Direct distinction of ibuprofen and flurbiprofen enantiomers by ion mobility mass spectrometry of their ternary complexes with metal cations and cyclodextrins in the gas phase

• Published in: Journal of separation science Vol. 44; no. 12; pp. 2474 - 2482
• Main Authors: Gu, Liancheng, Wu, Fangling, Yang, Shutong, Xu, Fuxing, Dai, Xinhua, Jiang, You, Fang, Xiang, Yu, Shaoning, Ding, Chuan‐Fan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.06.2021
• Subjects: alkali metal ions; Calcium chloride; Coordination compounds; Cyclodextrins; Drugs; electrospray ionization mass spectrometry; Enantiomers; enantioselective analysis; enantioselectivity; Ibuprofen; ion mobility mass spectrometry; Ionic mobility; Ions; Mass spectrometry; Nonsteroidal anti-inflammatory drugs; pharmaceuticals; Scientific imaging; separation; Spectroscopy; Supramolecular compounds; Vapor phases; Enantioselective analysis; Cyclodextrins; Ion mobility mass spectrometry; Alkali metal ions; Pharmaceutical molecules

Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enant...