Stromal cell-derived factor-1 (SDF-1/CXCL12) gene polymorphisms in pulmonary tuberculosis patients of south India

• Published in: International journal of immunogenetics Vol. 39; no. 1; pp. 26 - 31
• Main Authors: Selvaraj, P., Alagarasu, K., Singh, B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2012
• Subjects: 3' Untranslated Regions; Adult; Case-Control Studies; Chemokine CXCL12 - genetics; Chemokine CXCL12 - immunology; CXCL12 protein; Female; Gene Frequency; Gene polymorphism; Genetic Predisposition to Disease - genetics; Haplotypes; Host-pathogen interactions; Humans; India - epidemiology; Introns; Linkage Disequilibrium; Lung; Male; Middle Aged; Mycobacterium; Mycobacterium tuberculosis - immunology; Mycobacterium tuberculosis - pathogenicity; Odds Ratio; Polymorphism, Single Nucleotide; SDF-1 protein; Sex; Sex Factors; Tuberculosis; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - genetics; Tuberculosis, Pulmonary - immunology; Tuberculosis, Pulmonary - microbiology; Young Adult; India

Summary CXCL12 gene polymorphisms influence CXCL12 levels and may be associated with the outcome of host–pathogen interaction. Hence, the present study was carried out to find out whether CXCL12 gene polymorphisms are associated with susceptibility or resistance to pulmonary tuberculosis (PTB). Intr...