human amygdaloid complex.
  publication-title: PLoS One
  contributor:
    fullname: Prensa
– volume: 1
  start-page: 75
  year: 2008
  end-page: 79
  article-title: Functional capillary rarefaction in mild blood pressure elevation
  publication-title: Clin Translational Sci
  contributor:
    fullname: Falkner
– volume: 12
  start-page: 381
  year: 2000
  end-page: 387
  article-title: Perfusion MRI of the human brain with dynamic susceptibility contrast: gradient-echo versus spin-echo techniques
  publication-title: J Magn Reson Imaging
  contributor:
    fullname: DeSilva
– volume: 62
  start-page: 165
  year: 2009
  end-page: 173
  article-title: Can arterial spin labeling detect white matter perfusion signal?
  publication-title: Magn Reson Med
  contributor:
    fullname: van Walderveen
– volume: 42
  start-page: 141
  year: 2020
  end-page: 158
  article-title: The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension
  publication-title: Geroscience
  contributor:
    fullname: Buford
– volume: 210
  start-page: 790
  year: 2014
  end-page: 798
  article-title: The neurovascular unit – concept review
  publication-title: Acta Physiol (Oxf)
  contributor:
    fullname: Sendeski
– volume: 99
  start-page: e20463
  year: 2020
  article-title: Effect of post-labeling delay on regional cerebral blood flow in arterial spin-labeling MR imaging
  publication-title: Medicine (Baltimore)
  contributor:
    fullname: Li
– volume: 18
  start-page: 1897
  year: 2017
  article-title: Mitochondrial-Targeted antioxidant maintains blood flow, mitochondrial function, and redox balance in old mice following prolonged limb ischemia
  publication-title: IJMS
  contributor:
    fullname: Kokubun
– volume: 73
  start-page: 325
  year: 2015
  end-page: 341
  article-title: Imaging the microvessel caliber and density: Principles and applications of microvascular MRI
  publication-title: Magn Reson Med
  contributor:
    fullname: Grand
– volume: 6
  start-page: 477
  year: 1995
  end-page: 480
  article-title: Differential degeneration of the cerebral microvasculature in Alzheimer's disease
  publication-title: Neuroreport
  contributor:
    fullname: Hedera
– volume: 23
  start-page: 146
  year: 2016
  end-page: 156
  article-title: Physiological capillary regression is not dependent on reducing VEGF expression
  publication-title: Microcirculation
  contributor:
    fullname: Olfert
– volume: 141
  start-page: 249
  year: 1992
  end-page: 259
  article-title: Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study
  publication-title: Am J Pathol
  contributor:
    fullname: Lemere
– volume: 52
  start-page: 1811
  year: 2020
  end-page: 1826
  article-title: Preliminary assessment of intravoxel incoherent motion Diffusion-Weighted MRI (IVIM-DWI) metrics in Alzheimer's disease
  publication-title: J Magn Reson Imaging
  contributor:
    fullname: Baxter
– volume: 8
  start-page: 8148
  year: 2018
  article-title: OCT-Angiography reveals reduced vessel density in the deep retinal plexus of CADASIL patients
  publication-title: Sci Rep
  contributor:
    fullname: Burg
– volume: 313
  start-page: 3645
  year: 2007
  end-page: 3657
  article-title: Level of endothelial cell apoptosis required for a significant decrease in microvessel density
  publication-title: Exp Cell Res
  contributor:
    fullname: Song
– volume: 116
  start-page: 19
  year: 2020
  end-page: 39
  article-title: Measuring water exchange across the blood-brain barrier using MRI
  publication-title: Prog Nucl Magn Reson Spectrosc
  contributor:
    fullname: Parkes
– volume: 9
  start-page: 2846
  year: 2019
  article-title: Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry
  publication-title: Sci Rep
  contributor:
    fullname: Leu
– start-page: 71
  year: 1990
  end-page: 79
  article-title: Structural and functional rarefaction of microvessels in hypertension
  publication-title: Blood Vessel Changes Hypertens: Struct Func
  contributor:
    fullname: Prewitt
– volume: 26
  start-page: 1506
  year: 2017
  end-page: 1513
  article-title: Cerebral white matter hypoperfusion increases with small-vessel disease burden. Data from the third international stroke trial
  publication-title: J Stroke Cerebrovasc Dis
  contributor:
    fullname: Carpenter
– volume: 4
  start-page: 107
  year: 2014
  end-page: 112
  article-title: Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes
  publication-title: Kidney Int Suppl (2011)
  contributor:
    fullname: Shoji
– volume: 24
  start-page: 677
  year: 1990
  end-page: 686
  article-title: Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review
  publication-title: Brain Res Bull
  contributor:
    fullname: Chui
– volume: 106
  start-page: 15279
  year: 2009
  end-page: 15284
  article-title: Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Buehler
– volume: 138
  start-page: 3515
  year: 1997
  end-page: 3520
  article-title: Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1
  publication-title: Endocrinology
  contributor:
    fullname: Cooney
– volume: 71
  start-page: 64
  year: 2008
  end-page: 70
  article-title: Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis
  publication-title: Int J Radiat Oncol Biol Phys
  contributor:
    fullname: Li
– volume: 38
  start-page: 876
  year: 2015
  end-page: 882
  article-title: On the interplay of microvasculature, parenchyma, and memory in type 2 diabetes
  publication-title: Diabetes Care
  contributor:
    fullname: Hofman
– volume: 90
  start-page: 10836
  year: 1993
  end-page: 10840
  article-title: beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Clarke
– volume: 34
  start-page: 5
  year: 2015
  end-page: 17
  article-title: Mechanisms of vessel pruning and regression
  publication-title: Dev Cell
  contributor:
    fullname: Augustin
– volume: 18
  start-page: 684
  year: 2019
  end-page: 696
  article-title: Small vessel disease: mechanisms and clinical implications
  publication-title: Lancet Neurol
  contributor:
    fullname: Dichgans
– volume: 257
  start-page: 62
  year: 2007
  end-page: 66
  article-title: Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well
  publication-title: J Neurol Sci
  contributor:
    fullname: Thore
– volume: 38
  start-page: 273
  year: 2016
  end-page: 289
  article-title: Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging
  publication-title: Age (Dordr)
  contributor:
    fullname: Valcarcel-Ares
– volume: 69
  start-page: 1212
  year: 2014
  end-page: 1226
  article-title: Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease
  publication-title: J Gerontol A Biol Sci Med Sci
  contributor:
    fullname: Sosnowska
– volume: 15
  start-page: 555
  year: 2018
  end-page: 565
  article-title: Endothelial dysfunction and angiogenesis impairment in the ageing vasculature
  publication-title: Nat Rev Cardiol
  contributor:
    fullname: Kiss
– volume: 42
  start-page: 1117
  year: 2015
  end-page: 1125
  article-title: MR evaluation of vessel size imaging of human gliomas: Validation by histopathology
  publication-title: J Magn Reson Imaging
  contributor:
    fullname: Gall
– volume: 24
  start-page: 101192
  year: 2019
  article-title: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
  publication-title: Redox Biol
  contributor:
    fullname: Toth
– volume: 14
  start-page: 216
  year: 2017
  end-page: 221
  article-title: Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging
  publication-title: Neuroimage Clin
  contributor:
    fullname: van Bussel
– volume: 95
  start-page: e4206
  year: 2016
  article-title: Is cerebral glucose metabolism related to blood-brain barrier dysfunction and intrathecal IgG synthesis in Alzheimer disease?: a 18F-FDG PET/CT study
  publication-title: Medicine (Baltimore)
  contributor:
    fullname: Francesco
– volume: 56
  start-page: 10
  year: 2021
  end-page: 19
  article-title: A comprehensive view on MRI techniques for imaging Blood-Brain barrier integrity
  publication-title: Invest Radiol
  contributor:
    fullname: Postma
– volume: 66
  start-page: 337
  year: 2007
  end-page: 345
  article-title: Morphometric analysis of arteriolar tortuosity in human cerebral white matter of preterm, young, and aged subjects
  publication-title: J Neuropathol Exp Neurol
  contributor:
    fullname: Moody
– volume: 7
  start-page: 185
  year: 2011
  end-page: 196
  article-title: Advances in perfusion magnetic resonance imaging in Alzheimer's disease
  publication-title: Alzheimers Dement
  contributor:
    fullname: Beyea
– volume: 57
  start-page: 1181
  year: 2015
  end-page: 1202
  article-title: A neuroradiologist's guide to arterial spin labeling MRI in clinical practice
  publication-title: Neuroradiology
  contributor:
    fullname: Pizzini
– volume: 20
  start-page: 705
  year: 2013
  end-page: 711
  article-title: Regional cerebral perfusion alterations in patients with mild cognitive impairment and Alzheimer disease using dynamic susceptibility contrast MRI
  publication-title: Acad Radiol
  contributor:
    fullname: Thomann
– volume: 17
  start-page: 206
  year: 2010
  end-page: 212
  article-title: Multifaceted role of vascular endothelial growth factor signaling in adult tissue physiology: an emerging concept with clinical implications
  publication-title: Curr Opin Hematol
  contributor:
    fullname: Nagy
– volume: 23
  start-page: 1
  year: 2010
  end-page: 21
  article-title: Absolute quantification of perfusion using dynamic susceptibility contrast MRI: pitfalls and possibilities
  publication-title: Magma
  contributor:
    fullname: Wirestam
– volume: 1832
  start-page: 2191
  year: 2013
  end-page: 2203
  article-title: Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells
  publication-title: Biochim Biophys Acta
  contributor:
    fullname: Oliveira
– volume: 35
  start-page: 512
  year: 2015
  end-page: 520
  article-title: Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease
  publication-title: J Cereb Blood Flow Metab
  contributor:
    fullname: Hamel
– volume: 27
  start-page: 171
  year: 1992
  end-page: 178
  article-title: The capillary network: a link between IVIM and classical perfusion
  publication-title: Magn Reson Med
  contributor:
    fullname: Turner
– volume: 204
  start-page: 116228
  year: 2020
  article-title: Effect of intravoxel incoherent motion on diffusion parameters in normal brain
  publication-title: Neuroimage
  contributor:
    fullname: Conti
– volume: 25
  start-page: 102146
  year: 2020
  article-title: Arterial spin labeling versus (18)F-FDG-PET to identify mild cognitive impairment
  publication-title: Neuroimage Clin
  contributor:
    fullname: Nasrallah
– volume: 33
  start-page: 1986
  year: 2002
  end-page: 1992
  article-title: Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease
  publication-title: Stroke
  contributor:
    fullname: Kraftsik
– volume: 62
  start-page: 810
  year: 2013
  end-page: 817
  article-title: Hypertension: a harbinger of stroke and dementia
  publication-title: Hypertension
  contributor:
    fullname: Iadecola
– volume: 307
  start-page: H858
  year: 2014
  end-page: 868
  article-title: Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells
  publication-title: Am J Physiol Heart Circ Physiol
  contributor:
    fullname: Mitschelen
– volume: 6
  start-page: 1
  year: 2010
  end-page: 10
  article-title: Microvascular rarefaction the decline and fall of blood vessels
  publication-title: Organogenesis
  contributor:
    fullname: Goligorsky
– volume: 12
  start-page: 723
  year: 2011
  end-page: 738
  article-title: Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
  publication-title: Nat Rev Neurosci
  contributor:
    fullname: Zlokovic
– volume: 100
  start-page: 328
  year: 2006
  end-page: 335
  article-title: Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
  publication-title: J Appl Physiol (1985)
  contributor:
    fullname: Iadecola
– volume: 69
  start-page: 1339
  year: 2014
  end-page: 1352
  article-title: Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice
  publication-title: J Gerontol A Biol Sci Med Sci
  contributor:
    fullname: Tarantini
– volume: 283
  start-page: 28
  year: 2009
  end-page: 31
  article-title: Microvascular changes in the white mater in dementia
  publication-title: J Neurol Sci
  contributor:
    fullname: Thore
– volume: 80
  start-page: 844
  year: 2013
  end-page: 866
  article-title: The pathobiology of vascular dementia
  publication-title: Neuron
  contributor:
    fullname: Iadecola
– volume: 37
  start-page: 56
  year: 2011
  end-page: 74
  article-title: Review: cerebral microvascular pathology in ageing and neurodegeneration
  publication-title: Neuropathol Appl Neurobiol
  contributor:
    fullname: Thore
– volume: 20
  start-page: 705
  year: 2018
  end-page: 714
  article-title: Intravoxel incoherent motion MRI in neurological and cerebrovascular diseases
  publication-title: Neuroimage Clin
  contributor:
    fullname: Dos Santos
– volume: 121
  start-page: 270
  year: 1993
  end-page: 274
  article-title: Microvascular density of the human paraventricular nucleus decreases with aging but not hypertension
  publication-title: Exp Neurol
  contributor:
    fullname: Morris
– volume: 164
  start-page: 662
  year: 2005
  end-page: 668
  article-title: Vascular damage after fractionated whole-brain irradiation in rats
  publication-title: Radiat Res
  contributor:
    fullname: Moody
– volume: 48
  start-page: 1067
  year: 1991
  end-page: 1071
  article-title: High-intensity area in the deep white matter indicating hemodynamic compromise in internal carotid artery occlusive disorders
  publication-title: Arch Neurol
  contributor:
    fullname: Yamaguchi
– volume: 8
  year: 2017
  article-title: Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
  publication-title: Nat Commun
  contributor:
    fullname: Haugen
– volume: 38
  start-page: 1461
  year: 2018
  end-page: 1480
  article-title: Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow
  publication-title: J Cereb Blood Flow Metab
  contributor:
    fullname: Chen
– volume: 6
  start-page: 408
  year: 1984
  end-page: 419
  article-title: Microvascular adaptation in the cerebral cortex of adult spontaneously hypertensive rats
  publication-title: Hypertension
  contributor:
    fullname: Bohlen
– volume: 322
  start-page: 117
  year: 2012
  end-page: 121
  article-title: The vascular factor in Alzheimer's disease: a study in Golgi technique and electron microscopy
  publication-title: J Neurol Sci
  contributor:
    fullname: Baloyannis
– volume: 4
  start-page: 45
  year: 2014
  end-page: 52
  article-title: Tipping the balance from angiogenesis to fibrosis in CKD
  publication-title: Kidney Int Suppl (2011)
  contributor:
    fullname: Obeidat
– volume: 79
  start-page: 672
  year: 1990
  end-page: 679
  article-title: Altered angioarchitecture in selected areas of brains with Alzheimer's disease
  publication-title: Acta Neuropathol
  contributor:
    fullname: Yusufaly
– volume: 32
  start-page: 216
  year: 2014
  end-page: 224
  article-title: Pathophysiology of hypertension: interactions between macro and microvascular alterations through endothelial dysfunction
  publication-title: J Hypertens
  contributor:
    fullname: Safar
– volume: 597
  start-page: 667
  year: 2019
  end-page: 668
  article-title: MRI measurement of blood-brain barrier leakage: minding the gaps
  publication-title: J Physiol
  contributor:
    fullname: Thrippleton
– volume: 8
  start-page: 224
  year: 2015
  end-page: 229
  article-title: Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures
  publication-title: Neuroimage Clin
  contributor:
    fullname: Kaye
– volume: 168
  start-page: 497
  year: 1988
  end-page: 505
  article-title: Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging
  publication-title: Radiology
  contributor:
    fullname: Lallemand
– volume: 120
  start-page: 3395
  year: 1994
  end-page: 3403
  article-title: Apoptosis during macrophage-dependent ocular tissue remodelling
  publication-title: Development
  contributor:
    fullname: Francois
– volume: 21
  start-page: 725
  year: 2010
  end-page: 739
  article-title: A review of string vessels or collapsed, empty basement membrane tubes
  publication-title: J Alzheimers Dis
  contributor:
    fullname: Brown
– volume: 68
  start-page: 877
  year: 2013
  end-page: 891
  article-title: Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells
  publication-title: J Gerontol A Biol Sci Med Sci
  contributor:
    fullname: Sosnowska
– volume: 42
  start-page: 85
  year: 2018
  end-page: 91
  article-title: Measuring cerebral hypoperfusion induced by hyperventilation challenge with intravoxel incoherent motion magnetic resonance imaging in healthy volunteers
  publication-title: J Comput Assist Tomogr
  contributor:
    fullname: Mejdoubi
– volume: 73
  start-page: 102
  year: 2015
  end-page: 116
  article-title: Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the european consortium for ASL in dementia
  publication-title: Magn Reson Med
  contributor:
    fullname: Golay
– volume: 15
  start-page: 5
  year: 2008
  end-page: 19
  article-title: Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide
  publication-title: Amyloid
  contributor:
    fullname: Brem
– volume: 15
  start-page: 840
  year: 2019
  end-page: 858
  article-title: Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations
  publication-title: Alzheimers Dement
  contributor:
    fullname: Sourbron
– volume: 5
  start-page: e986
  year: 2014
  article-title: STAT1-mediated bim expression promotes the apoptosis of retinal pericytes under high glucose conditions
  publication-title: Cell Death Dis
  contributor:
    fullname: Gurel
– volume: 28
  start-page: 378
  year: 1990
  end-page: 383
  article-title: Cerebral circulation and oxygen metabolism associated with subclinical periventricular hyperintensity as shown by magnetic resonance imaging
  publication-title: Ann Neurol
  contributor:
    fullname: Yamaguchi
– volume: 68
  start-page: 409
  year: 2010
  end-page: 427
  article-title: Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
  publication-title: Neuron
  contributor:
    fullname: Sagare
– volume: 61
  start-page: 1437
  year: 2019
  end-page: 1445
  article-title: Impact of hypertension on cerebral microvascular structure in CPAP-treated obstructive sleep apnoea patients: a diffusion magnetic resonance imaging study
  publication-title: Neuroradiology
  contributor:
    fullname: Lettau
– volume: 53
  start-page: 299
  year: 1981
  end-page: 318
  article-title: Morphometric comparison of hippocampal microvasculature in ageing and demented people: diameters and densities
  publication-title: Acta Neuropathol
  contributor:
    fullname: Ball
– volume: 50
  start-page: 107
  year: 2017
  end-page: 118
  article-title: Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study
  publication-title: Neurobiol Aging
  contributor:
    fullname: Nagenthiraja
– volume: 54
  start-page: 2409
  year: 2011
  end-page: 2416
  article-title: Retinal vascular tortuosity in persons with diabetes and diabetic retinopathy
  publication-title: Diabetologia
  contributor:
    fullname: Nguyen
– volume: 592
  start-page: 3325
  year: 2014
  end-page: 3338
  article-title: Effects of detraining on the temporal expression of positive and negative angioregulatory proteins in skeletal muscle of mice
  publication-title: J Physiol
  contributor:
    fullname: Roberts
– volume: 26
  start-page: 913
  year: 2013
  end-page: 931
  article-title: The 39 steps: evading error and deciphering the secrets for accurate dynamic susceptibility contrast MRI
  publication-title: NMR Biomed
  contributor:
    fullname: Calamante
– volume: 26
  start-page: 307
  year: 2006
  end-page: 312
  article-title: Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer's disease and vascular dementia
  publication-title: Neuropathology
  contributor:
    fullname: Di Rosa
– volume: 12
  start-page: 822
  year: 2013
  end-page: 838
  article-title: Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
  publication-title: Lancet Neurol
  contributor:
    fullname: Biessels
– volume: 32
  start-page: 264
  year: 2012
  end-page: 277
  article-title: The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism
  publication-title: J Cereb Blood Flow Metab
  contributor:
    fullname: Østergaard
– volume: 30
  start-page: 1
  year: 1985
  end-page: 9
  article-title: Rarefication of the arterioles and capillary network in the brain of rats with different forms of hypertension
  publication-title: Microvasc Res
  contributor:
    fullname: Blinkov
– volume: 25
  start-page: 283
  year: 2004
  end-page: 290
  article-title: Co-accumulation of vascular endothelial growth factor with beta-amyloid in the brain of patients with Alzheimer's disease
  publication-title: Neurobiol Aging
  contributor:
    fullname: Kang
– volume: 12
  start-page: 8
  year: 2003
  end-page: 16
  article-title: Pathologic evidence of microvascular rarefaction in the brain of renal hypertensive rats
  publication-title: J Stroke Cerebrovasc Dis
  contributor:
    fullname: Sakata
– volume: 233
  start-page: 883
  year: 2004
  end-page: 890
  article-title: Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosis
  publication-title: Radiology
  contributor:
    fullname: Anstrom
– volume: 74
  start-page: 1383
  year: 2019
  end-page: 1390
  article-title: Associations of retinal microvascular diameters and tortuosity with blood pressure and arterial stiffness: United Kingdom biobank
  publication-title: Hypertension
  contributor:
    fullname: Barman
– volume: 20
  start-page: 297
  year: 2011
  end-page: 305
  article-title: Mechanisms of fibrosis: the role of the pericyte
  publication-title: Curr Opin Nephrol Hypertens
  contributor:
    fullname: Duffield
– volume: 468
  start-page: 557
  year: 2010
  end-page: 561
  article-title: Pericytes regulate the blood-brain barrier
  publication-title: Nature
  contributor:
    fullname: Mäe
– volume: 51
  start-page: 247
  year: 2014
  end-page: 258
  article-title: The role of pericyte detachment in vascular rarefaction
  publication-title: J Vasc Res
  contributor:
    fullname: Wilhelmi
– volume: 26
  start-page: 573
  year: 2004
  end-page: 578
  article-title: The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
  publication-title: Neurol Res
  contributor:
    fullname: Rocher
– volume: 14
  start-page: 1412
  year: 2013
  end-page: 1427
  article-title: Shear stress inhibits apoptosis of ischemic brain microvascular endothelial cells
  publication-title: Int J Mol Sci
  contributor:
    fullname: Yang
– volume: 7
  start-page: 321
  year: 1986
  end-page: 330
  article-title: Quantitative changes in cerebral cortical microvasculature in ageing and dementia
  publication-title: Neurobiol Aging
  contributor:
    fullname: Marcyniuk
– volume: 13
  start-page: 456
  year: 1986
  end-page: 461
  article-title: The correlation of vascular capacity with the parenchymal lesions of Alzheimer's disease
  publication-title: Can J Neurol Sci
  contributor:
    fullname: Ball
– volume: 6
  start-page: 379
  year: 2004
  end-page: 383
  article-title: Increase of white matter string vessels in Alzheimer's disease.
  publication-title: J Alzheimers Dis
  contributor:
    fullname: Moody
– volume: 12
  start-page: 243
  year: 2010
  end-page: 251
  article-title: Hypertension management and microvascular insulin resistance in diabetes
  publication-title: Curr Hypertens Rep
  contributor:
    fullname: Liu
– volume: 42
  start-page: 1183
  year: 2020
  end-page: 1193
  article-title: Increase in blood-brain barrier leakage in healthy, older adults
  publication-title: Geroscience
  contributor:
    fullname: van Boxtel
– volume: 59
  start-page: 321
  year: 2002
  end-page: 326
  article-title: Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis
  publication-title: Neurology
  contributor:
    fullname: Pereira
– volume: 241
  start-page: H306
  year: 1981
  end-page: 310
  article-title: Microvascular rarefaction in spontaneously hypertensive rat cremaster muscle
  publication-title: Am J Physiol
  contributor:
    fullname: Dowell
– volume: 36
  start-page: 1653
  year: 2016
  end-page: 1667
  article-title: Cerebral blood flow in small vessel disease: a systematic review and Meta-analysis
  publication-title: J Cereb Blood Flow Metab
  contributor:
    fullname: Makin
– volume: 305
  start-page: H1698
  year: 2013
  end-page: 1708
  article-title: Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice
  publication-title: Am J Physiol Heart Circ Physiol
  contributor:
    fullname: Tucsek
– volume: 51
  start-page: 1170
  year: 2020
  end-page: 1180
  article-title: Spectral diffusion analysis of intravoxel incoherent motion MRI in cerebral small vessel disease
  publication-title: J Magn Reson Imaging
  contributor:
    fullname: Drenthen
– volume: 15
  start-page: 554
  year: 2014
  end-page: 577
  article-title: Perfusion magnetic resonance imaging: a comprehensive update on principles and techniques
  publication-title: Korean J Radiol
  contributor:
    fullname: Ostergaard
– volume: 42
  start-page: 2672
  year: 2011
  end-page: 2713
  article-title: Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association
  publication-title: Stroke
  contributor:
    fullname: Black
– volume: 281
  start-page: 337
  year: 2016
  end-page: 356
  article-title: Arterial spin labeling perfusion of the brain: Emerging clinical applications
  publication-title: Radiology
  contributor:
    fullname: Thomas
– volume: 12
  start-page: 643468
  year: 2021
  article-title: Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review
  publication-title: Front Physiol
  contributor:
    fullname: Marshall
– volume: 21
  start-page: 193
  year: 2011
  end-page: 215
  article-title: Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
  publication-title: Dev Cell
  contributor:
    fullname: Betsholtz
– volume: 72
  start-page: 168
  year: 2017
  end-page: 175
  article-title: Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease
  publication-title: Neurosci Biobehav Rev
  contributor:
    fullname: Goldberg
– volume: 332
  start-page: 1119
  year: 2006
  end-page: 1124
  article-title: Cerebral emboli as a potential cause of Alzheimer's disease and vascular dementia: case-control study
  publication-title: Bmj
  contributor:
    fullname: Daly
– volume: 65
  start-page: 1028
  year: 2010
  end-page: 1041
  article-title: Mechanisms of vascular aging: new perspectives
  publication-title: J Gerontol A Biol Sci Med Sci
  contributor:
    fullname: de Cabo
– volume: 92
  start-page: e1669
  year: 2019
  end-page: e1677
  article-title: Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease
  publication-title: Neurology
  contributor:
    fullname: Zhang
– volume: 85
  start-page: 113
  year: 2020
  end-page: 122
  article-title: White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed
  publication-title: Neurobiol Aging
  contributor:
    fullname: de Jong
– volume: 26
  start-page: 1004
  year: 2013
  end-page: 1027
  article-title: Classic models for dynamic contrast-enhanced MRI
  publication-title: NMR Biomed
  contributor:
    fullname: Buckley
– volume: 8
  start-page: 129
  year: 2001
  end-page: 139
  article-title: Microvascular endothelial cell death and rarefaction in the glucocorticoid-induced hypertensive rat
  publication-title: Microcirculation
  contributor:
    fullname: Schmid-Schonbein
– volume: 23
  start-page: 237
  year: 2002
  end-page: 243
  article-title: Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
  publication-title: Neurobiol Aging
  contributor:
    fullname: Sjögren
– volume: 53
  start-page: 553
  year: 2005
  end-page: 563
  article-title: Vessel size imaging in humans
  publication-title: Magn Reson Med
  contributor:
    fullname: Ziyeh
– volume: 171
  start-page: 1989
  year: 2007
  end-page: 1999
  article-title: Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
  publication-title: Am J Pathol
  contributor:
    fullname: van Triel
– volume: 11
  start-page: 359
  year: 1990
  end-page: 370
  article-title: Neuritic plaques and vessels of visual cortex in aging and Alzheimer's dementia
  publication-title: Neurobiol Aging
  contributor:
    fullname: Ball
– year: 2018
  article-title: The age-related perfusion pattern measured with arterial spin labeling MRI in healthy subjects
  publication-title: Front Aging Neurosci
  contributor:
    fullname: Ma
– volume: 120
  start-page: 433
  year: 2010
  end-page: 445
  article-title: Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
  publication-title: J Clin Invest
  contributor:
    fullname: Gosele
– volume: 23
  start-page: 1673
  year: 1992
  end-page: 1677
  article-title: Leukoaraiosis and dementia in hypertensive patients
  publication-title: Stroke
  contributor:
    fullname: Ibayashi
– volume: 281
  start-page: 527
  year: 2016
  end-page: 535
  article-title: Blood-Brain barrier leakage in patients with early Alzheimer disease
  publication-title: Radiology
  contributor:
    fullname: Jansen
– volume: 101
  start-page: 9833
  year: 2004
  end-page: 9838
  article-title: Insulin-like growth factor I is required for vessel remodeling in the adult brain
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Torres-Aleman
– volume: 63
  start-page: 5950
  year: 2003
  end-page: 5956
  article-title: Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation
  publication-title: Cancer Res
  contributor:
    fullname: Haimovitz-Friedman
– volume: 106
  start-page: 257
  year: 2021
  end-page: 267
  article-title: Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample
  publication-title: Neurobiology of Aging
  contributor:
    fullname: Verheggen
– volume: 87
  start-page: 469
  year: 1994
  end-page: 480
  article-title: Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders
  publication-title: Acta Neuropathol
  contributor:
    fullname: Bouras
– volume: 1
  start-page: 4
  year: 2009
  article-title: Resveratrol preserves cerebrovascular density and cognitive function in aging mice
  publication-title: Front Aging Neurosci
  contributor:
    fullname: Roman
– volume: 88
  start-page: 426
  year: 2017
  end-page: 432
  article-title: Blood-brain barrier leakage is more widespread in patients with cerebral small vessel disease
  publication-title: Neurology
  contributor:
    fullname: van de Haar
– volume: 107
  start-page: 603
  year: 2001
  end-page: 613
  article-title: Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
  publication-title: Neuroscience
  contributor:
    fullname: Bennett
– volume: 172
  start-page: 117
  year: 2009
  end-page: 120
  article-title: Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging
  publication-title: Psychiatry Res
  contributor:
    fullname: Muraskin
– year: 2020
  article-title: Changes in microvascular morphology in subcortical vascular dementia: a study of vessel size magnetic resonance imaging
  publication-title: Front Neurol
  contributor:
    fullname: Kim
– volume: 18
  start-page: 265
  year: 2015
  end-page: 281
  article-title: Cardiovascular risk factors cause premature rarefaction of the collateral circulation and greater ischemic tissue injury
  publication-title: Angiogenesis
  contributor:
    fullname: Maeda
– volume: 7
  start-page: e30444
  year: 2012
  article-title: Whole brain radiation-induced impairments in learning and memory are time-sensitive and reversible by systemic hypoxia
  publication-title: PLoS One
  contributor:
    fullname: Mitschelen
– volume: 84
  start-page: 606
  year: 1992
  end-page: 612
  article-title: Expression of leukocyte antigen CD34 by brain capillaries in Alzheimer's disease and neurologically normal subjects
  publication-title: Acta Neuropathol
  contributor:
    fullname: Kroon
– volume: 161
  start-page: 401
  year: 1986
  end-page: 407
  article-title: MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders
  publication-title: Radiology
  contributor:
    fullname: Lallemand
– ident: bibr87-0271678X221076557
  doi: 10.1016/0197-4580(86)90158-2
– ident: bibr113-0271678X221076557
  doi: 10.1113/JP277425
– volume: 63
  start-page: 5950
  year: 2003
  ident: bibr92-0271678X221076557
  publication-title: Cancer Res
  contributor:
    fullname: Li YQ
– ident: bibr53-0271678X221076557
  doi: 10.1097/nen.0b013e3180537147
– ident: bibr148-0271678X221076557
  doi: 10.3348/kjr.2014.15.5.554
– ident: bibr37-0271678X221076557
  doi: 10.1038/s41569-018-0030-z
– ident: bibr81-0271678X221076557
  doi: 10.1016/0197-4580(90)90001-G
– ident: bibr91-0271678X221076557
  doi: 10.1371/journal.pone.0030444
– ident: bibr32-0271678X221076557
  doi: 10.1097/HJH.0000000000000021
– ident: bibr22-0271678X221076557
  doi: 10.1113/jphysiol.2014.271213
– ident: bibr4-0271678X221076557
  doi: 10.1038/nrn3114
– ident: bibr12-0271678X221076557
  doi: 10.1038/ncomms15557
– ident: bibr100-0271678X221076557
  doi: 10.1002/mrm.25396
– volume: 141
  start-page: 249
  year: 1992
  ident: bibr73-0271678X221076557
  publication-title: Am J Pathol
  contributor:
    fullname: Yamaguchi H
– ident: bibr78-0271678X221076557
  doi: 10.1016/S0197-4580(03)00111-8
– ident: bibr147-0271678X221076557
  doi: 10.1038/s41598-018-26475-5
– ident: bibr90-0271678X221076557
  doi: 10.1667/RR3453.1
– ident: bibr109-0271678X221076557
  doi: 10.1002/jmri.24864
– ident: bibr103-0271678X221076557
  doi: 10.1016/j.jalz.2010.04.004
– ident: bibr24-0271678X221076557
  doi: 10.1016/S0197-4580(01)00285-8
– ident: bibr26-0271678X221076557
  doi: 10.1007/BF00294173
– ident: bibr116-0271678X221076557
  doi: 10.1148/radiol.2016152244
– ident: bibr141-0271678X221076557
  doi: 10.1016/j.nicl.2018.08.030
– ident: bibr49-0271678X221076557
  doi: 10.1016/j.devcel.2011.07.001
– ident: bibr108-0271678X221076557
  doi: 10.1038/s41598-018-37564-w
– ident: bibr127-0271678X221076557
  doi: 10.1016/j.pscychresns.2008.11.006
– ident: bibr144-0271678X221076557
  doi: 10.1002/jmri.26920
– ident: bibr82-0271678X221076557
  doi: 10.1007/BF00294246
– ident: bibr80-0271678X221076557
  doi: 10.1007/BF00690372
– ident: bibr85-0271678X221076557
  doi: 10.3233/JAD-2010-100219
– ident: bibr98-0271678X221076557
  doi: 10.1007/s10334-009-0190-2
– ident: bibr62-0271678X221076557
  doi: 10.1016/j.jns.2007.01.015
– ident: bibr65-0271678X221076557
  doi: 10.1152/ajpheart.00377.2013
– ident: bibr63-0271678X221076557
  doi: 10.1148/radiol.2333020981
– ident: bibr84-0271678X221076557
  doi: 10.1179/016164104225016272
– ident: bibr50-0271678X221076557
  doi: 10.1038/nature09522
– ident: bibr133-0271678X221076557
  doi: 10.1002/mrm.1910270116
– ident: bibr29-0271678X221076557
  doi: 10.1016/0361-9230(90)90007-M
– ident: bibr57-0271678X221076557
  doi: 10.1073/pnas.0905891106
– ident: bibr21-0271678X221076557
  doi: 10.1111/micc.12263
– ident: bibr120-0271678X221076557
  doi: 10.1002/mrm.25197
– ident: bibr46-0271678X221076557
  doi: 10.1038/cddis.2013.517
– ident: bibr44-0271678X221076557
  doi: 10.1097/MNH.0b013e328344c3d4
– ident: bibr15-0271678X221076557
  doi: 10.1073/pnas.0400337101
– ident: bibr117-0271678X221076557
  doi: 10.1007/s11357-020-00211-2
– ident: bibr43-0271678X221076557
  doi: 10.1038/jcbfm.2011.153
– ident: bibr6-0271678X221076557
  doi: 10.1111/j.1365-2990.2010.01139.x
– ident: bibr40-0271678X221076557
  doi: 10.3390/ijms18091897
– ident: bibr38-0271678X221076557
  doi: 10.1016/j.yexcr.2007.07.023
– ident: bibr99-0271678X221076557
  doi: 10.1002/nbm.2833
– ident: bibr86-0271678X221076557
  doi: 10.1006/exnr.1993.1095
– ident: bibr76-0271678X221076557
  doi: 10.1016/j.bbadis.2013.08.007
– ident: bibr13-0271678X221076557
  doi: 10.1210/endo.138.8.5330
– ident: bibr18-0271678X221076557
  doi: 10.1093/gerona/glu080
– ident: bibr23-0271678X221076557
  doi: 10.1038/jcbfm.2014.226
– ident: bibr89-0271678X221076557
  doi: 10.1152/ajpheart.01024.2010
– ident: bibr10-0271678X221076557
  doi: 10.1111/apha.12250
– ident: bibr60-0271678X221076557
  doi: 10.1016/j.neuron.2013.10.008
– ident: bibr146-0271678X221076557
  doi: 10.1097/MD.0000000000004206
– ident: bibr145-0271678X221076557
  doi: 10.1177/0271678X16662891
– ident: bibr104-0271678X221076557
  doi: 10.1016/j.acra.2013.01.020
– ident: bibr2-0271678X221076557
  doi: 10.1371/journal.pone.0038692
– ident: bibr14-0271678X221076557
  doi: 10.1016/S0306-4522(01)00378-5
– ident: bibr31-0271678X221076557
  doi: 10.1016/j.jns.2009.02.328
– ident: bibr39-0271678X221076557
  doi: 10.3389/neuro.24.004.2009
– ident: bibr59-0271678X221076557
  doi: 10.1038/kisup.2014.9
– ident: bibr42-0271678X221076557
  doi: 10.1111/acel.12731
– ident: bibr137-0271678X221076557
  doi: 10.2337/dc14-2043
– ident: bibr36-0271678X221076557
  doi: 10.3390/ijms14011412
– ident: bibr132-0271678X221076557
  doi: 10.1148/radiology.168.2.3393671
– ident: bibr30-0271678X221076557
  doi: 10.1007/BF00227737
– ident: bibr131-0271678X221076557
  doi: 10.1148/radiology.161.2.3763909
– ident: bibr114-0271678X221076557
  doi: 10.1212/WNL.0000000000003556
– ident: bibr75-0271678X221076557
  doi: 10.2353/ajpath.2007.070050
– ident: bibr77-0271678X221076557
  doi: 10.1080/13506120701814723
– ident: bibr83-0271678X221076557
  doi: 10.1161/01.STR.0000024523.82311.77
– start-page: 71
  year: 1990
  ident: bibr8-0271678X221076557
  publication-title: Blood Vessel Changes Hypertens: Struct Func
  contributor:
    fullname: Prewitt R.
– ident: bibr97-0271678X221076557
  doi: 10.1212/WNL.59.3.321
– ident: bibr123-0271678X221076557
  doi: 10.1016/j.pnmrs.2019.09.002
– ident: bibr101-0271678X221076557
  doi: 10.1002/1522-2586(200009)12:3<381::AID-JMRI2>3.0.CO;2-Y
– ident: bibr111-0271678X221076557
  doi: 10.1002/nbm.2940
– ident: bibr140-0271678X221076557
  doi: 10.1016/j.neuroimage.2019.116228
– ident: bibr51-0271678X221076557
  doi: 10.1016/j.neuron.2010.09.043
– year: 2018
  ident: bibr129-0271678X221076557
  publication-title: Front Aging Neurosci
  contributor:
    fullname: Zhang N
– ident: bibr125-0271678X221076557
  doi: 10.1016/j.neubiorev.2016.11.023
– ident: bibr112-0271678X221076557
  doi: 10.1016/j.jalz.2019.01.013
– ident: bibr55-0271678X221076557
  doi: 10.1007/s00125-011-2200-y
– ident: bibr48-0271678X221076557
  doi: 10.1038/kisup.2014.20
– ident: bibr79-0271678X221076557
  doi: 10.1017/S0317167100037124
– ident: bibr102-0271678X221076557
  doi: 10.1016/j.neurobiolaging.2016.11.004
– ident: bibr119-0271678X221076557
  doi: 10.1007/s00234-015-1571-z
– ident: bibr72-0271678X221076557
  doi: 10.1073/pnas.90.22.10836
– ident: bibr115-0271678X221076557
  doi: 10.1016/j.neurobiolaging.2019.09.017
– ident: bibr17-0271678X221076557
  doi: 10.1093/gerona/gls242
– ident: bibr67-0271678X221076557
  doi: 10.1007/s10456-015-9465-6
– ident: bibr34-0271678X221076557
  doi: 10.1080/713774024
– ident: bibr94-0271678X221076557
  doi: 10.1002/ana.410280313
– ident: bibr121-0271678X221076557
  doi: 10.1002/mrm.22002
– ident: bibr128-0271678X221076557
  doi: 10.1016/j.nicl.2015.04.012
– ident: bibr106-0271678X221076557
  doi: 10.1212/WNL.0000000000007263
– ident: bibr107-0271678X221076557
  doi: 10.1002/mrm.20383
– ident: bibr149-0271678X221076557
– ident: bibr66-0271678X221076557
  doi: 10.1093/gerona/glt177
– ident: bibr122-0271678X221076557
  doi: 10.1177/0271678X17713434
– ident: bibr68-0271678X221076557
  doi: 10.1053/jscd.2003.1
– ident: bibr124-0271678X221076557
  doi: 10.3389/fphys.2021.643468
– ident: bibr143-0271678X221076557
  doi: 10.1097/RLI.0000000000000723
– ident: bibr64-0271678X221076557
  doi: 10.1172/JCI39733
– ident: bibr33-0271678X221076557
  doi: 10.1111/j.1752-8062.2008.00016.x
– ident: bibr16-0271678X221076557
  doi: 10.1007/s11357-016-9931-0
– ident: bibr25-0271678X221076557
  doi: 10.1111/j.1440-1789.2006.00701.x
– ident: bibr35-0271678X221076557
  doi: 10.1007/s11906-010-0114-6
– ident: bibr52-0271678X221076557
  doi: 10.1016/j.jns.2012.07.010
– ident: bibr142-0271678X221076557
  doi: 10.1007/s00234-019-02292-z
– volume: 241
  start-page: H306
  year: 1981
  ident: bibr7-0271678X221076557
  publication-title: Am J Physiol
  contributor:
    fullname: Chen II
– ident: bibr41-0271678X221076557
  doi: 10.1016/j.redox.2019.101192
– ident: bibr105-0271678X221076557
  doi: 10.1016/j.jstrokecerebrovasdis.2017.03.002
– ident: bibr27-0271678X221076557
  doi: 10.3233/JAD-2004-6404
– ident: bibr1-0271678X221076557
  doi: 10.1152/japplphysiol.00966.2005
– ident: bibr95-0271678X221076557
  doi: 10.1001/archneur.1991.00530220089024
– ident: bibr126-0271678X221076557
  doi: 10.1016/j.nicl.2019.102146
– ident: bibr3-0271678X221076557
  doi: 10.1016/S1474-4422(19)30079-1
– ident: bibr74-0271678X221076557
  doi: 10.1161/HYPERTENSIONAHA.113.01063
– ident: bibr56-0271678X221076557
  doi: 10.1136/bmj.38814.696493.AE
– ident: bibr135-0271678X221076557
  doi: 10.1097/RCT.0000000000000640
– ident: bibr47-0271678X221076557
  doi: 10.1159/000365149
– volume: 17
  start-page: 206
  year: 2010
  ident: bibr19-0271678X221076557
  publication-title: Curr Opin Hematol
  contributor:
    fullname: Sung HK
– ident: bibr54-0271678X221076557
  doi: 10.1161/HYPERTENSIONAHA.119.13752
– ident: bibr139-0271678X221076557
  doi: 10.1016/j.neurobiolaging.2021.06.017
– ident: bibr110-0271678X221076557
  doi: 10.3389/fneur.2020.545450
– ident: bibr69-0271678X221076557
  doi: 10.1016/0026-2862(85)90032-9
– ident: bibr130-0271678X221076557
  doi: 10.1097/MD.0000000000020463
– ident: bibr134-0271678X221076557
  doi: 10.1016/j.nicl.2017.01.017
– ident: bibr28-0271678X221076557
  doi: 10.1097/00001756-199502000-00018
– ident: bibr61-0271678X221076557
  doi: 10.1016/S1474-4422(13)70124-8
– ident: bibr138-0271678X221076557
  doi: 10.1002/jmri.27272
– ident: bibr45-0271678X221076557
  doi: 10.2353/ajpath.2008.080433
– ident: bibr71-0271678X221076557
  doi: 10.1161/STR.0b013e3182299496
– ident: bibr93-0271678X221076557
  doi: 10.1152/ajpheart.00308.2014
– ident: bibr118-0271678X221076557
  doi: 10.1148/radiol.2016150789
– ident: bibr11-0271678X221076557
  doi: 10.1093/gerona/glq113
– ident: bibr70-0271678X221076557
  doi: 10.1161/01.HYP.6.3.408
– ident: bibr136-0271678X221076557
  doi: 10.1201/9780429427275-4
– ident: bibr88-0271678X221076557
  doi: 10.1016/j.ijrobp.2007.09.059
– ident: bibr96-0271678X221076557
  doi: 10.1161/01.STR.23.11.1673
– ident: bibr20-0271678X221076557
  doi: 10.1016/j.devcel.2015.06.004
– ident: bibr9-0271678X221076557
  doi: 10.1007/s11357-019-00139-2
– ident: bibr58-0271678X221076557
  doi: 10.1242/dev.120.12.3395
– ident: bibr5-0271678X221076557
  doi: 10.4161/org.6.1.10427
SSID ssj0008355
Score 2.501253
Snippet Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role...
Cerebral microvascular rarefaction, the reduction in number of functional or structural small blood vessels in the brain, is thought to play an important role...
SourceID pubmedcentral
proquest
crossref
pubmed
sage
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 718
SubjectTerms Blood-Brain Barrier - metabolism
Brain - blood supply
Brain - diagnostic imaging
Brain Diseases - pathology
Humans
Magnetic Resonance Imaging
Microvascular Rarefaction
Review
SummonAdditionalLinks – databaseName: Sage Journals GOLD Open Access 2024
  dbid: AFRWT
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fT9swED6x8rDxNGA_ysbkSYhJkzIS146dJ1ShVQiJPSAQfYsc22F9SIJo-8B_z50bV-tg0l4Tx7Z8zvnO9913AEeKaN64UIl1hUoEagPUg84n3GmTmqyyvqbk5Mtf-fmNuJjK6RZ0MRemX8H5D4JV4YyCsqa_m26jT_og4wn6Uhlq2SlHh0XlUqrT5aIpV9fdsaoGPaH49LKh0LYlQORjEtPbXsE2VzqXA9geT65ur9fKGw2SgHrEARIaoQ-Evjjo5lH2zD59DrP8AysWjq_JW9ihlAa2igPswpZv92B_3KK_3TyyYxZQoOF6fQ9en8UKcPvQjde0nayrWUPYvYhcZehk-z4rgs1aFmr9sYoKTjDXM3rOGaHq79h97J82BGvMXUuZkwwd_Y7oPjybNaFW0ju4mfy8PjtP-gINiRUjvUjQmuSpEUbWua8KrmubOTQxDC8Ez5w1hdPO2koVhXdKZhW6jlLUDp2m1NfS8NF7GLRd6z8Ck0bpSrrKicwIJ2rtJX5lufBK2FT7IXyPa13er3g4yixSlf8tmCF8jdIocckoBGJa3y3nJc-pfLkeiXQIH1bSWXc3kmmoOjIEtSG3dQNi4t58085-B0ZuikXnGsf9RhIu4yb-9wwP_rvlJ3jDKeMiYCw_w2DxsPSHaActqi_93n0CZr8F3g
  priority: 102
  providerName: SAGE Publications
Title Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging
URI https://journals.sagepub.com/doi/full/10.1177/0271678X221076557
https://www.ncbi.nlm.nih.gov/pubmed/35078344
https://search.proquest.com/docview/2622958340
https://pubmed.ncbi.nlm.nih.gov/PMC9014687
Volume 42
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9wwEB2S9NBeSj7axkkTVAgpFJy1tZJlH5clSyiklJLQvRl9OV2o5SW7OfTfZ6S1lm5CLrnKtiz0xtKM9eYNwJnwMm-UiVSbSqQMVwNcB41NqSllJnOlbeOTk69_FFe37PuUT7eAx1yYQNrXanbh_rYXbvYncCvnrR5Entjg5_XYH_0VpRhswzYaaAzR--UXXYrAW6QiT3ElnvZHmUFlCdt8E8U4RxSc-wp8Q56FWhOb-9IzZ_M5Z_I_4lfYiya78L53IsloNdg92LJuHw5GDgPo9h85J4HWGf6X78PbcSzpdgDdaK3DSbqGtJ6MF6moBKNm26c5kJkjoXgfUb6CBDG9ROeCeJr8HZnH_j3CpJV3zqdCEozcO6_fYcmsDcWPPsDt5PJmfJX2FRdSzYblMkX3kGaSSd4UVlW0bHRu0GeQtGI0N1pWpjRaK1FV1gieK4wFOWsMRkGZbbikw4-w4zpnD4FwKUrFjTIsl8ywprQcn9KUWcF0VtoEvsX5rucrYY06j9rjT3FK4EtEpMYp82ca0tnuYVHTwtcjRwCzBD6tEFp3F6FNQGxgt77BS2tvXkGLCxLbvYUl8NWjXPff9eLlER69-h3H8I76lIpAovwMO8v7B3uCjs5SncKb0eTX75vTYOCPncb-Iw
link.rule.ids 230,314,315,730,783,787,795,888,21978,27865,27934,27936,27937,44957,45345,53804,53806
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-N8TBeBmzAwqeREEhIaRPXjpPHqmIqsE48bKhvkb8yKohbre0D_PWc3biim3iAVztx4tz5fBf_7ncAb4SneaNMpNpUImVoDdAOGptSU8pM5krbxicnT86L8SX7NOXTPeAxFyaA9rWa9dyPtudm3wK2ctHqfsSJ9b9MRv7oryhF_w7cxfWasRikdwYYnYqAXKQiT9EWT7vDzMCzhG2-iWKkIwrOfQ2-Ac9CtYndnemWu3kbNfkH9CvsRqf34WucxwaE8r23Xqme_nWD4vGfJ_oADjv_lAw33Q9hz7ojOB46jM3bn-QtCYjR8Cv-CA5GsVrcMcyHW4pPMm9I63F-EeVKMCC3XQYFmTkS6gIS5YtTENOxfy6JR-BfkUUc3ysPaeWV81mW5Nr6kAEVlMzaUFfpEVyefrgYjdOumEOq2aBcpeh50kwyyZvCqoqWjc4NuiOSVozmRsvKlEZrJarKGsFzhWEmZ43BACuzDZd08Bj23dzZEyBcilJxowzLJTOsKS3HuzRlVjCdlTaB91GQ9WLD2VHnkdb8pgIk8DqKusZP5o9LpLPz9bKmhS91jpqRJfBkI_rtcFFnEhA7SrG9wLN27_agjAN7dyfTBN559ak7k7H8-xs-_e9nvIKD8cXkrD77eP75GdyjPnMjYDWfw_7qem1foD-1Ui_D6vkNfbUehA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxEB5BkYALhZbH0gJGQiAhbbLr2OvdY5QSlUerHqgUcVn5tSWCdaImOcCvZ-yso6YVl1693ueMxzPrz98H8E54mjfKRKpNJVKG0QDjoLEpNaXMZK60bfzm5JPT4vicfZnwyRWprwDa12rac7_bnpv-DNjKeav7ESfWPzsZ-aW_ohT9uWn6d-EejtmsiIV6F4QxsQjoRSryFOPxpFvQDFxL2OabKFY7ouDc6_ANeBYUJ7Znpxsp503k5BX4V5iRxrvwI77LGojyq7daqp7-e43m8VYv-xgedXkqGa67PIE71u3B_tBhjd7-Ie9JQI6GX_J78GAUVeP2YTbcUH2SWUNaj_eLaFeChbntdlKQqSNBH5AoL1JBTMcCuiAeiX9B5vH63olIKy-c321JLq0vHdBRybQN-kpP4Xz86fvoOO1EHVLNBuUyxQyUZpJJ3hRWVbRsdG4wLZG0YjQ3WlamNForUVXWCJ4rLDc5awwWWpltuKSDZ7DjZs6-AMKlKBU3yrBcMsOa0nI8S1NmBdNZaRP4GI1Zz9fcHXUe6c2vO0ECb6O5a_xkftlEOjtbLWpaeMlz9I4sgedr828uF_0mAbHlGJsOnr17-wjaObB4d3ZN4IN3oboLHYv_P-HLW9_jDdw_OxrX3z6ffj2Ah9Rv4AiQzUPYWV6u7CtMq5bqdRhA_wB4biEE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Assessment+of+microvascular+rarefaction+in+human+brain+disorders+using+physiological+magnetic+resonance+imaging&rft.jtitle=Journal+of+Cerebral+Blood+Flow+%26+Metabolism&rft.au=van+Dinther%2C+Maud&rft.au=Voorter%2C+Paulien+HM&rft.au=Jansen%2C+Jacobus+FA&rft.au=Jones%2C+Elizabeth+AV&rft.date=2022-05-01&rft.pub=SAGE+Publications&rft.issn=0271-678X&rft.eissn=1559-7016&rft.volume=42&rft.issue=5&rft.spage=718&rft.epage=737&rft_id=info:doi/10.1177%2F0271678X221076557&rft.externalDocID=10.1177_0271678X221076557
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0271-678X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0271-678X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0271-678X&client=summon