Direct distinction of ibuprofen and flurbiprofen enantiomers by ion mobility mass spectrometry of their ternary complexes with metal cations and cyclodextrins in the gas phase

Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enant...

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Published inJournal of separation science Vol. 44; no. 12; pp. 2474 - 2482
Main Authors Gu, Liancheng, Wu, Fangling, Yang, Shutong, Xu, Fuxing, Dai, Xinhua, Jiang, You, Fang, Xiang, Yu, Shaoning, Ding, Chuan‐Fan
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.06.2021
Subjects
alkali metal ions
Calcium chloride
Coordination compounds
Cyclodextrins
Drugs
electrospray ionization mass spectrometry
Enantiomers
enantioselective analysis
enantioselectivity
Ibuprofen
ion mobility mass spectrometry
Ionic mobility
Ions
Mass spectrometry
Nonsteroidal anti-inflammatory drugs
pharmaceuticals
Scientific imaging
separation
Spectroscopy
Supramolecular compounds
Vapor phases
Enantioselective analysis
Cyclodextrins
Ion mobility mass spectrometry
Alkali metal ions
Pharmaceutical molecules
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Abstract Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host–guest complex ions using trapped ion mobility time‐of‐flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl2, LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl2. The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method.
AbstractList Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host–guest complex ions using trapped ion mobility time‐of‐flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl2, LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl2. The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method.
Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host–guest complex ions using trapped ion mobility time‐of‐flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl₂, LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl₂. The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method.
Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host-guest complex ions using trapped ion mobility time-of-flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl2 , LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl2 . The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method.Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host-guest complex ions using trapped ion mobility time-of-flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl2 , LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl2 . The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method.
Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with MS technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host-guest complex ions using trapped ion mobility time-of-flight MS. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl , LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl . The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method. This article is protected by copyright. All rights reserved.
Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host–guest complex ions using trapped ion mobility time‐of‐flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl 2 , LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl 2 . The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method.
Author Dai, Xinhua
Yu, Shaoning
Yang, Shutong
Fang, Xiang
Xu, Fuxing
Wu, Fangling
Ding, Chuan‐Fan
Jiang, You
Gu, Liancheng
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  surname: Yang
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  organization: Fudan University
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  organization: National Institute of Metrology
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  fullname: Yu, Shaoning
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  organization: Ningbo University
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  givenname: Chuan‐Fan
  surname: Ding
  fullname: Ding, Chuan‐Fan
  email: dingchanfan@nbu.edu.cn
  organization: Ningbo University
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Issue 12
Keywords Enantioselective analysis
Cyclodextrins
Ion mobility mass spectrometry
Alkali metal ions
Pharmaceutical molecules
Language English
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Snippet Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a...
Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with MS technology provides a unique method...
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SubjectTerms alkali metal ions
Calcium chloride
Coordination compounds
Cyclodextrins
Drugs
electrospray ionization mass spectrometry
Enantiomers
enantioselective analysis
enantioselectivity
Ibuprofen
ion mobility mass spectrometry
Ionic mobility
Ions
Mass spectrometry
Nonsteroidal anti-inflammatory drugs
pharmaceuticals
Scientific imaging
separation
Spectroscopy
Supramolecular compounds
Vapor phases
Title Direct distinction of ibuprofen and flurbiprofen enantiomers by ion mobility mass spectrometry of their ternary complexes with metal cations and cyclodextrins in the gas phase
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjssc.202100025
https://www.ncbi.nlm.nih.gov/pubmed/33823081
https://www.proquest.com/docview/2543377040
https://www.proquest.com/docview/2509608059
https://www.proquest.com/docview/2636432618
Volume 44
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