Oestrogen receptors β1 and βcx have divergent roles in breast cancer survival and lymph node metastasis

• Published in: British journal of cancer Vol. 111; no. 5; pp. 918 - 926
• Main Authors: Rosin, G, de Boniface, J, Karthik, G M, Frisell, J, Bergh, J, Hartman, J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.08.2014; Nature Publishing Group
• Subjects: 692/53/2423; 692/699/67/1347; 692/699/67/322; 692/700/565/1331/238; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer Research; Drug Resistance; Epidemiology; Estrogen Receptor beta - metabolism; Female; Gynecology. Andrology. Obstetrics; Humans; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Mammary gland diseases; Medical sciences; Middle Aged; Molecular Diagnostics; Molecular Medicine; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Oncology; Prognosis; Tumors; Young Adult; breast cancer; pathology; oestrogen receptor; biomarkers; oncology; endocrine therapy; Estrogen receptor; Breast disease; Hormone therapy; Estrogen; Biological marker; Malignant lymphadenopathy; Malignant hemopathy; Breast cancer; Malignant tumor; Survival; Ovarian hormone; Lymph node metastasis; Mammary gland diseases; Anatomic pathology; Cancerology; Sex steroid hormone; Cancer; Hormonal receptor

Background: The expression of oestrogen receptor (ER) α characterises a subset of breast cancers associated with good response to endocrine therapy. However, the clinical significance of the second ER, ER β 1, and its splice variant ER β cx is still unclear. Methods: We here report an assessment of...