Safety of repeated doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine in adults and adolescents
In light of waning immunity to pertussis following receipt of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine, maintaining protection may require repeated Tdap vaccination. We evaluated the safety of repeated doses of tetanus‐containing vaccine in 68 915 nonpregnant...
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| Published in | Pharmacoepidemiology and drug safety Vol. 27; no. 8; pp. 921 - 925 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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England
Wiley Subscription Services, Inc
01.08.2018
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| ISSN | 1053-8569 1099-1557 1099-1557 |
| DOI | 10.1002/pds.4569 |
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| Abstract | In light of waning immunity to pertussis following receipt of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine, maintaining protection may require repeated Tdap vaccination. We evaluated the safety of repeated doses of tetanus‐containing vaccine in 68 915 nonpregnant adolescents and adults in the Vaccine Safety Datalink population who had received an initial dose of Tdap. Compared with 7521 subjects who received a subsequent dose of tetanus toxoid, reduced diphtheria (Td) vaccine, the 61 394 subjects who received a subsequent dose of Tdap did not have significantly elevated risk of medical visits for seizure, cranial nerve disorders, limb swelling, pain in limb, cellulitis, paralytic syndromes, or encephalopathy/encephalitis/meningitis. These results suggest that repeated Tdap vaccination has acceptable safety relative to Tdap vaccination followed by Td vaccination. |
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| AbstractList | In light of waning immunity to pertussis following receipt of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine, maintaining protection may require repeated Tdap vaccination. We evaluated the safety of repeated doses of tetanus‐containing vaccine in 68 915 nonpregnant adolescents and adults in the Vaccine Safety Datalink population who had received an initial dose of Tdap. Compared with 7521 subjects who received a subsequent dose of tetanus toxoid, reduced diphtheria (Td) vaccine, the 61 394 subjects who received a subsequent dose of Tdap did not have significantly elevated risk of medical visits for seizure, cranial nerve disorders, limb swelling, pain in limb, cellulitis, paralytic syndromes, or encephalopathy/encephalitis/meningitis. These results suggest that repeated Tdap vaccination has acceptable safety relative to Tdap vaccination followed by Td vaccination. In light of waning immunity to pertussis following receipt of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine, maintaining protection may require repeated Tdap vaccination. We evaluated the safety of repeated doses of tetanus‐containing vaccine in 68 915 nonpregnant adolescents and adults in the Vaccine Safety Datalink population who had received an initial dose of Tdap. Compared with 7521 subjects who received a subsequent dose of tetanus toxoid, reduced diphtheria (Td) vaccine, the 61 394 subjects who received a subsequent dose of Tdap did not have significantly elevated risk of medical visits for seizure, cranial nerve disorders, limb swelling, pain in limb, cellulitis, paralytic syndromes, or encephalopathy/encephalitis/meningitis. These results suggest that repeated Tdap vaccination has acceptable safety relative to Tdap vaccination followed by Td vaccination. In light of waning immunity to pertussis following receipt of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine, maintaining protection may require repeated Tdap vaccination. We evaluated the safety of repeated doses of tetanus-containing vaccine in 68 915 nonpregnant adolescents and adults in the Vaccine Safety Datalink population who had received an initial dose of Tdap. Compared with 7521 subjects who received a subsequent dose of tetanus toxoid, reduced diphtheria (Td) vaccine, the 61 394 subjects who received a subsequent dose of Tdap did not have significantly elevated risk of medical visits for seizure, cranial nerve disorders, limb swelling, pain in limb, cellulitis, paralytic syndromes, or encephalopathy/encephalitis/meningitis. These results suggest that repeated Tdap vaccination has acceptable safety relative to Tdap vaccination followed by Td vaccination.In light of waning immunity to pertussis following receipt of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine, maintaining protection may require repeated Tdap vaccination. We evaluated the safety of repeated doses of tetanus-containing vaccine in 68 915 nonpregnant adolescents and adults in the Vaccine Safety Datalink population who had received an initial dose of Tdap. Compared with 7521 subjects who received a subsequent dose of tetanus toxoid, reduced diphtheria (Td) vaccine, the 61 394 subjects who received a subsequent dose of Tdap did not have significantly elevated risk of medical visits for seizure, cranial nerve disorders, limb swelling, pain in limb, cellulitis, paralytic syndromes, or encephalopathy/encephalitis/meningitis. These results suggest that repeated Tdap vaccination has acceptable safety relative to Tdap vaccination followed by Td vaccination. |
| Author | Jackson, Michael L. Jackson, Lisa A. Yu, Onchee McNeil, Michael M. Nelson, Jennifer C. Klein, Nicola P. Donahue, James G. Irving, Stephanie A. Tartof, Sara Y. Glanz, Jason M. Nordin, James D. |
| AuthorAffiliation | 1 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA 7 Kaiser Permanente Colorado, Denver, CO, USA 2 Health Partners Institute, Minneapolis, MN, USA 6 Kaiser Permanente Northwest, Portland, OR, USA 3 Kaiser Permanente Southern California, Pasadena, CA, USA 5 Marshfield Clinic Research Institute, Marshfield, WI, USA 4 Kaiser Permanente Northern California, Oakland, CA, USA 8 Centers for Disease Control and Prevention, Atlanta, GA, USA |
| AuthorAffiliation_xml | – name: 8 Centers for Disease Control and Prevention, Atlanta, GA, USA – name: 3 Kaiser Permanente Southern California, Pasadena, CA, USA – name: 7 Kaiser Permanente Colorado, Denver, CO, USA – name: 1 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA – name: 2 Health Partners Institute, Minneapolis, MN, USA – name: 6 Kaiser Permanente Northwest, Portland, OR, USA – name: 4 Kaiser Permanente Northern California, Oakland, CA, USA – name: 5 Marshfield Clinic Research Institute, Marshfield, WI, USA |
| Author_xml | – sequence: 1 givenname: Michael L. orcidid: 0000-0002-2340-0256 surname: Jackson fullname: Jackson, Michael L. email: jackson.ml@ghc.org organization: Kaiser Permanente Washington Health Research Institute – sequence: 2 givenname: Onchee orcidid: 0000-0002-7790-8135 surname: Yu fullname: Yu, Onchee organization: Kaiser Permanente Washington Health Research Institute – sequence: 3 givenname: Jennifer C. surname: Nelson fullname: Nelson, Jennifer C. organization: Kaiser Permanente Washington Health Research Institute – sequence: 4 givenname: James D. surname: Nordin fullname: Nordin, James D. organization: Health Partners Institute – sequence: 5 givenname: Sara Y. surname: Tartof fullname: Tartof, Sara Y. organization: Kaiser Permanente Southern California – sequence: 6 givenname: Nicola P. surname: Klein fullname: Klein, Nicola P. organization: Kaiser Permanente Northern California – sequence: 7 givenname: James G. surname: Donahue fullname: Donahue, James G. organization: Marshfield Clinic Research Institute – sequence: 8 givenname: Stephanie A. surname: Irving fullname: Irving, Stephanie A. organization: Kaiser Permanente Northwest – sequence: 9 givenname: Jason M. surname: Glanz fullname: Glanz, Jason M. organization: Kaiser Permanente Colorado – sequence: 10 givenname: Michael M. surname: McNeil fullname: McNeil, Michael M. organization: Centers for Disease Control and Prevention – sequence: 11 givenname: Lisa A. surname: Jackson fullname: Jackson, Lisa A. organization: Kaiser Permanente Washington Health Research Institute |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29862604$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.vaccine.2012.10.097 10.1016/j.vaccine.2011.07.068 10.1016/j.vaccine.2009.05.036 10.1086/655825 10.1001/jama.2015.12790 10.1542/peds.2015-3326 10.1016/j.vaccine.2011.11.035 10.1093/infdis/jiu322 10.1542/peds.2010-1722H 10.1016/j.vaccine.2010.10.025 10.1542/peds.2014-3358 |
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| References | 2011; 127 2015; 314 2015; 135 2010; 29 2006; 55 2011; 60 2013; 62 2013; 31 2016; 137 2014; 210 2011; 29 2009; 27 2010; 51 2012; 30 e_1_2_8_13_1 e_1_2_8_14_1 e_1_2_8_15_1 Broder KR (e_1_2_8_3_1) 2006; 55 Centers for Disease Control and Prevention (CDC) (e_1_2_8_4_1) 2013; 62 Centers for Disease Control and Prevention (CDC) (e_1_2_8_2_1) 2011; 60 e_1_2_8_5_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_10_1 e_1_2_8_11_1 e_1_2_8_12_1 |
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| SubjectTerms | Adolescent Adolescents Adult Brain Diseases - chemically induced Brain Diseases - epidemiology Cellulitis Cellulitis - chemically induced Cellulitis - epidemiology Child Cranial Nerve Diseases - chemically induced Cranial Nerve Diseases - epidemiology Diphtheria Diphtheria - prevention & control Diphtheria-Tetanus Vaccine - administration & dosage Diphtheria-Tetanus Vaccine - adverse effects Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage Diphtheria-Tetanus-acellular Pertussis Vaccines - adverse effects Encephalitis Encephalopathy Extremities Female Humans Immunization Schedule Longitudinal Studies Male Meningitis Middle Aged Musculoskeletal Pain - chemically induced Musculoskeletal Pain - epidemiology Pain Paralysis - chemically induced Paralysis - epidemiology Pertussis pharmacoepidemiology Safety Seizures Seizures - chemically induced Seizures - epidemiology Tetanus Tetanus - prevention & control United States - epidemiology Vaccination Vaccination - adverse effects Vaccination - methods Vaccines Whooping cough Whooping Cough - prevention & control Young Adult |
| Title | Safety of repeated doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine in adults and adolescents |
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